Gene Page: TNFSF13

Summary
GeneID  8741
Symbol  TNFSF13
Synonyms  APRIL|CD256|TALL2|TRDL-1|UNQ383/PRO715|ligand
Description  tumor necrosis factor (ligand) superfamily, member 13
See related  HGNC:11928|MIM:604472|Ensembl:ENSG00000161955|
Locus tag  -
Gene type  protein-coding
Map location  17p13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.943 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NCAPH20.850.86
INO80E0.830.81
AC010422.10.830.84
NTHL10.830.83
STK250.830.85
VPS280.820.85
RNF250.820.83
DDX410.820.83
MPND0.820.82
NOL120.810.83
Top 10 negatively co-expressed genes
AF347015.31-0.67-0.68
AF347015.33-0.67-0.69
MT-CYB-0.66-0.69
AF347015.2-0.66-0.69
MT-CO2-0.66-0.66
AF347015.8-0.66-0.69
AF347015.27-0.65-0.69
AF347015.26-0.65-0.71
AF347015.15-0.65-0.68
MT-ATP8-0.57-0.69
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005125cytokine activityIEA-
GO:0005164tumor necrosis factor receptor bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007165signal transductionTAS9743536 
GO:0008284positive regulation of cell proliferationTAS9743536 
GO:0006955immune responseIEA-
GO:0048298positive regulation of isotype switching to IgA isotypesIDA14988498 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIEA-
GO:0016020membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
FASALPS1A | APO-1 | APT1 | CD95 | FAS1 | FASTM | TNFRSF6Fas (TNF receptor superfamily, member 6)Reconstituted ComplexBioGRID10706119 
TNFRSF11BMGC29565 | OCIF | OPG | TR1tumor necrosis factor receptor superfamily, member 11bReconstituted ComplexBioGRID10706119 
TNFRSF13BCD267 | CVID | FLJ39942 | MGC133214 | MGC39952 | TACI | TNFRSF14Btumor necrosis factor receptor superfamily, member 13BAffinity Capture-Western
Reconstituted Complex		BioGRID10956646 
TNFRSF14ATAR | HVEA | HVEM | LIGHTR | TR2tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)Reconstituted ComplexBioGRID10706119 
TNFRSF17BCM | BCMA | CD269tumor necrosis factor receptor superfamily, member 17An unspecified isoform of APRIL interacts with BCMA. This interaction was modeled on a demonstrated interaction between human APRIL and BCMA from an unspecified species.BIND15846369 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1AReconstituted ComplexBioGRID10706119 
TNFSF13APRIL | CD256 | TALL2 | TRDL-1 | UNQ383/PRO715 | ligandtumor necrosis factor (ligand) superfamily, member 13Affinity Capture-WesternBioGRID12370363 
TNFSF13BBAFF | BLYS | CD257 | DTL | TALL-1 | TALL1 | THANK | TNFSF20 | ZTNF4tumor necrosis factor (ligand) superfamily, member 13bAffinity Capture-WesternBioGRID12370363 
XPO1CRM1 | DKFZp686B1823exportin 1 (CRM1 homolog, yeast)Affinity Capture-WesternBioGRID11565755 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION 4836All SZGR genes in this pathway
BIOCARTA_TALL1_PATHWAY 1515All SZGR genes in this pathway
REACTOME_METABOLISM_OF_MRNA 284128All SZGR genes in this pathway
REACTOME_METABOLISM_OF_RNA 330155All SZGR genes in this pathway
REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS 8450All SZGR genes in this pathway
CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_DN 391222All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_DN 187115All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
BARIS_THYROID_CANCER_DN 5945All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_TTD_UP 6439All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2 153102All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_3 2823All SZGR genes in this pathway
ROSS_AML_WITH_CBFB_MYH11_FUSION 5232All SZGR genes in this pathway
WANG_IMMORTALIZED_BY_HOXA9_AND_MEIS1_UP 3124All SZGR genes in this pathway
MEDINA_SMARCA4_TARGETS 4429All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K9ME3_UP 14175All SZGR genes in this pathway
RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_UP 10457All SZGR genes in this pathway
MIKKELSEN_MCV6_LCP_WITH_H3K4ME3 16280All SZGR genes in this pathway
MIKKELSEN_IPS_LCP_WITH_H3K4ME3 174100All SZGR genes in this pathway
MIKKELSEN_ES_LCP_WITH_H3K4ME3 14280All SZGR genes in this pathway
WANG_METASTASIS_OF_BREAST_CANCER_ESR1_DN 3018All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_DN 180116All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1991101161Ahsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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