Gene Page: IER3

Summary
GeneID  8870
Symbol  IER3
Synonyms  DIF-2|DIF2|GLY96|IEX-1|IEX-1L|IEX1|PRG1
Description  immediate early response 3
See related  HGNC:5392|MIM:602996|Ensembl:ENSG00000137331|HPRD:04295|
Locus tag  DAQB-47P19.3
Gene type  protein-coding
Map location  6p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.033 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
HIST1H2AM0.780.26
HIST1H2BF0.740.30
HIST1H3H0.740.28
SMCHD10.730.28
HIST1H2AD0.730.27
HIST1H3D0.700.34
HIST1H2AE0.690.31
HIST2H2AC0.690.19
HIST1H1E0.680.06
HIST1H2BG0.670.36
Top 10 negatively co-expressed genes
SLC9A3R2-0.20-0.14
PTPRK-0.19-0.15
TDRD10-0.19-0.17
CSGALNACT1-0.19-0.14
DOCK9-0.19-0.11
LGI4-0.18-0.12
KIF16B-0.18-0.15
LSR-0.18-0.14
ABCG2-0.18-0.11
KIAA1239-0.18-0.14
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003674molecular_functionND-
GO:0005515protein bindingIPI15451437 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0009653anatomical structure morphogenesisTAS9196025 
GO:0006916anti-apoptosisNAS9703517 
GO:0006916anti-apoptosisTAS9703517 
GO:0006915apoptosisTAS9196025 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005575cellular_componentND-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BAT3BAG-6 | BAG6 | D6S52E | G3HLA-B associated transcript 3An unspecified isoform of IEX-1 interacts with BAT3.BIND15451437 
CAMLGCAML | MGC163197calcium modulating ligandAn unspecified isoform of IEX-1 interacts with CAML.BIND15451437 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1Biochemical ActivityBioGRID12356731 
MAPK3ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3mitogen-activated protein kinase 3Affinity Capture-WesternBioGRID12356731 
MCL1BCL2L3 | EAT | MCL1L | MCL1S | MGC104264 | MGC1839 | TMmyeloid cell leukemia sequence 1 (BCL2-related)An unspecified isoform of IEX-1 interacts with MCL1.BIND15451437 
TNFSF10APO2L | Apo-2L | CD253 | TL2 | TRAILtumor necrosis factor (ligand) superfamily, member 10An unspecified isoform of IEX-1 interacts with TNFSF10.BIND15451437 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
FRASOR_TAMOXIFEN_RESPONSE_UP 5136All SZGR genes in this pathway
KOBAYASHI_EGFR_SIGNALING_6HR_DN 1813All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
PRAMOONJAGO_SOX4_TARGETS_UP 5238All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
RODRIGUES_NTN1_TARGETS_DN 158102All SZGR genes in this pathway
SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP 158103All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
BILBAN_B_CLL_LPL_DN 4225All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_UP 176123All SZGR genes in this pathway
NAGASHIMA_EGF_SIGNALING_UP 5840All SZGR genes in this pathway
KIM_WT1_TARGETS_UP 214155All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP 265158All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP 6446All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
GESERICK_TERT_TARGETS_DN 2116All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_FOREVER_DN 3123All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_324_UP 15093All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
KERLEY_RESPONSE_TO_CISPLATIN_UP 4430All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_UP 169127All SZGR genes in this pathway
TOMIDA_METASTASIS_UP 2613All SZGR genes in this pathway
MUELLER_METHYLATED_IN_GLIOBLASTOMA 4022All SZGR genes in this pathway
DUTTA_APOPTOSIS_VIA_NFKB 3325All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_1 4527All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
WEINMANN_ADAPTATION_TO_HYPOXIA_DN 4133All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_UP 227137All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2 153102All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
TONG_INTERACT_WITH_PTTG1 5732All SZGR genes in this pathway
AMIT_EGF_RESPONSE_40_HELA 4229All SZGR genes in this pathway
AMIT_EGF_RESPONSE_60_MCF10A 3924All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
FRASOR_RESPONSE_TO_ESTRADIOL_DN 8252All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
MANALO_HYPOXIA_UP 207145All SZGR genes in this pathway
OSAWA_TNF_TARGETS 106All SZGR genes in this pathway
ADDYA_ERYTHROID_DIFFERENTIATION_BY_HEMIN 7347All SZGR genes in this pathway
GALINDO_IMMUNE_RESPONSE_TO_ENTEROTOXIN 8567All SZGR genes in this pathway
NEMETH_INFLAMMATORY_RESPONSE_LPS_UP 8864All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_DN 12890All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP 7752All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_UP 183111All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN 162102All SZGR genes in this pathway
BASSO_CD40_SIGNALING_UP 10176All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_RESPONSE 3528All SZGR genes in this pathway
INGA_TP53_TARGETS 1713All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_UP 180125All SZGR genes in this pathway
GERHOLD_ADIPOGENESIS_DN 6444All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_UP 244151All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_DN 245144All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_2HR 5136All SZGR genes in this pathway
BURTON_ADIPOGENESIS_1 3324All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_48HR_DN 161105All SZGR genes in this pathway
SAFFORD_T_LYMPHOCYTE_ANERGY 8754All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C3 2015All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G2 3018All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_UP 253147All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE 261166All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
STEIN_ESRRA_TARGETS_RESPONSIVE_TO_ESTROGEN_UP 3120All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP 282183All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
MARZEC_IL2_SIGNALING_UP 11580All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN 274165All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_UP 250168All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_UP 12568All SZGR genes in this pathway
JIANG_TIP30_TARGETS_UP 4628All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_DN 175103All SZGR genes in this pathway
HELLEBREKERS_SILENCED_DURING_TUMOR_ANGIOGENESIS 8056All SZGR genes in this pathway
SEKI_INFLAMMATORY_RESPONSE_LPS_UP 7756All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
PARK_TRETINOIN_RESPONSE_AND_PML_RARA_FUSION 3021All SZGR genes in this pathway
PARK_TRETINOIN_RESPONSE_AND_RARA_PLZF_FUSION 2214All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
HINATA_NFKB_TARGETS_FIBROBLAST_UP 8460All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_DN 7247All SZGR genes in this pathway
HOFMANN_MYELODYSPLASTIC_SYNDROM_LOW_RISK_DN 3020All SZGR genes in this pathway
HOFMANN_MYELODYSPLASTIC_SYNDROM_RISK_UP 2414All SZGR genes in this pathway
LEE_SP4_THYMOCYTE 1411All SZGR genes in this pathway
CROONQUIST_STROMAL_STIMULATION_UP 6042All SZGR genes in this pathway
CROONQUIST_NRAS_VS_STROMAL_STIMULATION_DN 9965All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G56_DN 179All SZGR genes in this pathway
COULOUARN_TEMPORAL_TGFB1_SIGNATURE_UP 10968All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SURVIVAL_UP 7349All SZGR genes in this pathway
STEIN_ESRRA_TARGETS 535325All SZGR genes in this pathway
KOBAYASHI_EGFR_SIGNALING_24HR_DN 251151All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S1 237159All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_12HR_DN 3325All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_24HR_DN 4332All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_32HR_DN 3928All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_48HR_DN 4029All SZGR genes in this pathway
TIAN_TNF_SIGNALING_NOT_VIA_NFKB 2216All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_5 3022All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G28 2011All SZGR genes in this pathway
DASU_IL6_SIGNALING_UP 5944All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_UP 307182All SZGR genes in this pathway
QI_HYPOXIA 14096All SZGR genes in this pathway
LU_EZH2_TARGETS_UP 295155All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_UP 281183All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
VANDESLUIS_COMMD1_TARGETS_GROUP_3_UP 8950All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_UP 344215All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_1HR_UP 3426All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_UP 199143All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
PHONG_TNF_TARGETS_UP 6343All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_PARTIAL 160106All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_2HR_UP 5333All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_6HR_UP 16697All SZGR genes in this pathway
ZWANG_CLASS_3_TRANSIENTLY_INDUCED_BY_EGF 222159All SZGR genes in this pathway


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