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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: SLC9A3R1

Summary

GeneID

9368

Symbol

SLC9A3R1

Synonyms

EBP50|NHERF|NHERF1|NPHLOP2

Description

solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1

Locus tag

Gene type

protein-coding

Map location

17q25.1

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0231

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

GYG2

0.69

0.65

AC063977.1

0.66

0.72

DNER

0.63

0.71

C15orf39

0.63

0.62

ORAI2

0.63

0.76

RADIL

0.63

MAP2K3

0.60

0.66

LRRN2

0.60

0.72

DCLK2

0.60

0.62

CHST2

0.60

0.70

Top 10 negatively co-expressed genes

AF347015.31

-0.35

-0.43

AF347015.21

-0.35

-0.45

MT-CO2

-0.34

-0.42

AF347015.8

-0.34

-0.41

AF347015.2

-0.34

-0.41

AF347015.27

-0.33

-0.39

AF347015.33

-0.33

-0.38

MT-CYB

-0.32

-0.39

AF347015.15

-0.31

-0.37

MT-ATP8

-0.31

-0.41

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005515

protein binding

IPI

11285285 |12471024

GO:0030165

PDZ domain binding

IPI

16236806

GO:0031698

beta-2 adrenergic receptor binding

IPI

9560162

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006461

protein complex assembly

TAS

9430655

GO:0016055

Wnt receptor signaling pathway

IEA

GO:0030643

cellular phosphate ion homeostasis

IEA

GO:0032415

regulation of sodium:hydrogen antiporter activity

NAS

9560162

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0042995

cell projection

IEA

axon (GO term level: 4)

GO:0012505

endomembrane system

IEA

GO:0016020

membrane

IEA

GO:0015629

actin cytoskeleton

TAS

9430655

GO:0016324

apical plasma membrane

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABCC2	ABC30 \| CMOAT \| DJS \| KIAA1010 \| MRP2 \| cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	-	HPRD,BioGRID	12615054
ADRB2	ADRB2R \| ADRBR \| B2AR \| BAR \| BETA2AR	adrenergic, beta-2-, receptor, surface	-	HPRD,BioGRID	9560162 \|9671706
ADRB2	ADRB2R \| ADRBR \| B2AR \| BAR \| BETA2AR	adrenergic, beta-2-, receptor, surface	PDZ domain of NHERF binds to the C-terminus of B2AR.	BIND	9560162 \|9671706 \|12621035
AKAP10	D-AKAP2 \| MGC9414 \| PRKA10	A kinase (PRKA) anchor protein 10	-	HPRD	14531806
ATP6V1E1	ATP6E \| ATP6E2 \| ATP6V1E \| P31 \| Vma4	ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1	-	HPRD	10748165
CFTR	ABC35 \| ABCC7 \| CF \| CFTR/MRP \| MRP7 \| TNR-CFTR \| dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	First PDZ domain of EBP50 binds to the C-terminus of CFTR.	BIND	9671706 \|9677412 \|10852925 \|12621035
			-	HPRD	9613608 \|9677412 \|10852925
			Affinity Capture-Western in vitro in vivo Reconstituted Complex	BioGRID	9613608 \|9671706 \|9677412 \|10852925 \|12471024 \|12615054
CLCN3	CLC3 \| ClC-3	chloride channel 3	-	HPRD,BioGRID	12471024
CNGA2	CNCA \| CNCA1 \| CNG2 \| FLJ46312 \| OCNC1 \| OCNCALPHA \| OCNCa	cyclic nucleotide gated channel alpha 2	-	HPRD	14604981
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	-	HPRD,BioGRID	12830000
EZR	CVIL \| CVL \| DKFZp762H157 \| FLJ26216 \| MGC1584 \| VIL2	ezrin	-	HPRD,BioGRID	9314537
GNAQ	G-ALPHA-q \| GAQ	guanine nucleotide binding protein (G protein), q polypeptide	-	HPRD,BioGRID	12193606
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	Affinity Capture-Western	BioGRID	11956211
KCNJ1	KIR1.1 \| ROMK \| ROMK1	potassium inwardly-rectifying channel, subfamily J, member 1	-	HPRD,BioGRID	14604981
KCNJ1	KIR1.1 \| ROMK \| ROMK1		An unspecified isoform of ROMK interacts with NHERF-1. This interaction was modeled on a demonstrated interaction between Rat ROMK2 and Human NHERF-1.	BIND	14604981
LHCGR	FLJ41504 \| LCGR \| LGR2 \| LH/CG-R \| LH/CGR \| LHR \| LHRHR \| LSH-R	luteinizing hormone/choriogonadotropin receptor	hLHR interacts with EBP50.	BIND	14507927
MSN	-	moesin	moesin interacts with hNHE-RF.	BIND	9430655
MSN	-	moesin	-	HPRD,BioGRID	9430655
NF2	ACN \| BANF \| SCH	neurofibromin 2 (merlin)	-	HPRD,BioGRID	9430655
NF2	ACN \| BANF \| SCH	neurofibromin 2 (merlin)	Merlin interacts with hNHE-RF	BIND	9430655
NOS2	HEP-NOS \| INOS \| NOS \| NOS2A	nitric oxide synthase 2, inducible	-	HPRD,BioGRID	12080081
OPRK1	KOR \| OPRK	opioid receptor, kappa 1	-	HPRD,BioGRID	12004055
OPRK1	KOR \| OPRK	opioid receptor, kappa 1	-	HPRD	15070904
P2RY1	P2Y1	purinergic receptor P2Y, G-protein coupled, 1	NHERF interacts with P2Y1R.	BIND	9671706
P2RY1	P2Y1	purinergic receptor P2Y, G-protein coupled, 1	-	HPRD,BioGRID	9671706
PAG1	CBP \| FLJ37858 \| MGC138364 \| PAG	phosphoprotein associated with glycosphingolipid microdomains 1	-	HPRD,BioGRID	11684085
PDGFRA	CD140A \| MGC74795 \| PDGFR2 \| Rhe-PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	-	HPRD,BioGRID	11046132 \|11882663
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	-	HPRD,BioGRID	11046132
PDZK1	CAP70 \| CLAMP \| NHERF3 \| PDZD1	PDZ domain containing 1	Reconstituted Complex Two-hybrid	BioGRID	14531806
PIK3CA	MGC142161 \| MGC142163 \| PI3K \| p110-alpha	phosphoinositide-3-kinase, catalytic, alpha polypeptide	Reconstituted Complex	BioGRID	12954600
PLCB1	FLJ45792 \| PI-PLC \| PLC-154 \| PLC-I \| PLC154	phospholipase C, beta 1 (phosphoinositide-specific)	-	HPRD,BioGRID	10980202
PLCB2	FLJ38135	phospholipase C, beta 2	-	HPRD	10980202
PTH1R	MGC138426 \| MGC138452 \| PTHR \| PTHR1	parathyroid hormone 1 receptor	-	HPRD,BioGRID	12075354
RDX	DFNB24	radixin	Radixin interacts with hNHE-RF. This interaction was modeled on a demonstrated interaction between chicken radixin and human hNHE-RF.	BIND	9430655
RDX	DFNB24	radixin	-	HPRD	9430655\|12499563
SLC4A8	DKFZp761B2318 \| FLJ46462 \| NBC3	solute carrier family 4, sodium bicarbonate cotransporter, member 8	-	HPRD,BioGRID	12444018
SLC9A3	MGC126718 \| MGC126720 \| NHE3	solute carrier family 9 (sodium/hydrogen exchanger), member 3	-	HPRD,BioGRID	14580213
SLC9A3R1	EBP50 \| NHERF \| NHERF1 \| NPHLOP2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	Far Western Reconstituted Complex	BioGRID	11046132 \|15070904
TBC1D10A	EPI64 \| TBC1D10 \| dJ130H16.1 \| dJ130H16.2	TBC1 domain family, member 10A	-	HPRD,BioGRID	11285285
TRPC5	TRP5	transient receptor potential cation channel, subfamily C, member 5	-	HPRD	10980202
YAP1	YAP \| YAP2 \| YAP65 \| YKI	Yes-associated protein 1, 65kDa	-	HPRD,BioGRID	10562288
YES1	HsT441 \| P61-YES \| Yes \| c-yes	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	Reconstituted Complex	BioGRID	10562288

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
BIOCARTA_CFTR_PATHWAY	12	11	All SZGR genes in this pathway
WNT_SIGNALING	89	71	All SZGR genes in this pathway
PID_TXA2PATHWAY	57	43	All SZGR genes in this pathway
PID_PDGFRB_PATHWAY	129	103	All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN	526	357	All SZGR genes in this pathway
ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_UP	183	119	All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_UP	380	215	All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP	450	256	All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_DN	126	86	All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_DN	77	46	All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_DN	162	116	All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP	1821	933	All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN	378	231	All SZGR genes in this pathway
WANG_ESOPHAGUS_CANCER_VS_NORMAL_DN	101	66	All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_DN	62	44	All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL	330	217	All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL	330	215	All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_UP	134	93	All SZGR genes in this pathway
PATIL_LIVER_CANCER	747	453	All SZGR genes in this pathway
LIEN_BREAST_CARCINOMA_METAPLASTIC_VS_DUCTAL_DN	114	58	All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_UP	209	139	All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_DN	103	71	All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN	848	527	All SZGR genes in this pathway
LOPEZ_MBD_TARGETS	957	597	All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN	206	136	All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON	335	181	All SZGR genes in this pathway
UEDA_PERIFERAL_CLOCK	169	111	All SZGR genes in this pathway
STOSSI_RESPONSE_TO_ESTRADIOL	50	35	All SZGR genes in this pathway
LEI_MYB_TARGETS	318	215	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_UP	225	139	All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN	287	208	All SZGR genes in this pathway
TSENG_IRS1_TARGETS_UP	113	71	All SZGR genes in this pathway
BILD_E2F3_ONCOGENIC_SIGNATURE	246	153	All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_UP	66	44	All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_UP	172	109	All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN	701	446	All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN	546	362	All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN	342	220	All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_DN	210	128	All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_ESR1_UP	167	99	All SZGR genes in this pathway
LEE_DIFFERENTIATING_T_LYMPHOCYTE	200	115	All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3	1069	729	All SZGR genes in this pathway
COULOUARN_TEMPORAL_TGFB1_SIGNATURE_DN	138	99	All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION	368	247	All SZGR genes in this pathway
MARSON_FOXP3_TARGETS_UP	66	43	All SZGR genes in this pathway
KARLSSON_TGFB1_TARGETS_DN	207	139	All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN	374	217	All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_6HR_UP	229	149	All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP	324	193	All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN	1972	1213	All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_UP	211	131	All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_UP	281	183	All SZGR genes in this pathway
VANDESLUIS_COMMD1_TARGETS_GROUP_3_UP	89	50	All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP	682	433	All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_DN	428	246	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-339	404	410	m8	hsa-miR-339	UCCCUGUCCUCCAGGAGCUCA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.