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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: ZEB2

Summary

GeneID

9839

Symbol

ZEB2

Synonyms

KIAA0569|SIP-1|SIP1|SMADIP1|ZFHX1B

Description

zinc finger E-box binding homeobox 2

Locus tag

Gene type

protein-coding

Map location

2q22

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.023

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.02395

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 2

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003676

nucleic acid binding

IEA

GO:0003700

transcription factor activity

IEA

GO:0008270

zinc ion binding

IEA

GO:0019208

phosphatase regulator activity

NAS

11477103

GO:0046872

metal ion binding

IEA

GO:0043565

sequence-specific DNA binding

IEA

GO:0046332

SMAD binding

NAS

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007417

central nervous system development

IEA

Brain (GO term level: 6)

GO:0007399

nervous system development

NAS

neurite (GO term level: 5)

11279515

GO:0001756

somitogenesis

IEA

GO:0001755

neural crest cell migration

IEA

GO:0001843

neural tube closure

IEA

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0016481

negative regulation of transcription

11592033

GO:0048598

embryonic morphogenesis

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005622

intracellular

IEA

GO:0005634

nucleus

9853615

Interactions

Shown by Network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
COPS6	CSN6 \| MOV34-34KD	COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)	Two-hybrid	BioGRID	16169070
SMAD1	BSP1 \| JV4-1 \| JV41 \| MADH1 \| MADR1	SMAD family member 1	-	HPRD	10400677
SMAD2	JV18 \| JV18-1 \| MADH2 \| MADR2 \| MGC22139 \| MGC34440 \| hMAD-2 \| hSMAD2	SMAD family member 2	-	HPRD	10400677
SMAD3	DKFZp586N0721 \| DKFZp686J10186 \| HSPC193 \| HsT17436 \| JV15-2 \| MADH3 \| MGC60396	SMAD family member 3	-	HPRD	10400677
SMAD5	DKFZp781C1895 \| DKFZp781O1323 \| Dwfc \| JV5-1 \| MADH5	SMAD family member 5	-	HPRD	10400677

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
ONKEN_UVEAL_MELANOMA_UP	783	507	All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP	351	230	All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN	463	290	All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP	485	293	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP	1382	904	All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_UP	306	188	All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN	11	5	All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_UP	146	99	All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP	544	308	All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN	805	505	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP	552	347	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN	770	415	All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_5_6WK_DN	137	97	All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_6_7WK_UP	197	135	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_XPCS_DN	88	71	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_TTD_DN	84	63	All SZGR genes in this pathway
ROVERSI_GLIOMA_COPY_NUMBER_DN	54	37	All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN	712	443	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	855	609	All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4	261	153	All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP	811	508	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN	514	330	All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS	988	594	All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS	290	172	All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS	734	436	All SZGR genes in this pathway
BENPORATH_NOS_TARGETS	179	105	All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS	1038	678	All SZGR genes in this pathway
BENPORATH_EED_TARGETS	1062	725	All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3	1118	744	All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS	652	441	All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP	195	138	All SZGR genes in this pathway
PETRETTO_HEART_MASS_QTL_CIS_DN	24	15	All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_3	28	23	All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP	555	346	All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP	182	119	All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP	314	201	All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR	544	307	All SZGR genes in this pathway
NIELSEN_GIST_AND_SYNOVIAL_SARCOMA_DN	20	15	All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN	830	547	All SZGR genes in this pathway
LU_AGING_BRAIN_UP	262	186	All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_UP	222	139	All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP	487	303	All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP	268	157	All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP	953	554	All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN	1011	592	All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN	292	189	All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN	281	179	All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_UP	102	64	All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_UP	139	95	All SZGR genes in this pathway
ROSS_LEUKEMIA_WITH_MLL_FUSIONS	78	49	All SZGR genes in this pathway
MIKKELSEN_DEDIFFERENTIATED_STATE_DN	7	7	All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_UP	74	45	All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_UP	105	75	All SZGR genes in this pathway
YAGI_AML_WITH_T_9_11_TRANSLOCATION	130	87	All SZGR genes in this pathway
MIKKELSEN_MCV6_ICP_WITH_H3K4ME3_AND_H3K27ME3	34	21	All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K27ME3	42	27	All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3	445	257	All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL	177	132	All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN	1972	1213	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A	898	516	All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP	259	159	All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	1080	713	All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D	882	506	All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES	462	273	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	1017	1023	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-129-5p	925	931	1A	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	925	931	1A	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-130/301	300	306	m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-132/212	1303	1310	1A,m8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	1303	1310	1A,m8	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-138	766	772	m8	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-139	1018	1024	m8	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-140	525	531	1A	hsa-miR-140^brain	AGUGGUUUUACCCUAUGGUAG
miR-141/200a	775	782	1A,m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
				hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
				hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
				hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-142-3p	442	448	1A	hsa-miR-142-3p	UGUAGUGUUUCCUACUUUAUGGA
miR-142-3p	442	448	1A	hsa-miR-142-3p	UGUAGUGUUUCCUACUUUAUGGA
miR-144	1016	1023	1A,m8	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-153	689	695	1A	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-153	689	695	1A	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-19	762	768	m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	762	768	m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-192/215	956	963	1A,m8	hsa-miR-192	CUGACCUAUGAAUUGACAGCC
miR-192/215	956	963	1A,m8	hsa-miR-215	AUGACCUAUGAAUUGACAGAC
miR-200bc/429	392	398	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
				hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
				hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
				hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
				hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-205	564	570	1A	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-205	564	570	1A	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-208	608	614	1A	hsa-miR-208	AUAAGACGAGCAAAAAGCUUGU
miR-218	275	282	1A,m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-221/222	1421	1427	m8	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
miR-221/222	1421	1427	m8	hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-25/32/92/363/367	858	864	m8	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-26	571	577	1A	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	571	577	1A	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-27	561	567	1A	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	561	567	1A	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-30-3p	1257	1264	1A,m8	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
miR-30-3p	1257	1264	1A,m8	hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
miR-30-5p	844	850	1A	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-323	431	437	m8	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-342	1146	1152	1A	hsa-miR-342^brain	UCUCACACAGAAAUCGCACCCGUC
miR-369-3p	1364	1370	m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-369-3p	1364	1370	m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	1032	1038	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-377	586	593	1A,m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-409-5p	523	529	1A	hsa-miR-409-5p	AGGUUACCCGAGCAACUUUGCA
miR-448	688	695	1A,m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-448	688	695	1A,m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-452	691	697	m8	hsa-miR-452	UGUUUGCAGAGGAAACUGAGAC
miR-485-3p	1318	1324	m8	hsa-miR-485-3p	GUCAUACACGGCUCUCCUCUCU
miR-499	607	614	1A,m8	hsa-miR-499	UUAAGACUUGCAGUGAUGUUUAA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.