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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 2810 |
Name | SFN |
Synonym | YWHAS;stratifin;SFN;stratifin |
Definition | 14-3-3 protein sigma|14-3-3 sigma|epithelial cell marker protein 1 |
Position | 1p36.11 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
reviewed | The present immunohistochemical study confirmed 14-3-3sigma as a tumor suppressor in breast carcinogenesis. |
reviewed | Stratifin was first identified as an epithelial cell antigen exclusively expressed in epithelia. the functional role of sfn in cell proliferation and apoptosis could be relevant to the regulation of growth and differentiation as a tumor suppressor gene. |
| More detail of all 2 literatures about SFN | |
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Pathways and Diseases |
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Pathway | p53 pathway;PANTHER;P00059 |
Pathway | Parkinson disease;PANTHER;P00049 |
Pathway | Glucocorticoid receptor regulatory network;PID Curated;200077 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | estrogen responsive protein efp controls cell cycle and breast tumors growth;PID BioCarta;100182 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | FGF signaling pathway;PANTHER;P00021 |
Pathway | Aldosterone-regulated sodium reabsorption;KEGG PATHWAY;hsa04960 |
Pathway | cell cycle: g2/m checkpoint;PID BioCarta;100159 |
Disease | CANCER;GAD |
Disease | 5' CpG island hypermethylation;GAD |
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External Links |
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Links to Entrez Gene | 2810 |
Links to all GeneRIF Items | 2810 |
Links to iHOP | 2810 |
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Sequence Information |
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Nucleotide Sequence |
>2810 : length: 747 atggagagagccagtctgatccagaaggccaagctggcagagcaggccgaacgctatgag gacatggcagccttcatgaaaggcgccgtggagaagggcgaggagctctcctgcgaagag cgaaacctgctctcagtagcctataagaacgtggtgggcggccagagggctgcctggagg gtgctgtccagtattgagcagaaaagcaacgaggagggctcggaggagaaggggcccgag gtgcgtgagtaccgggagaaggtggagactgagctccagggcgtgtgcgacaccgtgctg ggcctgctggacagccacctcatcaaggaggccggggacgccgagagccgggtcttctac ctgaagatgaagggtgactactaccgctacctggccgaggtggccaccggtgacgacaag aagcgcatcattgactcagcccggtcagcctaccaggaggccatggacatcagcaagaag gagatgccgcccaccaaccccatccgcctgggcctggccctgaacttttccgtcttccac tacgagatcgccaacagccccgaggaggccatctctctggccaagaccactttcgacgag gccatggctgatctgcacaccctcagcgaggactcctacaaagacagcaccctcatcatg cagctgctgcgagacaacctgacactgtggacggccgacaacgccggggaagaggggggc gaggctccccaggagccccagagctga |
Protein Sequence |
>2810 : length: 248 MERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWR VLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFY LKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFH YEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWTADNAGEEGG EAPQEPQS |