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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 2810 |
Name | SFN |
Synonymous | YWHAS;stratifin;SFN;stratifin |
Definition | 14-3-3 protein sigma|14-3-3 sigma|epithelial cell marker protein 1 |
Position | 1p36.11 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
Cdk1(h) + 14-3-3sigma(h) <==> Cdk1(h):14-3-3sigma(h) (binding) | Cdk2(h) + 14-3-3sigma(h) <==> Cdk2(h):14-3-3sigma(h) (binding) | 14-3-3sigma(h) + ATP --JNK1beta1(r)--> 14-3-3sigma(h){pS186} + ADP (phosphorylation) | 14-3-3sigma(h) + Bax(m) <==> 14-3-3sigma(h):Bax(m) (binding) | ErbB1(h) + 14-3-3sigma(h) <==> ErbB1(h):14-3-3sigma(h) (binding) | 14-3-3sigma(h) + IRS-1(r) <==> 14-3-3sigma(h):IRS-1(r) (binding) | bad(h) + 14-3-3sigma(h) <==> bad(h):14-3-3sigma(h) (binding) | 14-3-3sigma(h) + CTAK1(h) <==> 14-3-3sigma(h):CTAK1(h) (binding) | 14-3-3sigma(h) + chst1(h) <==> 14-3-3sigma(h):chst1(h) (binding) | 14-3-3sigma(h) + c9orf61(h) <==> 14-3-3sigma(h):c9orf61(h) (binding) | 14-3-3sigma(h) + GRIN2(h) <==> 14-3-3sigma(h):GRIN2(h) (binding) | 14-3-3sigma(h) + FLJ43995(h) <==> 14-3-3sigma(h):FLJ43995(h) (binding) | 14-3-3sigma(h) + SAZD(h) <==> 14-3-3sigma(h):SAZD(h) (binding) | 14-3-3sigma(h) + plk4(h) <==> 14-3-3sigma(h):plk4(h) (binding) | 14-3-3sigma(h) + FLJ10204(h) <==> 14-3-3sigma(h):FLJ10204(h) (binding) | 14-3-3sigma(h) + plekhf2(h) <==> 14-3-3sigma(h):plekhf2(h) (binding) | SFN(h) --> 14-3-3sigma(h) (expression). | Apak(h) --/ 14-3-3sigma(h) (decrease of abundance) | GR-alpha(h) + 14-3-3sigma(h) <==> GR-alpha(h):14-3-3sigma(h) (binding) | 14-3-3sigma(h) + Rad(m) <==> 14-3-3sigma(h):Rad(m) (binding) | 14-3-3sigma(h) + Rem1(m) <==> 14-3-3sigma(h):Rem1(m) (binding) | p27Kip1(h) + 14-3-3sigma(h) <==> p27Kip1(h):14-3-3sigma(h) (binding) | 14-3-3sigma(h) + POB1-isoform2(h) <==> 14-3-3sigma(h):POB1-isoform2(h) (binding) | SFN(h) --> 14-3-3sigma(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
|
Location (AA) |
PTM type |
Literature |
Database |
64 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 216 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 248 | Phosphoserine. | Swiss-Prot 53.0 | 186 | Phosphoserine (MAPK8) | 15071501 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
|
Chromosome |
Location |
Source |
|---|---|---|
chr1 |
Promoter: 27060720 - 27062720 | GoldenGate_Methylation_Cancer_Panel_I |
chr1 |
Promoter: 27060720 - 27062720 | GSE27584 |
chr1 |
Promoter: 27060720 - 27062720 | Agilent_014791 |
chr1 |
Promoter: 27060720 - 27062720 | PMID:11077447 |
chr1 |
Promoter: 27060720 - 27062720 | PMID:12213730 |
chr1 |
Promoter: 27060720 - 27062720 | PMID:17192910 |
chr1 |
Promoter: 27060720 - 27062720 | PMID:15899813 |
chr1 |
Promoter: 27060720 - 27062720 | PMID:16964403 |
chr1 |
Promoter: 27060720 - 27062720 | PMID:17264521 |
chr1 |
Promoter: 27060720 - 27062720 | PMID:15713962 |