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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 5777 |
Name | PTPN6 |
Synonym | HCP|HCPH|HPTP1C|PTP-1C|SH-PTP1|SHP-1|SHP-1L|SHP1;protein tyrosine phosphatase, non-receptor type 6;PTPN6;protein tyrosine phosphatase, non-receptor type 6 |
Definition | hematopoietic cell phosphatase|hematopoietic cell protein-tyrosine phosphatase|protein-tyrosine phosphatase 1C|protein-tyrosine phosphatase SHP-1|tyrosine-protein phosphatase non-receptor type 6 |
Position | 12p13 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 2 PubMed records as below. |
|
Evidence Status |
Description |
potential | Results support the notion that the tumor suppressor effects of SHP1 on NPM-ALK are dependent on its ability to bind to this oncogenic protein. |
reviewed | STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes. |
| More detail of all 2 literatures about PTPN6 | |
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Pathways and Diseases |
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Pathway | il-2 receptor beta chain in t cell activation;PID BioCarta;100129 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | B cell receptor signaling pathway;KEGG PATHWAY;hsa04662 |
Pathway | ras-independent pathway in nk cell-mediated cytotoxicity;PID BioCarta;100095 |
Pathway | Interferon-gamma signaling pathway;PANTHER;P00035 |
Pathway | CXCR4-mediated signaling events;PID Curated;200083 |
Pathway | FGF signaling pathway;PANTHER;P00021 |
Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | Adherens junction;KEGG PATHWAY;hsa04520 |
Pathway | IL4-mediated signaling events;PID Curated;200018 |
Pathway | il 3 signaling pathway;PID BioCarta;100128 |
Pathway | PECAM1 interactions;PID Reactome;500307 |
Pathway | EPO signaling pathway;PID Curated;200157 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | EGF receptor (ErbB1) signaling pathway;PID Curated;200085 |
Pathway | growth hormone signaling pathway;PID BioCarta;100155 |
Pathway | epo signaling pathway;PID BioCarta;100175 |
Pathway | Interactions of the immunoglobulin superfamily (IgSF) member proteins;Reactome;REACT:23853 |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Cell junction organization;Reactome;REACT:20676 |
Pathway | Jak-STAT signaling pathway;KEGG PATHWAY;hsa04630 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | TCR signaling in naive CD8+ T cells;PID Curated;200062 |
Pathway | Leishmaniasis;KEGG PATHWAY;hsa05140 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Disease | Leukemia;FunDO |
Disease | Anemia;FunDO |
Disease | Cancer;FunDO |
Disease | Multiple sclerosis;FunDO |
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External Links |
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Links to Entrez Gene | 5777 |
Links to all GeneRIF Items | 5777 |
Links to iHOP | 5777 |
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Sequence Information |
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Nucleotide Sequence |
>5777 : length: 1788 atggtgaggtggtttcaccgagacctcagtgggctggatgcagagaccctgctcaagggc cgaggtgtccacggtagcttcctggctcggcccagtcgcaagaaccagggtgacttctcg ctctccgtcagggtgggggatcaggtgacccatattcggatccagaactcaggggatttc tatgacctgtatggaggggagaagtttgcgactctgacagagctggtggagtactacact cagcagcagggtgtcctgcaggaccgcgacggcaccatcatccacctcaagtacccgctg aactgctccgatcccactagtgagaggtggtaccatggccacatgtctggcgggcaggca gagacgctgctgcaggccaagggcgagccctggacgtttcttgtgcgtgagagcctcagc cagcctggagacttcgtgctttctgtgctcagtgaccagcccaaggctggcccaggctcc ccgctcagggtcacccacatcaaggtcatgtgcgagggtggacgctacacagtgggtggt ttggagaccttcgacagcctcacggacctggtggagcatttcaagaagacggggattgag gaggcctcaggcgcctttgtctacctgcggcagccgtactatgccacgagggtgaatgcg gctgacattgagaaccgagtgttggaactgaacaagaagcaggagtccgaggatacagcc aaggctggcttctgggaggagtttgagagtttgcagaagcaggaggtgaagaacttgcac cagcgtctggaagggcagcggccagagaacaagggcaagaaccgctacaagaacattctc ccctttgaccacagccgagtgatcctgcagggacgggacagtaacatccccgggtccgac tacatcaatgccaactacatcaagaaccagctgctaggccctgatgagaacgctaagacc tacatcgccagccagggctgtctggaggccacggtcaatgacttctggcagatggcgtgg caggagaacagccgtgtcatcgtcatgaccacccgagaggtggagaaaggccggaacaaa tgcgtcccatactggcccgaggtgggcatgcagcgtgcttatgggccctactctgtgacc aactgcggggagcatgacacaaccgaatacaaactccgtaccttacaggtctccccgctg gacaatggagacctgattcgggagatctggcattaccagtacctgagctggcccgaccat ggggtccccagtgagcctgggggtgtcctcagcttcctggaccagatcaaccagcggcag gaaagtctgcctcacgcagggcccatcatcgtgcactgcagcgccggcatcggccgcaca ggcaccatcattgtcatcgacatgctcatggagaacatctccaccaagggcctggactgt gacattgacatccagaagaccatccagatggtgcgggcgcagcgctcgggcatggtgcag acggaggcgcagtacaagttcatctacgtggccatcgcccagttcattgaaaccactaag aagaagctggaggtcctgcagtcgcagaagggccaggagtcggagtacgggaacatcacc tatcccccagccatgaagaatgcccatgccaaggcctcccgcacctcgtccaaacacaag gaggatgtgtatgagaacctgcacactaagaacaagagggaggagaaagtgaagaagcag cggtcagcagacaaggagaagagcaagggttccctcaagaggaagtga |
Protein Sequence |
>5777 : length: 595 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT YPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK |