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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 5777 |
Name | PTPN6 |
Synonymous | HCP|HCPH|HPTP1C|PTP-1C|SH-PTP1|SHP-1|SHP-1L|SHP1;protein tyrosine phosphatase, non-receptor type 6;PTPN6;protein tyrosine phosphatase, non-receptor type 6 |
Definition | hematopoietic cell phosphatase|hematopoietic cell protein-tyrosine phosphatase|protein-tyrosine phosphatase 1C|protein-tyrosine phosphatase SHP-1|tyrosine-protein phosphatase non-receptor type 6 |
Position | 12p13 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
p120CAS 3A(h){pY} + SHP-1(h) <==> p120CAS 3A(h){pY}:SHP-1(h) (binding) | ROS(m){pY} + SHP-1(h) <==> ROS(m){pY}:SHP-1(h) (binding) | c-Kit(m){pY569} + SHP-1(h) <==> c-Kit(m){pY569}:SHP-1(h) (binding) | IL-4Ralpha(h) + SHP-1(h) <==> IL-4Ralpha(h):SHP-1(h) (binding) | SHP-1(h) + p85(h) <==> SHP-1(h):p85(h) (binding) | EpoR(m){pY429} + SHP-1(h) <==> EpoR(m){pY429}:SHP-1(h) (binding) | FcgammaRIIB(m){pY309} + SHP-1(h) <==> FcgammaRIIB(m){pY309}:SHP-1(h) (binding) | CD22(h){pY} + SHP-1(h) <==> CD22(h){pY}:SHP-1(h) (binding) | CD22(h){pY} + Syk(h){pY} + SHP-1(h) <==> CD22(h){pY}:Syk(h){pY}:SHP-1(h) (binding) | Syk(h){pY} + CD22(h){pY} + SHP-1(h) + PLCgamma1(h) <==> Syk(h){pY}:CD22(h){pY}:SHP-1(h):PLCgamma1(h) (binding) | SHP-1(h) --> p120CAS(h) (decrease of phosphorylation) | SHP-1(h) + NKAT1(h){p} + NTP --> SHP-1(h){pY}:NKAT1(h){p} + NDP (phosphorylation; binding) | Abl(m.s.) + SHP-1(h) + NTP --> Abl(m.s.):SHP-1(h){pY}{pY536} + NDP (phosphorylation; binding) | SHP-1(h) + Pyk2(h) <==> SHP-1(h):Pyk2(h) (binding) | SHP-1(h) --> Syk(h) (binding) | SHP-1(h) --> PLCgamma1(h) (binding) | beta-catenin(h){p} + SHP-1(h) --> SHP-1(h):beta-catenin(h) + p (dephosphorylation; binding) | SHP-1(h) + MCP(h) <==> SHP-1(h):MCP(h) (binding) | SHP-1(h) + caveolin-1(h) <==> SHP-1(h):caveolin-1(h) (binding) | Ret(m.s.){p} + SHP-1(h) <==> Ret(m.s.){p}:SHP-1(h) (binding) | Ret(h) + SHP-1(h) <==> Ret(h):SHP-1(h) (binding) | SHP-1(h) --> alpha-actinin-1(h) (decrease of phosphorylation) | SHP-1(h) + LAT(h) <==> SHP-1(h):LAT(h) (binding) | LAIR1(h) + SHP-1(h) <==> LAIR1(h):SHP-1(h) (binding) | LAIR1(h){pY233}{pY263} + SHP-1(h) <==> LAIR1(h){pY233}{pY263}:SHP-1(h) (binding) | PKCalpha(h) + SHP-1(h) <==> PKCalpha(h):SHP-1(h) (binding) | Vav(h) + SHP-1(h) <==> Vav(h):SHP-1(h) (binding) | SHP-1(h) --> SHP-1(h) (translocation) | SHP-1(h) + KLRD1(h):NKG2-A(h){pY} <==> SHP-1(h):KLRD1(h):NKG2-A(h){pY} (binding) | ErbB1-p170(h){pY998} + SHP-1(h) <==> ErbB1-p170(h){pY998}:SHP-1(h) (binding) | ErbB2(h){pY1023}{pY1222} + SHP-1(h) <==> ErbB2(h){pY1023}{pY1222}:SHP-1(h) (binding) | SHP-1(h) + ErbB1(h){pY} <==> SHP-1(h):ErbB1(h){pY} (binding) | SHP-1(h) + LAIR(h) <==> SHP-1(h):LAIR(h) (binding) | CD244(m.s.){pY} + SHP-1(h) <==> CD244(m.s.){pY}:SHP-1(h) (binding) | BTLA1(h) + SHP-1(h) <==> BTLA1(h):SHP-1(h) (binding) | SHP-1(h) + CD244(h) <==> SHP-1(h):CD244(h) (binding) | IRp60(h) + SHP-1(h) <==> IRp60(h):SHP-1(h) (binding) | SHP-1(h) --/ IGF1(h) (transrepression) | UV --/ SHP-1(h) (inhibition) | ROS(m):SHP-1(h) <==> ROS(m) + SHP-1(h) (dissociation) | PTPN6(h) --> SHP-1(h) (expression). | CD22(h){pY} --> SHP-1(h) (binding) | SHP-1(h) --> SHP-1(h) (translocation) | ErbB1(h){pY} --SHP-1(h)--> ErbB1(h) + p (dephosphorylation) | GHR(rb){pY} --SHP-1(h)--> GHR(rb) + p (dephosphorylation) | SHP1-isoform1(h) + ATP --PKCalpha(h)--> SHP1-isoform1(h){pS591} + ADP (phosphorylation) | SHP1-isoform1(h) + ATP --PKC(h)--> SHP1-isoform1(h){pS591} + ADP (phosphorylation) | SHP1-isoform1(h) + ATP --> SHP1-isoform1(h){pY} + ADP (phosphorylation) | SHP1-isoform1(h) + PKCalpha(h) <==> SHP1-isoform1(h):PKCalpha(h) (binding) | SHP1-isoform1(h) + ATP --> SHP1-isoform1(h){pY564} + ADP (phosphorylation) | PTPN6(h) --> SHP1-isoform1(h) (expression). | Cd72(m){pY} --SHP1-isoform1(h)--> Cd72(m) + p (dephosphorylation) | ZAP-70(h){pY} --SHP1-isoform1(h)--> ZAP-70(h) + p (dephosphorylation) | SHP1-isoform2(h) + ErbB1(h) <==> SHP1-isoform2(h):ErbB1(h) (binding) | ErbB1-p170(h){pY1197} + SHP1-isoform2(h) <==> SHP1-isoform2(h):ErbB1-p170(h){pY1197} (binding) | SHP1-isoform2(h) + ErbB1(h){pY} <==> SHP1-isoform2(h):ErbB1(h){pY} (binding) | PTPN6(h) --> SHP1-isoform2(h) (expression). | ErbB1(h){pY} --SHP1-isoform2(h)--> ErbB1(h) + p (dephosphorylation) | PTPN6(h) --> SHP1-isoform3(h) (expression). | PTPN6(h) --> SHP-1L(h) (expression). | ZAP-70(h){pY} --SHP-1L(h)--> ZAP-70(h) + p (dephosphorylation) |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
564 | Phosphotyrosine (Lck;Abl;Src) | 12468540;8114715;8692915;14757045;14699166;1048809 | Phospho.ELM 6.0 | 536 | Phosphotyrosine (Lck;Abl;Src;) | 12468540;8114715;8692915;7512963;14757045;14699166 | Phospho.ELM 6.0 | 591 | Phosphoserine (PKC alpha) | 15269224 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
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chr12 |
Promoter: 6924501 - 6926501 | GoldenGate_Methylation_Cancer_Panel_I |
chr12 |
Promoter: 6929204 - 6931204 | GSE27584 |
chr12 |
Promoter: 6924501 - 6926501 | GSE27584 |
chr12 |
Promoter: 6929204 - 6931204 | PMID:15801956 |
chr12 |
Promoter: 6924501 - 6926501 | PMID:15801956 |