Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

5777

Name

PTPN6

Synonymous

HCP|HCPH|HPTP1C|PTP-1C|SH-PTP1|SHP-1|SHP-1L|SHP1;protein tyrosine phosphatase, non-receptor type 6;PTPN6;protein tyrosine phosphatase, non-receptor type 6

Definition

hematopoietic cell phosphatase|hematopoietic cell protein-tyrosine phosphatase|protein-tyrosine phosphatase 1C|protein-tyrosine phosphatase SHP-1|tyrosine-protein phosphatase non-receptor type 6

Position

12p13

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction

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Interaction Type

Interactor

Data Source

interacts with

 LYNBIOGRID; PUBMED:10574931;

interacts with

 NOS1BIOGRID; PUBMED:11511520;

interacts with

 SYKBIOGRID; PUBMED:10072516;

interacts with

 SYKBIOGRID; PUBMED:10747947;

interacts with

 PRKCDBIOGRID; PUBMED:11723252;

interacts with

 LILRB4BIOGRID; PUBMED:9973385;

interacts with

 LCKBIOGRID; PUBMED:10617656;

interacts with

 LCKBIOGRID; PUBMED:11294838;

interacts with

 LCKBIOGRID; PUBMED:8114715;

interacts with

 KITBIOGRID; PUBMED:7684496;

interacts with

 KITBIOGRID; PUBMED:9528781;

interacts with

 LAIR1BIOGRID; PUBMED:10660620;

interacts with

 LAIR1BIOGRID; PUBMED:10764762;

interacts with

 LAIR1BIOGRID; PUBMED:10903717;

interacts with

 LAIR1BIOGRID; PUBMED:11160222;

interacts with

 LAIR1BIOGRID; PUBMED:9285412;

interacts with

 LIFRBIOGRID; PUBMED:10800945;

interacts with

 LILRB2BIOGRID; PUBMED:9531263;

interacts with

 LILRB2BIOGRID; PUBMED:9842885;

interacts with

 LILRB1BIOGRID; PUBMED:9842885;

interacts with

 LCP2BIOGRID; PUBMED:8760799;

interacts with

 LCP2BIOGRID; PUBMED:9765283;

interacts with

 BLNKBIOGRID; PUBMED:11356834;

interacts with

 EGFRBIOGRID; PUBMED:7673163;

interacts with

 EGFRBIOGRID; PUBMED:9733788;

interacts with

 CAV1BIOGRID; PUBMED:12176037;

interacts with

 GAB2BIOGRID; PUBMED:11895767;

interacts with

 G6BBIOGRID; PUBMED:11544253;

interacts with

 PTK2BBIOGRID; PUBMED:10521452;

interacts with

 PTK2BBIOGRID; PUBMED:10747947;

interacts with

 FCRL3BIOGRID; PUBMED:12051764;

interacts with

 EPORBIOGRID; PUBMED:7889566;

interacts with

 CD33BIOGRID; PUBMED:10206955;

interacts with

 CD22BIOGRID; PUBMED:10228003;

interacts with

 CD22BIOGRID; PUBMED:11356834;

interacts with

 CD22BIOGRID; PUBMED:11551923;

interacts with

 CD22BIOGRID; PUBMED:8627166;

interacts with

 CD22BIOGRID; PUBMED:9890995;

interacts with

 CTNND1BIOGRID; PUBMED:10835420;

interacts with

 CXCR4BIOGRID; PUBMED:10506573;

interacts with

 JAK2BIOGRID; PUBMED:10772872;

interacts with

 JAK2BIOGRID; PUBMED:8943354;

interacts with

 CBLBIOGRID; PUBMED:12176909;

interacts with

 IL6STBIOGRID; PUBMED:10800945;

interacts with

 IL4RBIOGRID; PUBMED:11714803;

interacts with

 CSF2RBBIOGRID; PUBMED:8246974;

interacts with

 CSF2RBBIOGRID; PUBMED:9162089;

interacts with

 JAK1BIOGRID; PUBMED:7629131;

interacts with

 ROS1BIOGRID; PUBMED:11266449;

interacts with

 INSRBIOGRID; PUBMED:7512963;

interacts with

 ABL1BIOGRID; PUBMED:8692915;

interacts with

 PECAM1BIOGRID; PUBMED:10350061;

interacts with

 PECAM1BIOGRID; PUBMED:9774457;

interacts with

 PILRABIOGRID; PUBMED:10660620;

interacts with

 PILRABIOGRID; PUBMED:10903717;

interacts with

 HOXA10BIOGRID; PUBMED:12145285;

interacts with

 SSTR2BIOGRID; PUBMED:9305905;

interacts with

 SOS1BIOGRID; PUBMED:8632004;

interacts with

 STAT5BBIOGRID; PUBMED:9211920;

interacts with

 SLAMF6BIOGRID; PUBMED:11489943;

interacts with

 ZAP70BIOGRID; PUBMED:8638162;

interacts with

 TREML1BIOGRID; PUBMED:12393607;

interacts with

 VAV1BIOGRID; PUBMED:8632004;

interacts with

 TYK2BIOGRID; PUBMED:7629131;

interacts with

 SIGLEC11BIOGRID; PUBMED:11986327;

interacts with

 SIRPABIOGRID; PUBMED:10660565;

interacts with

 SIRPABIOGRID; PUBMED:10660620;

interacts with

 CD5BIOGRID; PUBMED:10082557;

interacts with

 PAG1BIOGRID; PUBMED:10790433;

interacts with

 PIK3R1BIOGRID; PUBMED:11160222;

interacts with

 CD72BIOGRID; PUBMED:11114375;

interacts with

 CD72BIOGRID; PUBMED:12882840;

interacts with

 CD72BIOGRID; PUBMED:9590210;

interacts with

 EGFRCELL_MAP; PUBMED:7673163;

interacts with

 CTNND1CELL_MAP; PUBMED:10835420;

interacts with

 LYNHPRD; PUBMED:10574931;

interacts with

 TFGHPRD; PUBMED:15557341;

interacts with

 TRAF6HPRD; PUBMED:14500659;

interacts with

 TMEM62HPRD; PUBMED:16169070;

interacts with

 TNFRSF1AHPRD; PUBMED:11786908;

interacts with

 KLRC1HPRD; PUBMED:9485206;

interacts with

 MYH9HPRD; PUBMED:12705885;

interacts with

 NOS1HPRD; PUBMED:11511520;

interacts with

 SYKHPRD; PUBMED:10072516;

interacts with

 KLRB1HPRD; PUBMED:10229828;

interacts with

 PRKCDHPRD; PUBMED:11723252;

interacts with

 LILRB4HPRD; PUBMED:9151699;

interacts with

 LCKHPRD; PUBMED:8114715;

interacts with

 KITHPRD; PUBMED:7684496;

interacts with

 LAIR1HPRD; PUBMED:11160222;

interacts with

 PRKCAHPRD; PUBMED:15269224;

interacts with

 KIR2DL3HPRD; PUBMED:9148918;

interacts with

 KIR2DL5AHPRD; PUBMED:15187115;

interacts with

 LIFRHPRD; PUBMED:10800945;

interacts with

 LILRB2HPRD; PUBMED:9842885;

interacts with

 KHDRBS1HPRD; PUBMED:9045636;

interacts with

 LCP2HPRD; PUBMED:9765283;

interacts with

 BTLAHPRD; PUBMED:12796776;

interacts with

 BLNKHPRD; PUBMED:11356834;

interacts with

 DOK1HPRD; PUBMED:10585470;

interacts with

 ESR1HPRD; PUBMED:7539106;

interacts with

 EGFRHPRD; PUBMED:9733788;

interacts with

 GHRHPRD; PUBMED:9632636;

interacts with

 CAV1HPRD; PUBMED:12176037;

interacts with

 FCGR2BHPRD; PUBMED:7716523;

interacts with

 GAB2HPRD; PUBMED:11895767;

interacts with

 MS4A2HPRD; PUBMED:9379041;

interacts with

 PTK2BHPRD; PUBMED:10521452;

interacts with

 FLT3HPRD; PUBMED:15831474;

interacts with

 EPORHPRD; PUBMED:7889566;

interacts with

 CD79AHPRD; PUBMED:7539038;

interacts with

 CD33HPRD; PUBMED:10206955;

interacts with

 CTNND1HPRD; PUBMED:10835420;

interacts with

 CUZD1HPRD; PUBMED:12361947;

interacts with

 CTNNB1HPRD; PUBMED:12571228;

interacts with

 CXCR4HPRD; PUBMED:10506573;

interacts with

 JAK2HPRD; PUBMED:8943354;

interacts with

 CBLHPRD; PUBMED:12176909;

interacts with

 IL2RBHPRD; PUBMED:9520455;

interacts with

 IL6STHPRD; PUBMED:10800945;

interacts with

 CEACAM1HPRD; PUBMED:9867848;

interacts with

 IL4RHPRD; PUBMED:11714803;

interacts with

 IRS2HPRD; PUBMED:12198247;

interacts with

 CSF2RBHPRD; PUBMED:8246974;

interacts with

 JAK1HPRD; PUBMED:7629131;

interacts with

 PTPRCHPRD; PUBMED:10228003;

interacts with

 ROS1HPRD; PUBMED:11266449;

interacts with

 JAK3HPRD; PUBMED:9520455;

interacts with

 ACTN4HPRD; PUBMED:15070900;

interacts with

 ACTN1HPRD; PUBMED:15070900;

interacts with

 INSRHPRD; PUBMED:7512963;

interacts with

 IFNAR1HPRD; PUBMED:9029147;

interacts with

 PECAM1HPRD; PUBMED:9774457;

interacts with

 IRS4HPRD; PUBMED:12774026;

interacts with

 PILRAHPRD; PUBMED:10660620;

interacts with

 PILRBHPRD; PUBMED:9632768;

interacts with

 PTPN11HPRD; PUBMED:8541543;

interacts with

 CD247HPRD; PUBMED:14672952;

interacts with

 HOXA10HPRD; PUBMED:12145285;

interacts with

 SSTR2HPRD; PUBMED:9305905;

interacts with

 SPATA2HPRD; PUBMED:11160222;

interacts with

 SRCHPRD; PUBMED:12468645;

interacts with

 SOS1HPRD; PUBMED:8632004;

interacts with

 STAT6HPRD; PUBMED:12791978;

interacts with

 STAT5BHPRD; PUBMED:9211920;

interacts with

 ZAP70HPRD; PUBMED:8638162;

interacts with

 TREML1HPRD; PUBMED:12393607;

interacts with

 KDRHPRD; PUBMED:9405464;

interacts with

 VAV1HPRD; PUBMED:8632004;

interacts with

 TYK2HPRD; PUBMED:7629131;

interacts with

 CD79BHPRD; PUBMED:7539038;

interacts with

 SIGLEC10HPRD; PUBMED:12163025;

interacts with

 SHC1HPRD; PUBMED:8541543;

interacts with

 SIGLEC12HPRD; PUBMED:11328818;

interacts with

 SIGLEC11HPRD; PUBMED:11986327;

interacts with

 SIRPAHPRD; PUBMED:10660565;

interacts with

 CD5HPRD; PUBMED:10082557;

interacts with

 PAG1HPRD; PUBMED:10790433;

interacts with

 PIK3R1HPRD; PUBMED:11337495;

interacts with

 CLEC4AHPRD; PUBMED:11178971;

interacts with

 CD300LFHPRD; PUBMED:15549731;

interacts with

 CD72HPRD; PUBMED:9590210;

interacts with

 MAP3K4MINT; PUBMED:15601262;

interacts with

 TFGMINT; PUBMED:15557341;

interacts with

 TNFRSF1AMINT; PUBMED:11786908;

interacts with

 KitMINT; PUBMED:9528781;

interacts with

 KIR2DL1MINT; PUBMED:8691146;

interacts with

 LAIR1MINT; PUBMED:10764762;

interacts with

 KIR2DL3MINT; PUBMED:8574854;

interacts with

 KIR2DL3MINT; PUBMED:8648092;

interacts with

 KIR2DL3MINT; PUBMED:8691154;

interacts with

 KIR2DL3MINT; PUBMED:9148918;

interacts with

 BTLAMINT; PUBMED:14652006;

interacts with

 ESR1MINT; PUBMED:7539106;

interacts with

 EGFRMINT; PUBMED:9733788;

interacts with

 CAV1MINT; PUBMED:12176037;

interacts with

 FCGR2BMINT; PUBMED:8577729;

interacts with

 FCGR2BMINT; PUBMED:9148918;

interacts with

 FCGR2BMINT; PUBMED:9603468;

interacts with

 G6BMINT; PUBMED:11544253;

interacts with

 EPORMINT; PUBMED:7228577;

interacts with

 EPORMINT; PUBMED:7528537;

interacts with

 EPORMINT; PUBMED:7528577;

interacts with

 CD33MINT; PUBMED:10206955;

interacts with

 CD33MINT; PUBMED:10556798;

interacts with

 Ros1MINT; PUBMED:11266449;

interacts with

 IL4RMINT; PUBMED:11714803;

interacts with

 IL4RMINT; PUBMED:9392697;

interacts with

 CSF2RBMINT; PUBMED:7528537;

interacts with

 CSF2RBMINT; PUBMED:9162089;

interacts with

 ROS1MINT; PUBMED:11266449;

interacts with

 ROS1MINT; PUBMED:17416557;

interacts with

 SH3BP2MINT; PUBMED:16649996;

interacts with

 PECAM1MINT; PUBMED:9774457;

interacts with

 PILRAMINT; PUBMED:10660620;

interacts with

 SIGLEC10MINT; PUBMED:12163025;

interacts with

 PDCD1MINT; PUBMED:15240681;

interacts with

 PIK3R1MINT; PUBMED:10488096;

interacts with

 CD300LFMINT; PUBMED:15549731;

Metabolic Interaction

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There is no record for PTPN6

Signaling Interaction

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Interaction Type

Interactor

Data Source

state change

 EGFRCELL_MAP; PUBMED:7518460;

state change

 PTPN6CELL_MAP; PUBMED:7518460;

reacts with

 LYNNCI_NATURE; PUBMED:11356834;

reacts with

 SYKNCI_NATURE; PUBMED:11356834;

state change

 LCKNCI_NATURE; PUBMED:8114715;

state change

 CD4NCI_NATURE; PUBMED:8114715;

reacts with

 BLNKNCI_NATURE; PUBMED:11356834;

state change

 B2MNCI_NATURE; PUBMED:8114715;

reacts with

 BTKNCI_NATURE; PUBMED:11356834;

state change

 EGFRNCI_NATURE; PUBMED:7673163;PUBMED:9733788;PUBMED:9038217;

state change

 EPONCI_NATURE; PUBMED:7528577;

state change

 EGFNCI_NATURE; PUBMED:7673163;PUBMED:9733788;PUBMED:9038217;

state change

 EPORNCI_NATURE; PUBMED:7528577;

state change

 HLA-DRANCI_NATURE; PUBMED:8114715;

state change

 CD3ENCI_NATURE; PUBMED:8114715;

reacts with

 CD79ANCI_NATURE; PUBMED:11356834;

state change

 CD8BNCI_NATURE; PUBMED:8114715;

state change

 CD22NCI_NATURE; PUBMED:7618087;PUBMED:7542197;

state change

 JAK2NCI_NATURE; PUBMED:7528577;

reacts with

 IL4RNCI_NATURE; PUBMED:11714803;PUBMED:9065461;

reacts with

 IL2RGNCI_NATURE; PUBMED:11714803;PUBMED:9065461;

reacts with

 JAK1NCI_NATURE; PUBMED:11714803;PUBMED:9065461;

reacts with

 JAK3NCI_NATURE; PUBMED:11714803;PUBMED:9065461;

state change

 HLA-ANCI_NATURE; PUBMED:8114715;

state change

 HLA-DRB1NCI_NATURE; PUBMED:8114715;

state change

 CD3DNCI_NATURE; PUBMED:8114715;

reacts with

 IL4NCI_NATURE; PUBMED:11714803;PUBMED:9065461;

reacts with

 PLCG2NCI_NATURE; PUBMED:11356834;

reacts with

 PTPN6NCI_NATURE; PUBMED:11356834;

reacts with

 PTPN6NCI_NATURE; PUBMED:11714803;PUBMED:9065461;

state change

 CD247NCI_NATURE; PUBMED:8114715;

state change

 CD3GNCI_NATURE; PUBMED:8114715;

reacts with

 CD79BNCI_NATURE; PUBMED:11356834;

state change

 CD8ANCI_NATURE; PUBMED:8114715;

reacts with

 CD72NCI_NATURE; PUBMED:11356834;

reacts with

 KITREACTOME; PUBMED:16129412;PUBMED:9528781;PUBMED:7684496;

reacts with

 GHRREACTOME; PUBMED:9111009;

state change

 GHRREACTOME; PUBMED:9111009;

reacts with

 JAK2REACTOME; PUBMED:9111009;

state change

 JAK2REACTOME; PUBMED:9111009;

reacts with

 PECAM1REACTOME; PUBMED:10350061;PUBMED:9774457;

reacts with

 PTPN6REACTOME; PUBMED:10207047;PUBMED:9108392;PUBMED:7898932;PUBMED:10194451;

reacts with

 PTPN6REACTOME; PUBMED:10350061;PUBMED:9774457;

reacts with

 PTPN6REACTOME; PUBMED:16129412;PUBMED:9528781;PUBMED:7684496;

reacts with

 PTPN6REACTOME; PUBMED:9111009;

state change

 PTPN6REACTOME; PUBMED:9111009;

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