VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
---|---|---|---|---|---|---|---|---|
TVIS10039668 | HBV | ENSG00000055118.18 | protein_coding | KCNH2 | No | No | 3757 | A0A090N7W1 A0A090N7X5 A0A090N8Q0 Q12809 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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Gene | KCNH2 |
---|---|
DrugBank ID | DB00472 |
Drug Name | Fluoxetine |
Target ID | BE0000090 |
UniProt ID | Q12809 |
Regulation Type | inhibitor |
PubMed IDs | 15272206; 16967046 |
Citations | Chiu PJ, Marcoe KF, Bounds SE, Lin CH, Feng JJ, Lin A, Cheng FC, Crumb WJ, Mitchell R: Validation of a [3H]astemizole binding assay in HEK293 cells expressing HERG K+ channels. J Pharmacol Sci. 2004 Jul;95(3):311-9.@@Rajamani S, Eckhardt LL, Valdivia CR, Klemens CA, Gillman BM, Anderson CL, Holzem KM, Delisle BP, Anson BD, Makielski JC, January CT: Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine. Br J Pharmacol. 2006 Nov;149(5):481-9. doi: 10.1038/sj.bjp.0706892. Epub 2006 Sep 11. |
Groups | Approved; Vet_approved |
Direct Classification | Trifluoromethylbenzenes |
SMILES | CNCCC(OC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1 |
Pathways | Fluoxetine Metabolism Pathway; Fluoxetine Action Pathway |
PharmGKB | PA449673 |
ChEMBL | CHEMBL41 |