Target Gene Table
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS10039668HBVENSG00000055118.18protein_codingKCNH2NoNo3757A0A090N7W1
A0A090N7X5
A0A090N8Q0
Q12809
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Drug Information
GeneKCNH2
DrugBank IDDB00472
Drug NameFluoxetine
Target IDBE0000090
UniProt IDQ12809
Regulation Typeinhibitor
PubMed IDs15272206; 16967046
CitationsChiu PJ, Marcoe KF, Bounds SE, Lin CH, Feng JJ, Lin A, Cheng FC, Crumb WJ, Mitchell R: Validation of a [3H]astemizole binding assay in HEK293 cells expressing HERG K+ channels. J Pharmacol Sci. 2004 Jul;95(3):311-9.@@Rajamani S, Eckhardt LL, Valdivia CR, Klemens CA, Gillman BM, Anderson CL, Holzem KM, Delisle BP, Anson BD, Makielski JC, January CT: Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine. Br J Pharmacol. 2006 Nov;149(5):481-9. doi: 10.1038/sj.bjp.0706892. Epub 2006 Sep 11.
GroupsApproved; Vet_approved
Direct ClassificationTrifluoromethylbenzenes
SMILESCNCCC(OC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1
PathwaysFluoxetine Metabolism Pathway; Fluoxetine Action Pathway
PharmGKBPA449673
ChEMBLCHEMBL41