Target Gene Table
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS10039668HBVENSG00000055118.18protein_codingKCNH2NoNo3757A0A090N7W1
A0A090N7X5
A0A090N8Q0
Q12809
TCGA Plot Options
Drug Information
GeneKCNH2
DrugBank IDDB01182
Drug NamePropafenone
Target IDBE0000090
UniProt IDQ12809
Regulation Typeinhibitor
PubMed IDs11330342; 12618228; 11752352
CitationsMergenthaler J, Haverkamp W, Huttenhofer A, Skryabin BV, Musshoff U, Borggrefe M, Speckmann EJ, Breithardt G, Madeja M: Blocking effects of the antiarrhythmic drug propafenone on the HERG potassium channel. Naunyn Schmiedebergs Arch Pharmacol. 2001 Apr;363(4):472-80.@@Arias C, Gonzalez T, Moreno I, Caballero R, Delpon E, Tamargo J, Valenzuela C: Effects of propafenone and its main metabolite, 5-hydroxypropafenone, on HERG channels. Cardiovasc Res. 2003 Mar;57(3):660-9.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.
GroupsApproved
Direct ClassificationLinear 1,3-diarylpropanoids
SMILESCCCNCC(O)COC1=C(C=CC=C1)C(=O)CCC1=CC=CC=C1
Pathways
PharmGKBPA451131
ChEMBLCHEMBL631