Gene: PARD3B

117583
ALS2CR19|PAR3B|PAR3L|PAR3beta
par-3 family cell polarity regulator beta
protein-coding
2q33.3
Ensembl:ENSG00000116117 Vega:OTTHUMG00000154562 UniprotKB:Q8TEW8
NC_000002.12
SNP Mapped
4   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.182e-1 (AD)  7.679e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11888554chr2:205231812 (GRCh38.p7)C>A / C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs849118chr2:205160450 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2082622chr2:205039410 (GRCh38.p7)C>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs7589114chr2:204911060 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLSCR40.871
CYBRD10.868
AHNAK0.863
PDLIM50.855
RIN20.853
IL17RD0.848
PPARA0.847
MAML20.839
GNG120.833
ANTXR10.832

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.614
CALHM1-0.608
ARL4D-0.608
B3GNT4-0.606
MCHR1-0.605
KCNB2-0.598
XKR7-0.593
RHO-0.588
GALNT14-0.587
ADRA1D-0.587

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PARD3B mRNA"28903501
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PARD3B mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of PARD3B mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PARD3B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PARD3B mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PARD3B mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PARD3B gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PARD3B mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PARD3B mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PARD3B mRNA21871943
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PARD3B mRNA19770486
C006780bisphenol Abisphenol A results in decreased expression of PARD3B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PARD3B gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of PARD3B mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PARD3B mRNA18974090
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PARD3B mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PARD3B mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PARD3B mRNA25270620
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of PARD3B mRNA24535843
C024565ethylene dichlorideethylene dichloride results in decreased expression of PARD3B mRNA28189721
D017313FenretinideFenretinide results in decreased expression of PARD3B mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PARD3B mRNA27392435
D008727MethotrexateMethotrexate results in increased expression of PARD3B mRNA24449571
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PARD3B mRNA"20188158
D009532NickelNickel results in decreased expression of PARD3B mRNA24768652
D010634PhenobarbitalPhenobarbital affects the expression of PARD3B mRNA23091169
D011192Potassium DichromatePotassium Dichromate results in increased expression of PARD3B mRNA23608068
D011441PropylthiouracilPropylthiouracil results in increased expression of PARD3B mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of PARD3B mRNA27029645
D012715Sesame OilSesame Oil results in increased expression of PARD3B mRNA29191790
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PARD3B mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PARD3B mRNA28922406
D013849ThimerosalThimerosal results in increased expression of PARD3B mRNA24675092
D013853ThioacetamideThioacetamide results in decreased expression of PARD3B mRNA23411599
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of PARD3B mRNA"17951470
D014520UrethaneUrethane results in increased expression of PARD3B mRNA28818685
D014638VanadatesVanadates results in decreased expression of PARD3B mRNA22714537
C025643vinclozolinvinclozolin results in increased expression of PARD3B mRNA23034163
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PARD3B mRNA"27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16458856  
GO:0035091phosphatidylinositol binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-IBA21873635  
GO:0007049cell cycle-IEA-  
GO:0007155cell adhesion-IBA21873635  
GO:0030010establishment of cell polarity-IBA21873635  
GO:0045197establishment or maintenance of epithelial cell apical/basal polarity-IBA21873635  
GO:0051301cell division-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005912adherens junction-IBA21873635  
GO:0005913cell-cell adherens junction-IBA21873635  
GO:0005923bicellular tight junction-IEA-  
GO:0005938cell cortex-IBA21873635  
GO:0012505endomembrane system-IEA-  
GO:0016020membrane-IEA-  
GO:0016324apical plasma membrane-IBA21873635  
GO:0016604nuclear body-IDA-  
GO:0030054cell junction-IDA-  
GO:0032991protein-containing complex-IDA16458856  
GO:0043296apical junction complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal