Gene: ADH4

127
ADH-2|HEL-S-4
AD dehydrogenase 4 (class II), pi polypeptide
protein-coding
4q23
Ensembl:ENSG00000198099 MIM:103740 Vega:OTTHUMG00000161227 UniprotKB:P08319
NC_000004.12
PubMed|SNP Mapped
CD|OD|ND|AD
33   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.043e-1 (AD)  3.013e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4148883chr4:99145181 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6831352chr4:99142374 (GRCh38.p7)T>A / T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6532800chr4:99137733 (GRCh38.p7)T>C / T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs6532798chr4:99133676 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6822348chr4:99132743 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1126670chr4:99131582 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs4699710chr4:99130668 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6836440chr4:99127355 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs1126671chr4:99127263 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1573495chr4:99125534 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DMBX10.823
DMP10.747
FOXI20.739
CDKN2B0.72
GALR10.716
SIX10.713
SPOCD10.705
SUCNR10.7
SAGE10.693
CHRNB40.693

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLA2G6-0.417
OGDHL-0.415
TMEM143-0.405
OMG-0.405
FUT9-0.404
DBP-0.403
EXTL1-0.398
RNFT2-0.396
ASPDH-0.391
NAT8L-0.39

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB03559CyclohexylformamideSmall MoleculeExperimentalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalEnzyme
DB00898EthanolSmall Molecule64-17-5ApprovedEnzyme
ID Drug Name Action PubMed
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of ADH4 protein22527513
C492600(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate"(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate affects the expression of ADH4 mRNA"19176366
C0158022,6-dichloro-4-nitrophenol"2,6-dichloro-4-nitrophenol inhibits the reaction [ADH4 protein results in increased metabolism of Ethanol]"19822198
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 mRNA]27055685
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 protein]27055685
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ADH4 mRNA"27055685
D000079AcetaldehydeADH4 promoter polymorphism affects the abundance of Acetaldehyde19182438
D000079AcetaldehydeADH4 protein results in increased abundance of Acetaldehyde19182438
D000082AcetaminophenAcetaminophen results in decreased expression of ADH4 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ADH4 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of ADH4 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ADH4 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ADH4 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ADH4 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ADH4 mRNA19770486
D000452AldrinAldrin results in increased expression of ADH4 mRNA18579281
D000638AmiodaroneAmiodarone affects the expression of ADH4 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ADH4 mRNA16483693
C547126AZM551248AZM551248 results in decreased expression of ADH4 mRNA22323515
D001553BenzbromaroneBenzbromarone affects the expression of ADH4 mRNA19483382
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of ADH4 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADH4 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ADH4 mRNA19770486|2012785
D004958EstradiolEstradiol results in decreased expression of ADH4 mRNA20106945
C095105bexarotenebexarotene results in increased expression of ADH4 mRNA17630414
C006780bisphenol Abisphenol A results in decreased expression of ADH4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ADH4 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ADH4 mRNA26314618
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ADH4 mRNA27339419
C022990chromic chloridechromic chloride results in decreased expression of ADH4 mRNA16690119
D002927CimetidineCimetidine inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol]23220590
D002994ClofibrateClofibrate affects the expression of ADH4 mRNA19483382
D019327Copper SulfateCopper Sulfate results in decreased expression of ADH4 mRNA19549813
D019327Copper SulfateCopper Sulfate results in increased expression of ADH4 mRNA18579281
D016572CyclosporineCyclosporine results in decreased expression of ADH4 mRNA20106945|2556210
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ADH4 mRNA28628672
C000944dicrotophosdicrotophos results in decreased expression of ADH4 mRNA28302478
D004042Dietary Fats, Unsaturated"Dietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of ADH4 mRNA]"23626681
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of ADH4 mRNA21527772
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of ADH4 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of ADH4 mRNA19638242
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of ADH4 mRNA17072980
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of ADH4 mRNA"23811387
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADH4 mRNA26159488
D004726EndosulfanEndosulfan promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 mRNA]28673560
D004726EndosulfanEndosulfan results in decreased expression of ADH4 mRNA26159488|2867356
D004726EndosulfanEndosulfan results in decreased expression of ADH4 protein28673560
D004726EndosulfanTetrachlorodibenzodioxin promotes the reaction [Endosulfan results in decreased expression of ADH4 mRNA]28673560
D000431Ethanol"2,6-dichloro-4-nitrophenol inhibits the reaction [ADH4 protein results in increased metabolism of Ethanol]"19822198
D000431EthanolADH4 promoter polymorphism affects the oxidation of Ethanol19182438
D000431EthanolADH4 protein results in increased metabolism of Ethanol19822198
D000431EthanolADH4 protein results in increased oxidation of Ethanol19182438|2116714
D000431EthanolCimetidine inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol]23220590
D000431Ethanolfomepizole inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol]21167143
D000431EthanolPentachlorophenol inhibits the reaction [ADH4 protein results in increased metabolism of Ethanol]19822198
D000431EthanolEthanol results in decreased expression of ADH4 mRNA19637192
D000431EthanolZinc inhibits the reaction [Ethanol results in decreased expression of ADH4 mRNA]19637192
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ADH4 mRNA23550701
D005001EthionineEthionine affects the expression of ADH4 mRNA19483382
D019855Ethylene GlycolADH4 protein results in increased oxidation of Ethylene Glycol21167143
C052017ethylene glycol monohexyl etherADH4 protein results in increased oxidation of ethylene glycol monohexyl ether9630456
D005026Ethylene GlycolsADH4 protein results in increased metabolism of Ethylene Glycols15551062
D011345FenofibrateFenofibrate results in decreased expression of ADH4 mRNA25572481
C082360fipronilfipronil results in increased expression of ADH4 mRNA23962444
D005485FlutamideFlutamide results in decreased expression of ADH4 mRNA24793618
C010238fomepizolefomepizole inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol]21167143
D005557FormaldehydeFormaldehyde results in increased expression of ADH4 mRNA23649840
C039281furanfuran results in increased expression of ADH4 mRNA25539665|2619464
D005839GentamicinsGentamicins results in increased expression of ADH4 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of ADH4 mRNA24136188
C010176halofuginonehalofuginone results in increased expression of ADH4 mRNA17180598
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ADH4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ADH4 mRNA28628672
D007854LeadLead results in increased expression of ADH4 mRNA19921347
D008713MethimazoleMethimazole results in decreased expression of ADH4 mRNA17403546
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of ADH4 mRNA27055685
D009285NaphthoquinonesNaphthoquinones results in increased expression of ADH4 mRNA23811387
C051752nefazodonenefazodone results in increased expression of ADH4 mRNA24136188
D009853OmeprazoleOmeprazole affects the expression of ADH4 mRNA19483382
D009966OrphenadrineOrphenadrine affects the expression of ADH4 mRNA23665939
D010416PentachlorophenolPentachlorophenol inhibits the reaction [ADH4 protein results in increased metabolism of Ethanol]19822198
C494474perchlorateperchlorate results in decreased expression of ADH4 mRNA17403546
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ADH4 mRNA19162173
C023036perfluorooctanoic acid"Dietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of ADH4 mRNA]"23626681
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ADH4 mRNA20118188|2362668
C023036perfluorooctanoic acidPPARA promotes the reaction [perfluorooctanoic acid results in increased expression of ADH4 mRNA]20118188
D010634PhenobarbitalPhenobarbital results in decreased expression of ADH4 mRNA19084549
D010634PhenobarbitalPhenobarbital affects the expression of ADH4 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of ADH4 mRNA25182419
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ADH4 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of ADH4 mRNA18445702|2381119
C006253pirinixic acidpirinixic acid results in increased expression of ADH4 mRNA17426115
C006253pirinixic acidpirinixic acid affects the expression of ADH4 mRNA19483382
C006253pirinixic acidpirinixic acid results in increased expression of ADH4 mRNA19162173
D011192Potassium DichromatePotassium Dichromate results in increased expression of ADH4 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of ADH4 mRNA28903501
C045362prochlorazprochloraz results in increased expression of ADH4 mRNA25182419
C035988procymidoneprocymidone results in increased expression of ADH4 mRNA15686871
D0198402-PropanolADH4 protein results in increased oxidation of 2-Propanol21167143
C045950propiconazolepropiconazole results in decreased expression of ADH4 mRNA19363144|2127805
D011441PropylthiouracilPropylthiouracil affects the expression of ADH4 mRNA19483382
D011441PropylthiouracilPropylthiouracil results in decreased expression of ADH4 mRNA17403546
C031280pyrazolepyrazole results in decreased activity of ADH4 protein15551062
D011794QuercetinQuercetin results in decreased expression of ADH4 mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of ADH4 mRNA21632981
D012172RetinaldehydeADH4 protein results in increased metabolism of Retinaldehyde17279314
D012172RetinaldehydeADH4 protein results in increased chemical synthesis of Retinaldehyde17473173
C089730rosiglitazonerosiglitazone results in decreased expression of ADH4 mRNA25572481
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ADH4 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ADH4 mRNA23221170
C016104sodium bichromatesodium bichromate results in increased expression of ADH4 mRNA25993096
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ADH4 mRNA"18579281
D013749Tetrachlorodibenzodioxin2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 mRNA]27055685
D013749Tetrachlorodibenzodioxin2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 protein]27055685
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 mRNA]27055685
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 protein]27055685
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 mRNA]27055685
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 protein]27055685
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADH4 mRNA26159488
D013749TetrachlorodibenzodioxinEndosulfan promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 mRNA]28673560
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [Endosulfan results in decreased expression of ADH4 mRNA]28673560
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADH4 mRNA11489354|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADH4 protein27055685|2867356
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADH4 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADH4 mRNA26290441|2705568
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADH4 mRNA21724226
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ADH4 mRNA21215274
D013853ThioacetamideThioacetamide affects the expression of ADH4 mRNA19483382
D013853ThioacetamideThioacetamide results in increased expression of ADH4 mRNA23411599
D014212TretinoinADH4 protein mutant form results in increased metabolism of Tretinoin17279314
C032910triadimefontriadimefon results in decreased expression of ADH4 mRNA19363144
D014241TrichloroethyleneTrichloroethylene results in increased expression of ADH4 mRNA19448997
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ADH4 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of ADH4 mRNA25572481
D014520UrethaneUrethane results in decreased expression of ADH4 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of ADH4 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of ADH4 mRNA17292431
D014752Vinyl ChlorideVinyl Chloride results in increased expression of ADH4 mRNA18579281
D014801Vitamin AADH4 protein results in increased oxidation of Vitamin A17473173
D015032ZincZinc inhibits the reaction [Ethanol results in decreased expression of ADH4 mRNA]19637192

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003960NADPH:quinone reductase activity-ISS-  
GO:0004022alcohol dehydrogenase (NAD) activity-IDA3466164  16787387  
GO:0004024alcohol dehydrogenase activity, zinc-dependent-EXP9982  
GO:0004024alcohol dehydrogenase activity, zinc-dependent-IDA10407146  
GO:0004032alditol:NADP+ 1-oxidoreductase activity-IEA-  
GO:0004745retinol dehydrogenase activity-IDA15369820  16787387  
GO:0004745retinol dehydrogenase activity-TAS-  
GO:0005503all-trans retinal binding-IDA15369820  
GO:0008270zinc ion binding-IDA10407146  
GO:0016620oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor-IDA3466164  
GO:0019115benzaldehyde dehydrogenase activity-IDA3466164  
GO:0019841retinol binding-IDA10407146  
GO:0035276ethanol binding-IEA-  
GO:0051287NAD binding-IDA10407146  
GO ID GO Term Qualifier Evidence PubMed
GO:0001523retinoid metabolic process-IDA15369820  
GO:0006066alcohol metabolic process-IDA3466164  
GO:0006069ethanol oxidation-IDA16787387  
GO:0006069ethanol oxidation-TAS-  
GO:0006081cellular aldehyde metabolic process-IDA3466164  
GO:0042572retinol metabolic process-IDA16787387  
GO:0046164alcohol catabolic process-ISS-  
GO:1901661quinone metabolic process-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00071Fatty acid degradation
hsa00350Tyrosine metabolism
hsa00830Retinol metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-5362517Signaling by Retinoic AcidTAS
R-HSA-5365859RA biosynthesis pathwayTAS
R-HSA-71384Ethanol oxidationTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21083667Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. (2011 Feb)Liu JAlcohol Clin Exp Res
1362387Alcohol dehydrogenase genes: restriction fragment length polymorphisms for ADH4 (pi-ADH) and ADH5 (chi-ADH) and construction of haplotypes among different ADH classes. (1992 Dec)Edman KHum Genet
24692236Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders. (2014 Jun)Kos MZAm J Med Genet B Neuropsychiatr Genet
23019235Rare ADH variant constellations are specific for alcohol dependence. (2013 Jan-Feb)Zuo LAlcohol Alcohol
22232963[Research on associations between selected polymorphisms of genes DRD2, 5HTT, GRIK3, ADH4 and alcohol dependence syndrome]. (2011 May-Jun)Grochans EPsychiatr Pol
16961766The genetics of alcoholism: identifying specific genes through family studies. (2006 Sep)Edenberg HJAddict Biol
6356165Hepatic ADH and ALDH isoenzymes in different racial groups and in chronic alcoholism. (1983)Ricciardi BRPharmacol Biochem Behav
19861527Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population. (2009 Nov)Oze ICancer Epidemiol Biomarkers Prev
19193628ADH single nucleotide polymorphism associations with alcohol metabolism in vivo. (2009 Apr 15)Birley AJHum Mol Genet
18801187Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test. (2008 Sep 18)Luo XBehav Brain Funct
26039424Impact of alcohol dehydrogenase gene 4 polymorphisms on esophageal squamous cell carcinoma risk in a Chinese population. (2015)Xu XPLoS One
21635275Association of alcohol dehydrogenase genes with alcohol-related phenotypes in a Native American community sample. (2011 Nov)Gizer IRAlcohol Clin Exp Res
19182438Polymorphisms in the promoter region of the human class II alcohol dehydrogenase (ADH4) gene affect both transcriptional activity and ethanol metabolism in Japanese subjects. (2009 Feb)Kimura YJ Toxicol Sci
16571603Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis. (2006 May 1)Edenberg HJHum Mol Genet
27172571Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms. (2016 May)Chartier KGJ Stud Alcohol Drugs
26230553[Alcohol consumption patterns and genotypes determining alcohol tolerance in Chilean university students]. (2015 Jun)Silva CPRev Med Chil
15863808Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients. (2005 May)Guindalini CAm J Psychiatry
18996923Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. (2009 Feb 1)Macgregor SHum Mol Genet
22044940ADH4 intronic variations are associated with alcohol dependence: results from an Italian case-control association study. (2012 Feb)Turchi CPharmacogenet Genomics
28815635Associations Between Genomic Variants in Alcohol Dehydrogenase Genes and Alcohol Symptomatology in American Indians and European Americans: Distinctions and Convergence. (2017 Oct)Peng QAlcohol Clin Exp Res
23504072Association of VMAT2 gene polymorphisms with alcohol dependence. (2013 Aug)Fehr CJ Neural Transm (Vienna)
10208639Polymorphism of the human alcohol dehydrogenase 4 (ADH4) promoter affects gene expression. (1999 Feb)Edenberg HJPharmacogenetics
20626721Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study. (2011 Apr)Preuss UWAddict Biol
18331377Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. (2008 May)Kuo PHAlcohol Clin Exp Res
20363298Identification of a FOXA-dependent enhancer of human alcohol dehydrogenase 4 (ADH4). (2010 Jul 15)Pochareddy SGene
23468174Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism. (2013 Jul)Zuo LHum Genet
28805974Effect of single-nucleotide polymorphisms in ADH1B, ADH4, ADH1C, OPRM1, DRD2, BDNF, and ALDH2 genes on alcohol dependence in a Caucasian population. (2017 Aug)Katsarou MSPharmacol Res Perspect
24889829Identification of methylation quantitative trait loci (mQTLs) influencing promoter DNA methylation of alcohol dependence risk genes. (2014 Sep)Zhang HHum Genet
16237392ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies. (2006 May)Luo XNeuropsychopharmacology
16220108ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies. (2005 Nov)Luo XPharmacogenet Genomics
23456092Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. (2013 Jun)Park BLHum Genet
18242813Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. (2008 Mar 12)Kollock RToxicology
29084628First description and evaluation of SNPs in the ADH and ALDH genes in a population of alcoholics in Central-West Brazil. (2017 Dec)Teixeira TMAlcohol