Gene info: ID 127

Gene: ADH4

GENE ID: 127

Synonyms: ADH-2|HEL-S-4

Description: AD dehydrogenase 4 (class II), pi polypeptide

Gene type: protein-coding

Location: 4q23

dbXrefs: Ensembl:ENSG00000198099 MIM:103740 Vega:OTTHUMG00000161227 UniprotKB:P08319

RefSeq: NC_000004.12

Retrived from: PubMed|SNP Mapped

SNPs: 10 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 33

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.043e-1 (AD) 3.013e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs4148883	chr4:99145181 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs6831352	chr4:99142374 (GRCh38.p7)	T>A / T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs6532800	chr4:99137733 (GRCh38.p7)	T>C / T>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs6532798	chr4:99133676 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs6822348	chr4:99132743 (GRCh38.p7)	A>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs1126670	chr4:99131582 (GRCh38.p7)	C>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs4699710	chr4:99130668 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs6836440	chr4:99127355 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs1126671	chr4:99127263 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs1573495	chr4:99125534 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DMBX1	0.823
DMP1	0.747
FOXI2	0.739
CDKN2B	0.72
GALR1	0.716
SIX1	0.713
SPOCD1	0.705
SUCNR1	0.7
SAGE1	0.693
CHRNB4	0.693

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PLA2G6	-0.417
OGDHL	-0.415
TMEM143	-0.405
OMG	-0.405
FUT9	-0.404
DBP	-0.403
EXTL1	-0.398
RNFT2	-0.396
ASPDH	-0.391
NAT8L	-0.39

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00157	NADH	Small Molecule	58-68-4	Approved\|Nutraceutical	Target
DB03559	Cyclohexylformamide	Small Molecule		Experimental	Target
DB00157	NADH	Small Molecule	58-68-4	Approved\|Nutraceutical	Enzyme
DB00898	Ethanol	Small Molecule	64-17-5	Approved	Enzyme

ID	Drug Name	Action	PubMed
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of ADH4 protein	22527513
C492600	(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate	"(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate affects the expression of ADH4 mRNA"	19176366
C015802	2,6-dichloro-4-nitrophenol	"2,6-dichloro-4-nitrophenol inhibits the reaction [ADH4 protein results in increased metabolism of Ethanol]"	19822198
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 mRNA]	27055685
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 protein]	27055685
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ADH4 mRNA"	27055685
D000079	Acetaldehyde	ADH4 promoter polymorphism affects the abundance of Acetaldehyde	19182438
D000079	Acetaldehyde	ADH4 protein results in increased abundance of Acetaldehyde	19182438
D000082	Acetaminophen	Acetaminophen results in decreased expression of ADH4 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of ADH4 mRNA	17562736
D020106	Acrylamide	Acrylamide results in decreased expression of ADH4 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of ADH4 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of ADH4 mRNA	22100608\|2715375
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of ADH4 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of ADH4 mRNA	19770486
D000452	Aldrin	Aldrin results in increased expression of ADH4 mRNA	18579281
D000638	Amiodarone	Amiodarone affects the expression of ADH4 mRNA	19483382
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ADH4 mRNA	16483693
C547126	AZM551248	AZM551248 results in decreased expression of ADH4 mRNA	22323515
D001553	Benzbromarone	Benzbromarone affects the expression of ADH4 mRNA	19483382
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of ADH4 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ADH4 mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ADH4 mRNA	19770486\|2012785
D004958	Estradiol	Estradiol results in decreased expression of ADH4 mRNA	20106945
C095105	bexarotene	bexarotene results in increased expression of ADH4 mRNA	17630414
C006780	bisphenol A	bisphenol A results in decreased expression of ADH4 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of ADH4 gene	28505145
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of ADH4 mRNA	26314618
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of ADH4 mRNA	27339419
C022990	chromic chloride	chromic chloride results in decreased expression of ADH4 mRNA	16690119
D002927	Cimetidine	Cimetidine inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol]	23220590
D002994	Clofibrate	Clofibrate affects the expression of ADH4 mRNA	19483382
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of ADH4 mRNA	19549813
D019327	Copper Sulfate	Copper Sulfate results in increased expression of ADH4 mRNA	18579281
D016572	Cyclosporine	Cyclosporine results in decreased expression of ADH4 mRNA	20106945\|2556210
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ADH4 mRNA	28628672
C000944	dicrotophos	dicrotophos results in decreased expression of ADH4 mRNA	28302478
D004042	Dietary Fats, Unsaturated	"Dietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of ADH4 mRNA]"	23626681
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of ADH4 mRNA	21527772
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of ADH4 mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of ADH4 mRNA	19638242
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of ADH4 mRNA	17072980
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of ADH4 mRNA"	23811387
D004726	Endosulfan	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADH4 mRNA	26159488
D004726	Endosulfan	Endosulfan promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 mRNA]	28673560
D004726	Endosulfan	Endosulfan results in decreased expression of ADH4 mRNA	26159488\|2867356
D004726	Endosulfan	Endosulfan results in decreased expression of ADH4 protein	28673560
D004726	Endosulfan	Tetrachlorodibenzodioxin promotes the reaction [Endosulfan results in decreased expression of ADH4 mRNA]	28673560
D000431	Ethanol	"2,6-dichloro-4-nitrophenol inhibits the reaction [ADH4 protein results in increased metabolism of Ethanol]"	19822198
D000431	Ethanol	ADH4 promoter polymorphism affects the oxidation of Ethanol	19182438
D000431	Ethanol	ADH4 protein results in increased metabolism of Ethanol	19822198
D000431	Ethanol	ADH4 protein results in increased oxidation of Ethanol	19182438\|2116714
D000431	Ethanol	Cimetidine inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol]	23220590
D000431	Ethanol	fomepizole inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol]	21167143
D000431	Ethanol	Pentachlorophenol inhibits the reaction [ADH4 protein results in increased metabolism of Ethanol]	19822198
D000431	Ethanol	Ethanol results in decreased expression of ADH4 mRNA	19637192
D000431	Ethanol	Zinc inhibits the reaction [Ethanol results in decreased expression of ADH4 mRNA]	19637192
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of ADH4 mRNA	23550701
D005001	Ethionine	Ethionine affects the expression of ADH4 mRNA	19483382
D019855	Ethylene Glycol	ADH4 protein results in increased oxidation of Ethylene Glycol	21167143
C052017	ethylene glycol monohexyl ether	ADH4 protein results in increased oxidation of ethylene glycol monohexyl ether	9630456
D005026	Ethylene Glycols	ADH4 protein results in increased metabolism of Ethylene Glycols	15551062
D011345	Fenofibrate	Fenofibrate results in decreased expression of ADH4 mRNA	25572481
C082360	fipronil	fipronil results in increased expression of ADH4 mRNA	23962444
D005485	Flutamide	Flutamide results in decreased expression of ADH4 mRNA	24793618
C010238	fomepizole	fomepizole inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol]	21167143
D005557	Formaldehyde	Formaldehyde results in increased expression of ADH4 mRNA	23649840
C039281	furan	furan results in increased expression of ADH4 mRNA	25539665\|2619464
D005839	Gentamicins	Gentamicins results in increased expression of ADH4 mRNA	22061828
D005897	Glafenine	Glafenine results in decreased expression of ADH4 mRNA	24136188
C010176	halofuginone	halofuginone results in increased expression of ADH4 mRNA	17180598
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ADH4 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ADH4 mRNA	28628672
D007854	Lead	Lead results in increased expression of ADH4 mRNA	19921347
D008713	Methimazole	Methimazole results in decreased expression of ADH4 mRNA	17403546
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of ADH4 mRNA	27055685
D009285	Naphthoquinones	Naphthoquinones results in increased expression of ADH4 mRNA	23811387
C051752	nefazodone	nefazodone results in increased expression of ADH4 mRNA	24136188
D009853	Omeprazole	Omeprazole affects the expression of ADH4 mRNA	19483382
D009966	Orphenadrine	Orphenadrine affects the expression of ADH4 mRNA	23665939
D010416	Pentachlorophenol	Pentachlorophenol inhibits the reaction [ADH4 protein results in increased metabolism of Ethanol]	19822198
C494474	perchlorate	perchlorate results in decreased expression of ADH4 mRNA	17403546
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of ADH4 mRNA	19162173
C023036	perfluorooctanoic acid	"Dietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of ADH4 mRNA]"	23626681
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of ADH4 mRNA	20118188\|2362668
C023036	perfluorooctanoic acid	PPARA promotes the reaction [perfluorooctanoic acid results in increased expression of ADH4 mRNA]	20118188
D010634	Phenobarbital	Phenobarbital results in decreased expression of ADH4 mRNA	19084549
D010634	Phenobarbital	Phenobarbital affects the expression of ADH4 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of ADH4 mRNA	25182419
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ADH4 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of ADH4 mRNA	18445702\|2381119
C006253	pirinixic acid	pirinixic acid results in increased expression of ADH4 mRNA	17426115
C006253	pirinixic acid	pirinixic acid affects the expression of ADH4 mRNA	19483382
C006253	pirinixic acid	pirinixic acid results in increased expression of ADH4 mRNA	19162173
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of ADH4 mRNA	23608068
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of ADH4 mRNA	28903501
C045362	prochloraz	prochloraz results in increased expression of ADH4 mRNA	25182419
C035988	procymidone	procymidone results in increased expression of ADH4 mRNA	15686871
D019840	2-Propanol	ADH4 protein results in increased oxidation of 2-Propanol	21167143
C045950	propiconazole	propiconazole results in decreased expression of ADH4 mRNA	19363144\|2127805
D011441	Propylthiouracil	Propylthiouracil affects the expression of ADH4 mRNA	19483382
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of ADH4 mRNA	17403546
C031280	pyrazole	pyrazole results in decreased activity of ADH4 protein	15551062
D011794	Quercetin	Quercetin results in decreased expression of ADH4 mRNA	21632981
D015125	Oxyquinoline	Oxyquinoline results in decreased expression of ADH4 mRNA	21632981
D012172	Retinaldehyde	ADH4 protein results in increased metabolism of Retinaldehyde	17279314
D012172	Retinaldehyde	ADH4 protein results in increased chemical synthesis of Retinaldehyde	17473173
C089730	rosiglitazone	rosiglitazone results in decreased expression of ADH4 mRNA	25572481
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of ADH4 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of ADH4 mRNA	23221170
C016104	sodium bichromate	sodium bichromate results in increased expression of ADH4 mRNA	25993096
D015085	2,4,5-Trichlorophenoxyacetic Acid	"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ADH4 mRNA"	18579281
D013749	Tetrachlorodibenzodioxin	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 mRNA]	27055685
D013749	Tetrachlorodibenzodioxin	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 protein]	27055685
D013749	Tetrachlorodibenzodioxin	AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 mRNA]	27055685
D013749	Tetrachlorodibenzodioxin	AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 protein]	27055685
D013749	Tetrachlorodibenzodioxin	ARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 mRNA]	27055685
D013749	Tetrachlorodibenzodioxin	ARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 protein]	27055685
D013749	Tetrachlorodibenzodioxin	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADH4 mRNA	26159488
D013749	Tetrachlorodibenzodioxin	Endosulfan promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH4 mRNA]	28673560
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [Endosulfan results in decreased expression of ADH4 mRNA]	28673560
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ADH4 mRNA	11489354\|2010694
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ADH4 protein	27055685\|2867356
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ADH4 mRNA	26377647
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ADH4 mRNA	26290441\|2705568
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ADH4 mRNA	21724226
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ADH4 mRNA	21215274
D013853	Thioacetamide	Thioacetamide affects the expression of ADH4 mRNA	19483382
D013853	Thioacetamide	Thioacetamide results in increased expression of ADH4 mRNA	23411599
D014212	Tretinoin	ADH4 protein mutant form results in increased metabolism of Tretinoin	17279314
C032910	triadimefon	triadimefon results in decreased expression of ADH4 mRNA	19363144
D014241	Trichloroethylene	Trichloroethylene results in increased expression of ADH4 mRNA	19448997
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ADH4 mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of ADH4 mRNA	25572481
D014520	Urethane	Urethane results in decreased expression of ADH4 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of ADH4 mRNA	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of ADH4 mRNA	17292431
D014752	Vinyl Chloride	Vinyl Chloride results in increased expression of ADH4 mRNA	18579281
D014801	Vitamin A	ADH4 protein results in increased oxidation of Vitamin A	17473173
D015032	Zinc	Zinc inhibits the reaction [Ethanol results in decreased expression of ADH4 mRNA]	19637192

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003960	NADPH:quinone reductase activity	-	ISS	-
GO:0004022	alcohol dehydrogenase (NAD) activity	-	IDA	3466164 16787387
GO:0004024	alcohol dehydrogenase activity, zinc-dependent	-	EXP	9982
GO:0004024	alcohol dehydrogenase activity, zinc-dependent	-	IDA	10407146
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	-	IEA	-
GO:0004745	retinol dehydrogenase activity	-	IDA	15369820 16787387
GO:0004745	retinol dehydrogenase activity	-	TAS	-
GO:0005503	all-trans retinal binding	-	IDA	15369820
GO:0008270	zinc ion binding	-	IDA	10407146
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	-	IDA	3466164
GO:0019115	benzaldehyde dehydrogenase activity	-	IDA	3466164
GO:0019841	retinol binding	-	IDA	10407146
GO:0035276	ethanol binding	-	IEA	-
GO:0051287	NAD binding	-	IDA	10407146

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001523	retinoid metabolic process	-	IDA	15369820
GO:0006066	alcohol metabolic process	-	IDA	3466164
GO:0006069	ethanol oxidation	-	IDA	16787387
GO:0006069	ethanol oxidation	-	TAS	-
GO:0006081	cellular aldehyde metabolic process	-	IDA	3466164
GO:0042572	retinol metabolic process	-	IDA	16787387
GO:0046164	alcohol catabolic process	-	ISS	-
GO:1901661	quinone metabolic process	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	-
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term
hsa00010	Glycolysis / Gluconeogenesis
hsa00071	Fatty acid degradation
hsa00350	Tyrosine metabolism
hsa00830	Retinol metabolism
hsa00980	Metabolism of xenobiotics by cytochrome P450
hsa00982	Drug metabolism - cytochrome P450
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-211859	Biological oxidations	TAS
R-HSA-211945	Phase I - Functionalization of compounds	TAS
R-HSA-5362517	Signaling by Retinoic Acid	TAS
R-HSA-5365859	RA biosynthesis pathway	TAS
R-HSA-71384	Ethanol oxidation	TAS
R-HSA-9006931	Signaling by Nuclear Receptors	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21083667	Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. (2011 Feb)	Liu J	Alcohol Clin Exp Res
1362387	Alcohol dehydrogenase genes: restriction fragment length polymorphisms for ADH4 (pi-ADH) and ADH5 (chi-ADH) and construction of haplotypes among different ADH classes. (1992 Dec)	Edman K	Hum Genet
24692236	Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders. (2014 Jun)	Kos MZ	Am J Med Genet B Neuropsychiatr Genet
23019235	Rare ADH variant constellations are specific for alcohol dependence. (2013 Jan-Feb)	Zuo L	Alcohol Alcohol
22232963	[Research on associations between selected polymorphisms of genes DRD2, 5HTT, GRIK3, ADH4 and alcohol dependence syndrome]. (2011 May-Jun)	Grochans E	Psychiatr Pol
16961766	The genetics of alcoholism: identifying specific genes through family studies. (2006 Sep)	Edenberg HJ	Addict Biol
6356165	Hepatic ADH and ALDH isoenzymes in different racial groups and in chronic alcoholism. (1983)	Ricciardi BR	Pharmacol Biochem Behav
19861527	Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population. (2009 Nov)	Oze I	Cancer Epidemiol Biomarkers Prev
19193628	ADH single nucleotide polymorphism associations with alcohol metabolism in vivo. (2009 Apr 15)	Birley AJ	Hum Mol Genet
18801187	Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test. (2008 Sep 18)	Luo X	Behav Brain Funct
26039424	Impact of alcohol dehydrogenase gene 4 polymorphisms on esophageal squamous cell carcinoma risk in a Chinese population. (2015)	Xu X	PLoS One
21635275	Association of alcohol dehydrogenase genes with alcohol-related phenotypes in a Native American community sample. (2011 Nov)	Gizer IR	Alcohol Clin Exp Res
19182438	Polymorphisms in the promoter region of the human class II alcohol dehydrogenase (ADH4) gene affect both transcriptional activity and ethanol metabolism in Japanese subjects. (2009 Feb)	Kimura Y	J Toxicol Sci
16571603	Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis. (2006 May 1)	Edenberg HJ	Hum Mol Genet
27172571	Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms. (2016 May)	Chartier KG	J Stud Alcohol Drugs
26230553	[Alcohol consumption patterns and genotypes determining alcohol tolerance in Chilean university students]. (2015 Jun)	Silva CP	Rev Med Chil
15863808	Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients. (2005 May)	Guindalini C	Am J Psychiatry
18996923	Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. (2009 Feb 1)	Macgregor S	Hum Mol Genet
22044940	ADH4 intronic variations are associated with alcohol dependence: results from an Italian case-control association study. (2012 Feb)	Turchi C	Pharmacogenet Genomics
28815635	Associations Between Genomic Variants in Alcohol Dehydrogenase Genes and Alcohol Symptomatology in American Indians and European Americans: Distinctions and Convergence. (2017 Oct)	Peng Q	Alcohol Clin Exp Res
23504072	Association of VMAT2 gene polymorphisms with alcohol dependence. (2013 Aug)	Fehr C	J Neural Transm (Vienna)
10208639	Polymorphism of the human alcohol dehydrogenase 4 (ADH4) promoter affects gene expression. (1999 Feb)	Edenberg HJ	Pharmacogenetics
20626721	Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study. (2011 Apr)	Preuss UW	Addict Biol
18331377	Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. (2008 May)	Kuo PH	Alcohol Clin Exp Res
20363298	Identification of a FOXA-dependent enhancer of human alcohol dehydrogenase 4 (ADH4). (2010 Jul 15)	Pochareddy S	Gene
23468174	Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism. (2013 Jul)	Zuo L	Hum Genet
28805974	Effect of single-nucleotide polymorphisms in ADH1B, ADH4, ADH1C, OPRM1, DRD2, BDNF, and ALDH2 genes on alcohol dependence in a Caucasian population. (2017 Aug)	Katsarou MS	Pharmacol Res Perspect
24889829	Identification of methylation quantitative trait loci (mQTLs) influencing promoter DNA methylation of alcohol dependence risk genes. (2014 Sep)	Zhang H	Hum Genet
16237392	ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies. (2006 May)	Luo X	Neuropsychopharmacology
16220108	ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies. (2005 Nov)	Luo X	Pharmacogenet Genomics
23456092	Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. (2013 Jun)	Park BL	Hum Genet
18242813	Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. (2008 Mar 12)	Kollock R	Toxicology
29084628	First description and evaluation of SNPs in the ADH and ALDH genes in a population of alcoholics in Central-West Brazil. (2017 Dec)	Teixeira TM	Alcohol