Gene: ZNF786

136051
-
zinc finger protein 786
protein-coding
7q36.1
Ensembl:ENSG00000197362 Vega:OTTHUMG00000158975 UniprotKB:Q8N393
NC_000007.14
SNP Mapped
3   ANCO-SNPs
AD
0   
4.316e-1 (AD)  8.833e-1 (ND)   (Frontal_Cortex)
9.046e-1 (AD)  2.259e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7797617chr7:149088629 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs12113550chr7:149081590 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs6973937chr7:149074254 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAPK130.895
ATG16L10.894
LMTK20.89
UBE2O0.89
PRDM20.889
UNC790.888
SMPD30.888
MYH100.887
TLN20.887
CDK200.886

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.52
YES1-0.517
MYL3-0.514
HEY2-0.501
SNHG18-0.49
RAB13-0.485
CSAG1-0.472
ASB4-0.472
MBNL3-0.459
ROM1-0.453

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0127962-butenal2-butenal results in decreased expression of ZNF786 mRNA20471460
C584509C646 compoundC646 compound results in increased expression of ZNF786 mRNA26191083
D019327Copper SulfateCopper Sulfate results in decreased expression of ZNF786 mRNA19549813
D005557FormaldehydeFormaldehyde results in decreased expression of ZNF786 mRNA20655997
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ZNF786 mRNA21179406
C492448ICG 001ICG 001 results in increased expression of ZNF786 mRNA26191083
D007854LeadLead results in increased expression of ZNF786 mRNA19921347
D014635Valproic AcidValproic Acid affects the expression of ZNF786 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ZNF786 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of ZNF786 gene28853863
D014635Valproic AcidValproic Acid results in increased methylation of ZNF786 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal