Gene: DAB1

1600
SCA37
DAB1, reelin adaptor protein
protein-coding
1p32.2
Ensembl:ENSG00000173406 MIM:603448 Vega:OTTHUMG00000008391 UniprotKB:O75553
NG_046914.2
SNP Mapped
8   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.492e-1 (AD)  2.563e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7544843chr1:57798095 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7554147chr1:57791915 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1323838chr1:57791578 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs35738462chr1:57790872 (GRCh38.p7)T>A / T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs12568292chr1:57790519 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs12565523chr1:57790476 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs12130571chr1:57232328 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs17115341chr1:57200259 (GRCh38.p7)C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNMB20.798
SDK10.783
CNR10.777
TOX30.776
CUX20.763
STXBP60.762
PIP5K1B0.759
PCDH190.759
GRIA40.758
CA100.748

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIF19-0.436
OR4F5-0.412
ZFP57-0.398
FXYD4-0.39
NKX6-2-0.379
SNHG18-0.376
TGFB3-0.368
CTNNA3-0.365
GPIHBP1-0.36
LAYN-0.359

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DAB1 mRNA"25510870
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of DAB1 mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DAB1 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DAB1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DAB1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DAB1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DAB1 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAB1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of DAB1 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of DAB1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DAB1 mRNA23630614
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DAB1 mRNA23735875
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DAB1 mRNA20127859
D004958EstradiolEstradiol affects the expression of DAB1 mRNA22574217
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in decreased expression of DAB1 mRNA25270620
C006780bisphenol Abisphenol A results in decreased expression of DAB1 mRNA25181051
D019328Buthionine SulfoximineButhionine Sulfoximine results in decreased expression of DAB1 mRNA15878706
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAB1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of DAB1 mRNA26272509
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of DAB1 mRNA28472532
D003024ClozapineClozapine results in increased expression of DAB1 mRNA19359144
D003471CuprizoneCuprizone results in decreased expression of DAB1 mRNA26577399
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of DAB1 mRNA23914054
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DAB1 mRNA17361019|2126653
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of DAB1 mRNA28962523
D004041Dietary FatsDietary Fats results in increased expression of DAB1 mRNA25016146
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of DAB1 mRNA24535843
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DAB1 mRNA26159488
D005473FluoxetineFluoxetine results in increased expression of DAB1 protein19359144
D004397FonofosFonofos results in increased methylation of DAB1 promoter22847954
C039281furanfuran results in decreased expression of DAB1 mRNA25539665
C000625835HFPO2 compoundHFPO2 compound results in increased expression of DAB1 mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in increased expression of DAB1 mRNA27553808
C016517indole-3-carbinolindole-3-carbinol affects the expression of DAB1 mRNA21396975
C042720mercuric bromidemercuric bromide results in decreased expression of DAB1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAB1 mRNA"27188386
D008628MercuryMercury results in increased expression of DAB1 mRNA16823088
C029938nickel sulfatenickel sulfate results in increased expression of DAB1 mRNA16780908
D009569Nitric OxideNitric Oxide deficiency results in decreased expression of DAB1 mRNA15878706
C076029olanzapineolanzapine results in decreased expression of DAB1 protein19359144
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAB1 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of DAB1 mRNA26272509
D010278ParathionParathion results in increased methylation of DAB1 promoter22847954
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DAB1 mRNA"25510870
C046012pentanalpentanal results in increased expression of DAB1 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAB1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of DAB1 mRNA26272509
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of DAB1 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of DAB1 mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of DAB1 mRNA18301758|2081375
D010936Plant ExtractsPlant Extracts results in decreased expression of DAB1 mRNA23557933
D010936Plant ExtractsPlant Extracts results in increased expression of DAB1 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of DAB1 mRNA22238285
C089730rosiglitazonerosiglitazone results in decreased expression of DAB1 mRNA21515302
C017947sodium arsenitesodium arsenite results in decreased expression of DAB1 mRNA25493608
D012969Sodium FluorideSodium Fluoride results in decreased expression of DAB1 mRNA27257137
C012568terbufosterbufos results in increased methylation of DAB1 promoter22847954
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DAB1 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DAB1 mRNA25975270
D013853ThioacetamideThioacetamide results in decreased expression of DAB1 mRNA23411599
D014212TretinoinTretinoin results in decreased expression of DAB1 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAB1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of DAB1 mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of DAB1 mRNA21515302
D014635Valproic AcidValproic Acid results in decreased expression of DAB1 mRNA24383497|2493525
D014635Valproic AcidValproic Acid affects the expression of DAB1 mRNA17292431|1796380
D014635Valproic AcidValproic Acid results in decreased expression of DAB1 protein19359144
D014635Valproic AcidValproic Acid results in increased expression of DAB1 mRNA19359144
D002762CholecalciferolCholecalciferol results in increased expression of DAB1 mRNA17170073

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0043548phosphatidylinositol 3-kinase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007162negative regulation of cell adhesion-IEA-  
GO:0007264small GTPase mediated signal transduction-IEA-  
GO:0007411axon guidance-TAS-  
GO:0007494midgut development-IEA-  
GO:0007628adult walking behavior-IEA-  
GO:0016358dendrite development-IEA-  
GO:0021517ventral spinal cord development-IEA-  
GO:0021589cerebellum structural organization-IEA-  
GO:0021813cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration-IEA-  
GO:0021942radial glia guided migration of Purkinje cell-IEA-  
GO:0042493response to drug-IEA-  
GO:0045666positive regulation of neuron differentiation-IEA-  
GO:0045860positive regulation of protein kinase activity-IEA-  
GO:0046426negative regulation of JAK-STAT cascade-IEA-  
GO:0048712negative regulation of astrocyte differentiation-IEA-  
GO:0050771negative regulation of axonogenesis-IEA-  
GO:0051645Golgi localization-IEA-  
GO:0097477lateral motor column neuron migration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005903brush border-IEA-  
GO:0014069postsynaptic density-IEA-  
GO:0016020membrane-IEA-  
GO:0043005neuron projection-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0045177apical part of cell-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-422475Axon guidanceTAS
R-HSA-8866376Reelin signalling pathwayTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal