Gene info: ID 1644

Gene: DDC

GENE ID: 1644

Synonyms: AADC

Description: dopa decarboxylase

Gene type: protein-coding

Location: 7p12.2-p12.1

dbXrefs: Ensembl:ENSG00000132437 MIM:107930 Vega:OTTHUMG00000023353 UniprotKB:P20711

RefSeq: NG_008742.1

Retrived from: PubMed|SNP Mapped

SNPs: 11 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 15

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.506e-3 (AD) 5.452e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs921451	chr7:50555587 (GRCh38.p7)	T>C	nicotine dependence	SNV(Single Nucleotide Variation)
rs930707	chr7:50551980 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs11575302	chr7:50539996 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs3735273	chr7:50529166 (GRCh38.p7)	C>T	nicotine dependence	SNV(Single Nucleotide Variation)
rs11575340	chr7:50528773 (GRCh38.p7)	G>A / G>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs1451371	chr7:50485353 (GRCh38.p7)	T>C	nicotine dependence	SNV(Single Nucleotide Variation)
rs11575522	chr7:50467697 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs11575537	chr7:50464187 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs11575542	chr7:50463289 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs11575543	chr7:50463171 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs11575549	chr7:50462479 (GRCh38.p7)	C>A / C>G / C>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ISL1	0.937
SLC5A7	0.929
LHX8	0.913
SLC18A3	0.902
DGKK	0.894
SLITRK6	0.893
ANKRD34B	0.879
EBF2	0.839
SLC35D3	0.838
PRLR	0.833

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SLC17A7	-0.453
SYTL2	-0.393
NEUROD2	-0.382
TNNT2	-0.38
SOHLH1	-0.368
NXPH3	-0.345
TESPA1	-0.343
TBR1	-0.33
EMX1	-0.325
RNF182	-0.322

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00114	Pyridoxal Phosphate	Small Molecule	54-47-7	Approved\|Investigational\|Nutraceutical	Target
DB00190	Carbidopa	Small Molecule	28860-95-9	Approved	Target
DB00968	Methyldopa	Small Molecule	555-30-6	Approved	Target
DB05307	CHF-1512	Small Molecule	-	Investigational	Target
DB00114	Pyridoxal Phosphate	Small Molecule	54-47-7	Approved\|Investigational\|Nutraceutical	Target
DB00150	L-Tryptophan	Small Molecule	73-22-3	Approved\|Nutraceutical\|Withdrawn	Enzyme
DB00260	Cycloserine	Small Molecule	68-41-7	Approved	Enzyme
DB00875	Flupentixol	Small Molecule	2709-56-0	Approved\|Investigational\|Withdrawn	Enzyme
DB00915	Amantadine	Small Molecule	768-94-5	Approved	Enzyme
DB01235	Levodopa	Small Molecule	59-92-7	Approved	Enzyme
DB06262	Droxidopa	Small Molecule	23651-95-8	Approved\|Investigational	Enzyme

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of DDC mRNA	19933214
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of DDC mRNA"	21920950
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DDC mRNA"	19114083
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of DDC mRNA"	21346803
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of DDC protein"	2243617
C017821	2-amino-3-methyl-9H-pyrido(2,3-b)indole	"2-amino-3-methyl-9H-pyrido(2,3-b)indole results in decreased activity of DDC protein"	2243617
C585004	2-monochloropropanediol	2-monochloropropanediol results in increased expression of DDC mRNA	28522335
C099630	3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine	"[3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine binds to and results in decreased activity of DRD4 protein] which results in increased activity of DDC protein"	16415089
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of DDC mRNA"	20959002
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of DDC mRNA"	23196670
C019132	3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole	"3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in decreased activity of DDC protein"	2243617
C019132	3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole	"3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in decreased activity of DDC protein"	2904812
C019133	3-amino-1-methyl-5H-pyrido(4,3-b)indole	"3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of DDC protein"	2243617
C019133	3-amino-1-methyl-5H-pyrido(4,3-b)indole	"3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of DDC protein"	2904812
C004297	3-hydroxybenzylhydrazine	3-hydroxybenzylhydrazine results in decreased activity of DDC protein	16415089
C004297	3-hydroxybenzylhydrazine	3-hydroxybenzylhydrazine results in decreased activity of DDC protein	20542064
C008745	4,4'-bisphenol F	"4,4'-bisphenol F results in decreased expression of DDC mRNA"	26186136
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of DDC mRNA"	25380136
D000082	Acetaminophen	Acetaminophen results in decreased expression of DDC mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of DDC mRNA	17562736
D012436	S-Adenosylmethionine	[Levodopa co-treated with DDC] results in increased abundance of S-Adenosylmethionine	11445284
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of DDC protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of DDC mRNA	21632981\|2164198
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of DDC gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of DDC mRNA	19770486
D000452	Aldrin	Aldrin results in increased expression of DDC mRNA	18579281
D006710	Homocysteine	[Levodopa co-treated with DDC] results in decreased abundance of Homocysteine	11445284
D000638	Amiodarone	Amiodarone results in increased expression of DDC mRNA	24489787
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of DDC mRNA	16483693
D000643	Ammonium Chloride	Ammonium Chloride results in decreased expression of DDC protein	16483693
D000661	Amphetamine	Amphetamine results in decreased expression of DDC mRNA	8717341
C030419	andrographolide	[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of DDC mRNA	19737545
C030419	andrographolide	andrographolide results in increased expression of DDC mRNA	19737545
D001280	Atrazine	Atrazine results in decreased expression of DDC mRNA	27413107
D001280	Atrazine	Atrazine results in decreased expression of DDC mRNA	22378314
D001379	Azathioprine	Azathioprine results in decreased expression of DDC mRNA	22623647
C547126	AZM551248	AZM551248 results in decreased expression of DDC mRNA	22323515
C487081	belinostat	belinostat results in decreased expression of DDC mRNA	27188386
D001545	Benserazide	Benserazide results in decreased activity of DDC protein	1255483\|17920284
C005177	benserazide, levodopa drug combination	"benserazide, levodopa drug combination results in decreased expression of DDC protein"	2760634
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of DDC mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of DDC mRNA	27858113
D019324	beta-Naphthoflavone	[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of DDC mRNA	19737545
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of DDC mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of DDC mRNA	17879257
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of DDC mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of DDC mRNA	19770486\|2261060
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of DDC mRNA	25566086
D004958	Estradiol	Estradiol results in increased expression of DDC mRNA	20068009
C006780	bisphenol A	bisphenol A affects the expression of DDC mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of DDC mRNA	26364221
C006780	bisphenol A	bisphenol A results in decreased expression of DDC mRNA	25270620
C006780	bisphenol A	bisphenol A results in decreased expression of DDC mRNA	25181051\|2618613
D002065	Buspirone	Buspirone results in decreased expression of DDC mRNA	24136188
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of DDC mRNA	22110744
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of DDC mRNA	25993096
C037123	cadmium sulfate	cadmium sulfate results in increased expression of DDC mRNA	16221973
D002230	Carbidopa	Carbidopa results in decreased activity of DDC protein	1101099\|1255483\|
C009265	carbidopa, levodopa drug combination	"carbidopa, levodopa drug combination results in decreased expression of DDC protein"	2760634
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of DDC mRNA	27339419
C010063	carbonyl sulfide	carbonyl sulfide results in decreased expression of DDC mRNA	19395590
D002509	Cephaloridine	Cephaloridine results in decreased expression of DDC mRNA	18500788
D002713	Chlorine	Chlorine results in decreased expression of DDC mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of DDC mRNA	18636392
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of DDC mRNA	27858113
D002994	Clofibrate	Clofibrate affects the expression of DDC mRNA	16081524
D003024	Clozapine	Clozapine results in increased expression of and results in increased activity of DDC protein	16415089
D003024	Clozapine	Clozapine results in increased expression of DDC mRNA	16415089
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of DDC mRNA	24612858
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of DDC mRNA	24386269
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of DDC mRNA	20971185
D003300	Copper	Copper results in decreased expression of DDC mRNA	22465980
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of DDC mRNA	19549813
D019327	Copper Sulfate	Copper Sulfate results in increased expression of DDC mRNA	18579281
C029892	cupric chloride	cupric chloride results in increased expression of DDC mRNA	24650576
D003471	Cuprizone	Cuprizone results in decreased expression of DDC mRNA	27523638
D016572	Cyclosporine	Cyclosporine results in decreased expression of DDC mRNA	20106945\|2163298
D016572	Cyclosporine	Cyclosporine results in increased expression of DDC mRNA	27989131
C017180	decamethrin	decamethrin results in decreased expression of DDC mRNA	19017407
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of DDC mRNA]	27941970
D003907	Dexamethasone	Dexamethasone results in increased expression of DDC mRNA	22733784
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of DDC mRNA	17379624\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of DDC protein	15728792\|2174549
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of DDC mRNA	21527772
D004147	Dioxins	Dioxins affects the expression of DDC mRNA	20463971
D007980	Levodopa	DDC results in increased susceptibility to Levodopa	16337943
D007980	Levodopa	[Levodopa co-treated with DDC] results in decreased abundance of Homocysteine	11445284
D007980	Levodopa	[Levodopa co-treated with DDC] results in increased abundance of S-Adenosylmethionine	11445284
D007980	Levodopa	Levodopa inhibits the reaction [Oxidopamine results in decreased expression of DDC protein]	20232137
D007980	Levodopa	DDC protein results in decreased degradation of Levodopa	11445284
C118739	entinostat	entinostat results in decreased expression of DDC mRNA	27188386
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of DDC mRNA	15834898\|1590192
D015025	Zearalenone	Zearalenone results in decreased expression of DDC mRNA	24412706
D005485	Flutamide	Flutamide results in decreased expression of DDC mRNA	24793618
C039281	furan	furan results in decreased expression of DDC mRNA	26194646
D019833	Genistein	Genistein results in increased expression of DDC mRNA	15378649
D005897	Glafenine	Glafenine results in decreased expression of DDC mRNA	24136188
D006046	Gold	[Gold co-treated with Polyethylene Glycols] results in decreased expression of DDC mRNA	19695318
D017313	Fenretinide	Fenretinide results in increased expression of DDC mRNA	28973697
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of DDC mRNA	21396975
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of DDC mRNA	26752646
C410337	K 7174	K 7174 results in decreased expression of DDC mRNA	24086573
D007650	Ketanserin	Ketanserin results in increased activity of DDC protein	16415089
D007657	Ketone Bodies	Ketone Bodies results in decreased expression of DDC mRNA	16807920
C008261	lead acetate	lead acetate results in decreased expression of DDC mRNA	22641619
C045463	leflunomide	leflunomide results in decreased expression of DDC mRNA	24136188
D064704	Levofloxacin	Levofloxacin results in decreased expression of DDC mRNA	24136188
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of DDC mRNA"	24972896
D008711	Metergoline	Metergoline results in increased activity of DDC protein	16415089
D008750	Methyldopa	Methyldopa results in decreased activity of DDC protein	4183532
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of DDC mRNA	26558463
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of DDC mRNA	26011545
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of DDC mRNA"	20188158
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of DDC mRNA	26558463
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of DDC mRNA	16026605
C090413	N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide	[N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein] which results in increased activity of DDC protein	16415089
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of DDC mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of DDC mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of DDC mRNA"	25620056
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in decreased expression of DDC mRNA	25380136
C051752	nefazodone	nefazodone results in decreased expression of DDC mRNA	24136188
C012655	nimesulide	nimesulide results in decreased expression of DDC mRNA	24136188
D009569	Nitric Oxide	Nitric Oxide deficiency results in increased activity of DDC protein	7541690
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of DDC mRNA	20971185
D016627	Oxidopamine	Levodopa inhibits the reaction [Oxidopamine results in decreased expression of DDC protein]	20232137
D016627	Oxidopamine	Oxidopamine results in decreased expression of DDC protein	20232137
D010100	Oxygen	Oxygen deficiency results in decreased expression of DDC mRNA	19695866
D010126	Ozone	[Ozone co-treated with NOTCH3 gene mutant form] results in decreased expression of DDC mRNA	25658374
D010126	Ozone	[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of DDC mRNA	25658374
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of DDC mRNA	18636392
D010269	Paraquat	Paraquat results in decreased expression of DDC mRNA	21371552
D010433	Pentylenetetrazole	[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of DDC mRNA	21503142
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of DDC mRNA	18692542
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of DDC mRNA	23427857
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of DDC mRNA	19162173
C027579	periodate-oxidized adenosine	periodate-oxidized adenosine affects the expression of DDC mRNA	17097637
D026023	Permethrin	Permethrin results in decreased expression of DDC mRNA	19017407
D010634	Phenobarbital	Phenobarbital results in decreased expression of DDC mRNA	19270015
D010634	Phenobarbital	Phenobarbital results in increased expression of DDC mRNA	12807726
D010634	Phenobarbital	Phenobarbital results in increased expression of DDC mRNA	19162173
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of DDC mRNA	15728792\|2106145
C006253	pirinixic acid	pirinixic acid results in decreased expression of DDC mRNA	19162173
D011092	Polyethylene Glycols	[Gold co-treated with Polyethylene Glycols] results in decreased expression of DDC mRNA	19695318
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of DDC mRNA	28903501
C005556	propionaldehyde	propionaldehyde results in decreased expression of DDC mRNA	26079696
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in decreased activity of DDC protein	16204272
D011794	Quercetin	Quercetin results in decreased expression of DDC mRNA	21632981
D012110	Reserpine	Reserpine results in increased expression of DDC mRNA	1359376
C059514	resveratrol	resveratrol results in increased expression of DDC mRNA	18586690
D015474	Isotretinoin	Isotretinoin results in decreased expression of DDC mRNA	20436886
D012524	Sarin	Sarin results in decreased expression of DDC mRNA	19522546
D012524	Sarin	Sarin results in decreased expression of DDC protein	19522546
D012601	Scopolamine Hydrobromide	Scopolamine Hydrobromide results in decreased expression of DDC mRNA	17540011
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of DDC mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of DDC mRNA	23221170
C009277	sodium arsenate	sodium arsenate results in increased expression of DDC mRNA	23922661
C017947	sodium arsenite	[sodium arsenite affects the localization of NR4A2 protein] inhibits the reaction [NR4A2 protein results in increased expression of DDC mRNA]	23283970
C017947	sodium arsenite	sodium arsenite results in decreased expression of DDC mRNA	23283970
C016104	sodium bichromate	sodium bichromate affects the expression of DDC mRNA	22110744
C016104	sodium bichromate	sodium bichromate results in decreased expression of DDC mRNA	25993096
D012999	Soman	Soman results in decreased expression of DDC mRNA	19281266
D015085	2,4,5-Trichlorophenoxyacetic Acid	"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of DDC mRNA"	18579281
D013629	Tamoxifen	Tamoxifen affects the expression of DDC mRNA	20937368
D013739	Testosterone	Testosterone results in increased expression of DDC mRNA	19693291
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of DDC mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DDC mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of DDC mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to DDC gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of DDC mRNA	19770486\|1993321
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DDC mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of DDC mRNA	19490992\|2095900
D013752	Tetracycline	Tetracycline results in decreased expression of DDC mRNA	24489787
D019284	Thapsigargin	Thapsigargin results in decreased expression of DDC mRNA	22378314
D013853	Thioacetamide	Thioacetamide results in decreased expression of DDC mRNA	23411599
C009495	titanium dioxide	titanium dioxide results in decreased expression of DDC mRNA	27760801
D014212	Tretinoin	Tretinoin results in decreased expression of DDC mRNA	20530235
D014212	Tretinoin	Tretinoin results in decreased expression of DDC mRNA	23724009
D014212	Tretinoin	Tretinoin results in increased expression of DDC mRNA	21934132
D014212	Tretinoin	Tretinoin results in increased expression of DDC mRNA	16604517
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of DDC mRNA	25549359
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DDC mRNA"	26179874
D014415	Tunicamycin	Tunicamycin results in decreased expression of DDC mRNA	22378314
D014520	Urethane	Urethane results in decreased expression of DDC mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of DDC mRNA	25979313
D014640	Vancomycin	Vancomycin results in increased expression of DDC mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of DDC gene	25560391
D020888	Vigabatrin	[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of DDC mRNA	21503142
D020888	Vigabatrin	Vigabatrin results in decreased expression of DDC mRNA	8717341
D024483	Vitamin K 3	Vitamin K 3 affects the expression of DDC mRNA	20044591
C111237	vorinostat	vorinostat results in decreased expression of DDC mRNA	27188386
D015034	Zinc Oxide	Zinc Oxide analog results in decreased expression of DDC mRNA	27215404
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of DDC mRNA	27215404

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004058	aromatic-L-amino-acid decarboxylase activity	-	IDA	16338639
GO:0004058	aromatic-L-amino-acid decarboxylase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	12864730 19703902
GO:0016597	amino acid binding	-	IEA	-
GO:0019899	enzyme binding	-	IPI	19703902
GO:0019904	protein domain specific binding	-	IEA	-
GO:0030170	pyridoxal phosphate binding	-	IEA	-
GO:0036468	L-dopa decarboxylase activity	-	IDA	19703902

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006520	cellular amino acid metabolic process	-	IEA	-
GO:0007623	circadian rhythm	-	IEA	-
GO:0010259	multicellular organism aging	-	IEA	-
GO:0015842	aminergic neurotransmitter loading into synaptic vesicle	-	IEA	-
GO:0033076	isoquinoline alkaloid metabolic process	-	IEA	-
GO:0035690	cellular response to drug	-	IEA	-
GO:0042416	dopamine biosynthetic process	-	IEA	-
GO:0042423	catecholamine biosynthetic process	-	TAS	-
GO:0042427	serotonin biosynthetic process	-	IEA	-
GO:0046219	indolalkylamine biosynthetic process	-	TAS	-
GO:0046684	response to pyrethroid	-	IEA	-
GO:0052314	phytoalexin metabolic process	-	IEA	-
GO:0071312	cellular response to alkaloid	-	IEA	-
GO:0071363	cellular response to growth factor stimulus	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	TAS	-
GO:0008021	synaptic vesicle	-	IEA	-
GO:0030424	axon	-	IEA	-
GO:0043025	neuronal cell body	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867

KEGG ID	KEGG Term
hsa00340	Histidine metabolism
hsa00350	Tyrosine metabolism
hsa00360	Phenylalanine metabolism
hsa00380	Tryptophan metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-209776	Amine-derived hormones	TAS
R-HSA-209905	Catecholamine biosynthesis	TAS
R-HSA-209931	Serotonin and melatonin biosynthesis	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25875614	Overlapping dopaminergic pathway genetic susceptibility to heroin and cocaine addictions in African Americans. (2015 May)	Levran O	Ann Hum Genet
21806388	Dopamine-related genes and spontaneous smoking cessation in ever-heavy smokers. (2011 Aug)	Breitling LP	Pharmacogenomics
28811616	Synthesis-free PET imaging of brown adipose tissue and TSPO via combination of disulfiram and (64)CuCl2. (2017 Aug 15)	Yang J	Sci Rep
26451072	Assessing the impact of nicotine dependence genes on the risk of facial clefts: An example of the use of national registry and biobank data. (2012)	Jugessur A	Nor Epidemiol
8392551	Diethyldithiocarbamate S-methylation: evidence for catalysis by human liver thiol methyltransferase and thiopurine methyltransferase. (1993 Jul)	Glauser TA	J Pharmacol Exp Ther
23953852	Genome-wide association studies of maximum number of drinks. (2013 Nov)	Pan Y	J Psychiatr Res
26503115	Polymorphisms in early neurodevelopmental genes affect natural variation in alcohol sensitivity in adult drosophila. (2015 Oct 26)	Morozova TV	BMC Genomics
25545355	Genetic variants and early cigarette smoking and nicotine dependence phenotypes in adolescents. (2014)	O'Loughlin J	PLoS One
10803680	Role of polymorphic CYP2E1 and CYP2D6 genes in NNK-induced chromosome aberrations in cultured human lymphocytes. (2000 Apr)	Abdel-Rahman SZ	Pharmacogenetics
16740595	Intronic variants in the dopa decarboxylase (DDC) gene are associated with smoking behavior in European-Americans and African-Americans. (2006 Jul 15)	Yu Y	Hum Mol Genet
15879433	Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence. (2005 Jun 15)	Ma JZ	Hum Mol Genet
21797889	The relationship between rs3779084 in the dopa decarboxylase (DDC) gene and alcohol consumption is mediated by drinking motives in regular smokers. (2012 Jan)	Kristjansson SD	Alcohol Clin Exp Res
21083670	Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). (2011 Feb)	Hack LM	Alcohol Clin Exp Res
22309839	Association study of 45 candidate genes in nicotine dependence in Han Chinese. (2012 May)	Wei J	Addict Behav
17184203	DOPA decarboxylase gene is associated with nicotine dependence. (2006 Dec)	Zhang H	Pharmacogenomics