Gene info: ID 2104

Gene: ESRRG

GENE ID: 2104

Synonyms: ERR-gamma|ERR3|ERRg|ERRgamma|NR3B3

Description: estrogen related receptor gamma

Gene type: protein-coding

Location: 1q41

dbXrefs: Ensembl:ENSG00000196482 MIM:602969 Vega:OTTHUMG00000037025 UniprotKB:P62508

RefSeq: NG_029784.1

Retrived from: PubMed|SNP Mapped

SNPs: 4 ANCO-SNPs

Phenotype: ND|AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.812e-1 (AD) 7.537e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs11572505	chr1:216920702 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs1436899	chr1:216884140 (GRCh38.p7)	A>G	nicotine dependence	SNV(Single Nucleotide Variation)
rs72737330	chr1:216600151 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs7553212	chr1:216565446 (GRCh38.p7)	A>G / A>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg17011300	chr1:217260830	ESRRG	Promoter	1.545e-4	Alcohol use disorders	26763658
cg17434154	chr1:217306590	ESRRG	Promoter	2.229e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OXR1	0.914
EIF5A2	0.912
CDK14	0.911
B4GALT6	0.909
RIMKLA	0.909
PLCB1	0.908
HCN1	0.907
FRMPD4	0.905
SCN1A	0.905
TRHDE	0.901

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RAB13	-0.626
ROM1	-0.583
EMP3	-0.57
S100A16	-0.564
TIMP1	-0.564
MYL3	-0.562
CSAG1	-0.561
CMTM3	-0.559
FLT3LG	-0.546
RNF135	-0.546

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00197	Troglitazone	Small Molecule	97322-87-7	Investigational\|Withdrawn	Target
DB00255	Diethylstilbestrol	Small Molecule	56-53-1	Approved\|Investigational	Target
DB00675	Tamoxifen	Small Molecule	10540-29-1	Approved	Target
DB00783	Estradiol	Small Molecule	50-28-2	Approved\|Investigational	Target
DB02659	Cholic Acid	Small Molecule	81-25-4	Approved	Target
DB04468	Afimoxifene	Small Molecule	68392-35-8	Investigational	Target
DB06884	4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE	Small Molecule		Experimental	Target
DB06902	4-(1-methyl-1-phenylethyl)phenol	Small Molecule		Experimental	Target
DB06973	4,4'-PROPANE-2,2-DIYLDIPHENOL	Small Molecule		Experimental	Target
DB07485	4,4'-cyclohexane-1,1-diyldiphenol	Small Molecule		Experimental	Target
DB13952	Estradiol acetate	Small Molecule	4245-41-4	Approved\|Investigational	Target
DB13953	Estradiol benzoate	Small Molecule	50-50-0	Approved\|Investigational	Target
DB13954	Estradiol cypionate	Small Molecule	313-06-4	Approved\|Investigational	Target
DB13955	Estradiol dienanthate	Small Molecule	7732-97-0	Approved\|Investigational	Target
DB13956	Estradiol valerate	Small Molecule	979-32-8	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C006718	1,12-benzoperylene	"1,12-benzoperylene results in increased expression of ESRRG mRNA"	26377693
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ESRRG mRNA	19933214
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of ESRRG mRNA]	27038254
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of ESRRG protein]	26363202\|2703825
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of ESRRG mRNA]	27038254
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of ESRRG protein]	27038254
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ESRRG mRNA"	23196670
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ESRRG mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ESRRG mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ESRRG mRNA"	27188386
C516284	4-cumylphenol	4-cumylphenol analog binds to ESRRG protein	18582436
C062262	4-hydroxytoremifene	4-hydroxytoremifene results in decreased activity of ESRRG protein	15149736
C062262	4-hydroxytoremifene	4-hydroxytoremifene binds to and results in decreased activity of ESRRG protein	16515477
C028690	4-isopropylphenol	4-isopropylphenol binds to ESRRG protein	27486708
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ESRRG mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ESRRG mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ESRRG mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of ESRRG mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of ESRRG mRNA	17562736
C016601	afimoxifene	afimoxifene binds to and affects the activity of ESRRG protein	16889744
C016601	afimoxifene	afimoxifene binds to and results in decreased activity of ESRRG protein	11447273\|1475122
C016601	afimoxifene	afimoxifene binds to and results in decreased activity of [ESRRG protein binds to ESRRA protein]	14751226
C016601	afimoxifene	afimoxifene binds to ESRRG protein	17964775\|2054289
C016601	afimoxifene	afimoxifene inhibits the reaction [ESRRG protein binds to NCOA1 protein]	11447273
C016601	afimoxifene	afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]	23583298
C016601	afimoxifene	afimoxifene inhibits the reaction [PPARGC1A protein binds to ESRRG protein]	16889744
C016601	afimoxifene	afimoxifene results in decreased activity of ESRRG protein	15149736
C016601	afimoxifene	benzylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C016601	afimoxifene	bisphenol A inhibits the reaction [afimoxifene binds to and results in decreased activity of ESRRG protein]	18197296
C016601	afimoxifene	bisphenol A inhibits the reaction [afimoxifene binds to ESRRG protein]	17964775
C016601	afimoxifene	bisphenol A inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C016601	afimoxifene	butylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C016601	afimoxifene	chlorocresol inhibits the reaction [afimoxifene binds to ESRRG protein]	17964775
C016601	afimoxifene	ethyl-p-hydroxybenzoate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C016601	afimoxifene	ethyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C016601	afimoxifene	methylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C016601	afimoxifene	methyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C016601	afimoxifene	propylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C016601	afimoxifene	afimoxifene binds to and results in decreased activity of ESRRG protein	15161930
C016601	afimoxifene	afimoxifene binds to and results in decreased activity of ESRRG protein	23645310
C016601	afimoxifene	afimoxifene inhibits the reaction [bisphenol A binds to and results in increased activity of ESRRG protein]	23645310
C016601	afimoxifene	afimoxifene binds to and results in decreased activity of ESRRG protein	16515477
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of ESRRG protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of ESRRG gene	27153756
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of ESRRG mRNA	21298039
D001151	Arsenic	Arsenic affects the methylation of ESRRG gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in increased expression of ESRRG mRNA	20458559
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the expression of ESRRG mRNA"	17331233
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ESRRG mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the reaction [AHR protein binds to ESRRG promoter]	19654925
C057775	benzylparaben	benzylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
D004958	Estradiol	Estradiol binds to ESRRG protein	22935422
D004958	Estradiol	Estradiol results in increased expression of ESRRG mRNA	25878060
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in decreased expression of ESRRG mRNA	26496021
C044887	beta-methylcholine	beta-methylcholine affects the expression of ESRRG mRNA	21179406
C004541	biochanin A	biochanin A promotes the reaction [ESRRG protein binds to PNRC1 protein]	14638870
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of ESRRG mRNA	25111128
C006780	bisphenol A	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of ESRRG mRNA]	27038254
C006780	bisphenol A	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of ESRRG protein]	26363202\|2703825
C006780	bisphenol A	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of ESRRG mRNA]	27038254
C006780	bisphenol A	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of ESRRG protein]	27038254
C006780	bisphenol A	bisphenol A analog binds to ESRRG protein	18197296\|2293542
C006780	bisphenol A	bisphenol A binds to and results in increased activity of ESRRG protein	20427257
C006780	bisphenol A	bisphenol A binds to ESRRG protein	17761695\|1796477
C006780	bisphenol A	bisphenol A inhibits the reaction [afimoxifene binds to and results in decreased activity of ESRRG protein]	18197296
C006780	bisphenol A	bisphenol A inhibits the reaction [afimoxifene binds to ESRRG protein]	17964775
C006780	bisphenol A	bisphenol A inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C006780	bisphenol A	bisphenol A results in increased expression of and affects the localization of ESRRG protein	26363202
C006780	bisphenol A	bisphenol A results in increased expression of ESRRG mRNA	22121209\|2587806
C006780	bisphenol A	bisphenol A results in increased expression of ESRRG protein	27038254
C006780	bisphenol A	ESRRG protein affects the reaction [bisphenol A results in increased expression of MMP2 mRNA]	27038254
C006780	bisphenol A	ESRRG protein affects the reaction [bisphenol A results in increased expression of MMP2 protein]	27038254
C006780	bisphenol A	ESRRG protein affects the reaction [bisphenol A results in increased expression of MMP9 mRNA]	27038254
C006780	bisphenol A	ESRRG protein affects the reaction [bisphenol A results in increased expression of MMP9 protein]	27038254
C006780	bisphenol A	bisphenol A affects the expression of ESRRG mRNA	23716699
C006780	bisphenol A	bisphenol A affects the methylation of ESRRG promoter	27334623
C006780	bisphenol A	bisphenol A results in increased expression of ESRRG mRNA	21123812\|2270747
C006780	bisphenol A	afimoxifene inhibits the reaction [bisphenol A binds to and results in increased activity of ESRRG protein]	23645310
C006780	bisphenol A	bisphenol A binds to and results in increased activity of ESRRG protein	23645310
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in decreased expression of ESRRG mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of ESRRG mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of ESRRG gene	28505145
C006780	bisphenol A	ESRRG protein results in increased susceptibility to bisphenol A	22281313
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of ESRRG mRNA	22079614
C038091	butylparaben	butylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
D002220	Carbamazepine	Carbamazepine affects the expression of ESRRG mRNA	25979313
C006984	chlorocresol	chlorocresol binds to ESRRG protein	17964775
C006984	chlorocresol	chlorocresol inhibits the reaction [afimoxifene binds to ESRRG protein]	17964775
D016572	Cyclosporine	Cyclosporine results in decreased expression of ESRRG mRNA	20106945
C004742	daidzein	daidzein promotes the reaction [ESRRG protein binds to PNRC1 protein]	14638870
D016047	Zalcitabine	"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ESRRG mRNA"	18606552
D004041	Dietary Fats	Dietary Fats results in increased expression of ESRRG mRNA	18042831\|2501614
D004054	Diethylstilbestrol	Diethylstilbestrol binds to and affects the activity of ESRRG protein	16889744
D004054	Diethylstilbestrol	Diethylstilbestrol binds to and results in decreased activity of ESRRG protein	11559547\|1475122
D004054	Diethylstilbestrol	Diethylstilbestrol binds to and results in increased activity of ESRRG protein	12579585
D004054	Diethylstilbestrol	Diethylstilbestrol binds to ESRRG protein	11447273\|1704919
D004054	Diethylstilbestrol	Diethylstilbestrol inhibits the reaction [ESRRG protein results in increased expression of TFF1 mRNA]	11559547
D004054	Diethylstilbestrol	Diethylstilbestrol binds to and results in decreased activity of ESRRG protein	15161930
D004054	Diethylstilbestrol	Diethylstilbestrol binds to and results in increased activity of ESRRG protein	12579585
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of ESRRG mRNA	22710028
D004054	Diethylstilbestrol	Diethylstilbestrol binds to and results in decreased activity of ESRRG protein	16515477
C012313	ethyl-p-hydroxybenzoate	ethyl-p-hydroxybenzoate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C041835	ethyl salicylate	ethyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
D005284	Fenthion	Fenthion results in increased activity of ESRRG protein	20143881
C039281	furan	furan results in increased methylation of ESRRG gene	22079235
D019833	Genistein	Genistein promotes the reaction [ESRRG protein binds to PNRC1 protein]	14638870
C514793	gp120 protein, Human immunodeficiency virus 1	"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ESRRG mRNA"	18606552
C545235	GSK 4716	GSK 4716 binds to ESRRG protein	21958216
D017313	Fenretinide	Fenretinide results in increased expression of ESRRG mRNA	28973697
D018021	Lithium Chloride	Lithium Chloride results in increased expression of ESRRG mRNA	23527032
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of ESRRG mRNA	28001369
C015358	methylparaben	methylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C033069	methyl salicylate	methyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C501618	N'-((1E)-(4-(diethylamino)phenyl)methylene)-4-hydroxybenzohydrazide	N'-((1E)-(4-(diethylamino)phenyl)methylene)-4-hydroxybenzohydrazide binds to and results in increased activity of ESRRG protein	15713377
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of ESRRG mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of ESRRG mRNA"	25554681\|2562005
D009532	Nickel	Nickel results in decreased expression of ESRRG mRNA	24768652\|2558310
D000073878	Palm Oil	Palm Oil results in increased expression of ESRRG mRNA	18042831
D010578	Petroleum	Petroleum results in increased expression of ESRRG mRNA	25208076
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ESRRG mRNA"	27188386
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ESRRG mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of ESRRG mRNA	18301758\|2081375
C006068	propylparaben	propylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C089730	rosiglitazone	rosiglitazone results in decreased expression of ESRRG mRNA	25572481
C017947	sodium arsenite	sodium arsenite affects the methylation of ESRRG gene	28589171
D013629	Tamoxifen	Tamoxifen binds to and affects the activity of ESRRG protein	16889744
D013629	Tamoxifen	Tamoxifen binds to ESRRG protein	11447273
D013629	Tamoxifen	Tamoxifen inhibits the reaction [PPARGC1A protein binds to ESRRG protein]	16889744
C004648	testosterone enanthate	testosterone enanthate affects the expression of ESRRG mRNA	17440010
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ESRRG mRNA	26377647\|2892240
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of ESRRG mRNA	16214954
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ESRRG promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ESRRG mRNA	24058054
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ESRRG mRNA	26290441
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ESRRG mRNA	22298810
D019284	Thapsigargin	Thapsigargin results in decreased expression of ESRRG mRNA	22378314
D014212	Tretinoin	Tretinoin results in increased expression of ESRRG mRNA	23724009
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of ESRRG gene	27618143
C012589	trichostatin A	trichostatin A results in increased activity of ESRRG protein	11705994
C012589	trichostatin A	trichostatin A results in increased expression of ESRRG mRNA	24935251
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of ESRRG mRNA	19042947
D014415	Tunicamycin	Tunicamycin results in decreased expression of ESRRG mRNA	22378314
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ESRRG mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of ESRRG mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of ESRRG gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of ESRRG mRNA	23179753\|2438349
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of ESRRG gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of ESRRG mRNA	19015723
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of ESRRG mRNA	26682919
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ESRRG mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of ESRRG mRNA	26272509
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased expression of ESRRG mRNA"	25208076
C088658	zoledronic acid	zoledronic acid results in decreased expression of ESRRG mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	-	IEA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	-	IEA	-
GO:0003707	steroid hormone receptor activity	-	IEA	-
GO:0003708	retinoic acid receptor activity	-	IEA	-
GO:0005496	steroid binding	-	IEA	-
GO:0005515	protein binding	-	IPI	10428842 18063693 19171140 19914244 25416956
GO:0008270	zinc ion binding	-	IEA	-
GO:0050682	AF-2 domain binding	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006355	regulation of transcription, DNA-templated	-	IDA	23836911
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	-
GO:0043401	steroid hormone mediated signaling pathway	-	IEA	-
GO:0045893	positive regulation of transcription, DNA-templated	-	ISS	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	-
GO:0048384	retinoic acid receptor signaling pathway	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005654	nucleoplasm	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-383280	Nuclear Receptor transcription pathway	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29535761	A Genome-Wide Search for Gene-Environment Effects in Isolated Cleft Lip with or without Cleft Palate Triads Points to an Interaction between Maternal Periconceptional Vitamin Use and Variants in ESRRG. (2018)	Haaland OA	Front Genet