Gene: SPATA13

221178
ARHGEF29|ASEF2
spermatogenesis associated 13
protein-coding
13q12.12
Ensembl:ENSG00000273167 MIM:613324 Vega:OTTHUMG00000186016 UniprotKB:Q96N96
NC_000013.11
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.181e-1 (AD)  1.170e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7982678chr13:24144267 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs736081chr13:24085587 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs9805786chr13:24084217 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25643223chr13:24787195SPATA138.640e-9Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SFT2D20.896
CREB3L20.874
CLIC40.871
LITAF0.869
BAZ1A0.867
PARP40.862
SLC35D20.859
HPS50.858
FAM114A10.857
ELF10.856

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDH22-0.513
ADRA1D-0.505
ABCC12-0.501
FBLN7-0.498
NEUROD6-0.483
BEAN1-0.482
RTN4R-0.472
TCERG1L-0.471
YBX2-0.47
ASB2-0.469

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SPATA13 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SPATA13 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SPATA13 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SPATA13 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SPATA13 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SPATA13 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPATA13 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPATA13 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SPATA13 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SPATA13 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of SPATA13 mRNA21298039
D001104ArbutinArbutin results in increased expression of SPATA13 mRNA17103032
C006632arsenic trioxidearsenic trioxide results in increased expression of SPATA13 mRNA20458559
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SPATA13 mRNA"19150397
D004958EstradiolESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to SPATA13 gene]]17962382
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to SPATA13 gene]17962382
D004958EstradiolEstradiol results in increased expression of SPATA13 mRNA17962382|2301914
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SPATA13 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of SPATA13 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SPATA13 gene28505145
D002922CiguatoxinsCiguatoxins affects the expression of SPATA13 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of SPATA13 mRNA23811191
D019327Copper SulfateCopper Sulfate results in decreased expression of SPATA13 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of SPATA13 mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SPATA13 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SPATA13 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SPATA13 mRNA27392435
D002945CisplatinCisplatin results in increased expression of SPATA13 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of SPATA13 mRNA28302478
D019422Dietary SucroseDietary Sucrose results in increased expression of SPATA13 mRNA26033743
D005557FormaldehydeFormaldehyde results in decreased expression of SPATA13 mRNA27664576
C039281furanfuran results in decreased expression of SPATA13 mRNA25539665|2738771
D017313FenretinideFenretinide results in increased expression of SPATA13 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SPATA13 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SPATA13 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SPATA13 mRNA27392435
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SPATA13 mRNA25890327
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SPATA13 mRNA21641980
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SPATA13 mRNA26011545
C523799MRK 003SPATA13 results in decreased susceptibility to MRK 00319903844
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SPATA13 mRNA"25510870
C006253pirinixic acidpirinixic acid results in decreased expression of SPATA13 mRNA23811191
C045950propiconazolepropiconazole results in decreased expression of SPATA13 mRNA21278054
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of SPATA13 mRNA17962382
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SPATA13 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SPATA13 mRNA19073995
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SPATA13 mRNA21641980
D013629TamoxifenTamoxifen results in increased expression of SPATA13 mRNA17962382
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SPATA13 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SPATA13 mRNA26290441
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SPATA13 mRNA28111298
D014212TretinoinTretinoin results in decreased expression of SPATA13 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of SPATA13 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SPATA13 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of SPATA13 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPATA13 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of SPATA13 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of SPATA13 gene29154799
C025643vinclozolinvinclozolin results in decreased expression of SPATA13 mRNA23034163
D019287Zinc SulfateZinc Sulfate results in decreased expression of SPATA13 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005085guanyl-nucleotide exchange factor activity-IDA19934221  
GO:0005085guanyl-nucleotide exchange factor activity-IMP17145773  17599059  
GO:0005515protein binding-IPI17145773  17599059  19151759  
GO:0030676Rac guanyl-nucleotide exchange factor activity-IDA19934221  
GO:0030676Rac guanyl-nucleotide exchange factor activity-IMP17599059  
GO ID GO Term Qualifier Evidence PubMed
GO:0016477cell migration-IMP17145773  19151759  
GO:0030032lamellipodium assembly-IMP17599059  
GO:0030334regulation of cell migration-IMP17599059  19934221  
GO:0035023regulation of Rho protein signal transduction-IEA-  
GO:0046847filopodium assembly-IMP17145773  17599059  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA19151759  
GO:0005829cytosol-IDA-  
GO:0030027lamellipodium-IDA17599059  19151759  
GO:0030175filopodium-IDA17599059  
GO:0032587ruffle membrane-IDA19151759  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal