Gene: ZFPM2

23414
DIH3|FOG2|SRXY9|ZC2HC11B|ZNF89B|hFOG-2
zinc finger protein, FOG family member 2
protein-coding
8q23.1
Ensembl:ENSG00000169946 MIM:603693 Vega:OTTHUMG00000164818 UniprotKB:Q8WW38
NG_011723.1
SNP Mapped
4   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.297e-1 (AD)  1.406e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1037306chr8:105549049 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs302964chr8:105506184 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs302960chr8:105505449 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs2880439chr8:105256967 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04640109chr8:106330173ZFPM21.050e-9Maternal smoking in pregnancy27040690
cg04640109chr8:106330173ZFPM26.570e-13Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCTD160.915
RAPGEF20.913
PHLPP20.912
ARHGEF30.906
FRY0.903
CHL10.902
CHRM30.901
PPM1L0.901
THRB0.901
BHLHB90.9

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BCL7C-0.482
HEY2-0.475
COPZ2-0.458
RAB13-0.446
ROM1-0.44
FLT3LG-0.432
RAI14-0.429
MYL3-0.425
MDFI-0.424
AQP5-0.424

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ZFPM2 mRNA19933214
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ZFPM2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZFPM2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFPM2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFPM2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZFPM2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFPM2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFPM2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ZFPM2 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of ZFPM2 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of ZFPM2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ZFPM2 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ZFPM2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of ZFPM2 mRNA22521957
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of ZFPM2 mRNA"20382639
D004958EstradiolEstradiol results in decreased expression of ZFPM2 mRNA25210133
C006780bisphenol Abisphenol A results in decreased expression of ZFPM2 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of ZFPM2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ZFPM2 gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ZFPM2 mRNA17484886
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZFPM2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of ZFPM2 mRNA26272509
D003042CocaineCocaine results in decreased expression of ZFPM2 mRNA17898221
D016572CyclosporineCyclosporine results in increased expression of ZFPM2 mRNA20106945
D003561CytarabineCytarabine results in decreased expression of ZFPM2 mRNA21198554
D004041Dietary FatsDietary Fats results in decreased expression of ZFPM2 mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ZFPM2 mRNA27060630
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of ZFPM2 gene16724327
D005557FormaldehydeFormaldehyde results in decreased expression of ZFPM2 mRNA20655997
D019833GenisteinGenistein results in decreased expression of ZFPM2 mRNA15256057
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ZFPM2 mRNA28001369
D008777MethyltestosteroneMethyltestosterone results in decreased expression of ZFPM2 mRNA29191790
C568376MT19c compoundMT19c compound results in increased expression of ZFPM2 mRNA21781307
D009532NickelNickel results in decreased expression of ZFPM2 mRNA25583101
C022838nickel chloridenickel chloride results in increased expression of ZFPM2 mRNA17312168
C028007nickel monoxidenickel monoxide results in decreased expression of ZFPM2 mRNA19167457
D010656PhenylephrineZFPM2 protein results in decreased susceptibility to Phenylephrine15220332
D010656PhenylephrineZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]15220332
D010656PhenylephrineZFPM2 protein inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]15220332
D010656PhenylephrineZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]15220332
D010656PhenylephrineZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]15220332
D010656PhenylephrineZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]15220332
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFPM2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ZFPM2 mRNA26272509
D011441PropylthiouracilPropylthiouracil results in increased expression of ZFPM2 mRNA24780913
D012822Silicon DioxideSilicon Dioxide results in increased expression of ZFPM2 mRNA25351596
D012834SilverSilver results in decreased expression of ZFPM2 mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of ZFPM2 gene28589171
D012999SomanSoman results in decreased expression of ZFPM2 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ZFPM2 mRNA18691609|1993321
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ZFPM2 mRNA20133372
D014118Toxins, Biological"Toxins, Biological affects the expression of ZFPM2 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of ZFPM2 mRNA21934132
C012589trichostatin Atrichostatin A results in decreased expression of ZFPM2 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of ZFPM2 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFPM2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of ZFPM2 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in decreased expression of ZFPM2 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ZFPM2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001085RNA polymerase II transcription factor binding-IBA21873635  
GO:0003677DNA binding-IEA-  
GO:0003713transcription coactivator activity-NAS10438528  
GO:0003714transcription corepressor activity-IDA10438528  
GO:0005515protein binding-IPI10438528  19723756  20705609  21220346  
GO:0008134transcription factor binding-IPI10438528  
GO:0008270zinc ion binding-NAS10438528  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001570vasculogenesis-IEA-  
GO:0001701in utero embryonic development-IEA-  
GO:0003148outflow tract septum morphogenesis-IMP20807224  
GO:0003221right ventricular cardiac muscle tissue morphogenesis-IMP20807224  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007506gonadal mesoderm development-IEA-  
GO:0007507heart development-IBA21873635  
GO:0007596blood coagulation-TAS-  
GO:0030154cell differentiation-IBA21873635  
GO:0030324lung development-IEA-  
GO:0045599negative regulation of fat cell differentiation-IMP20705609  
GO:0045892negative regulation of transcription, DNA-templated-IDA20206639  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA10438528  
GO:0048568embryonic organ development-IEA-  
GO:0060045positive regulation of cardiac muscle cell proliferation-IEA-  
GO:0060412ventricular septum morphogenesis-IMP20807224  
GO:0060548negative regulation of cell death-IEA-  
GO:2000020positive regulation of male gonad development-IEA-  
GO:2000195negative regulation of female gonad development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal