Gene: CTNNA3

29119
ARVD13|VR22
catenin alpha 3
protein-coding
10q21.3
Ensembl:ENSG00000183230 MIM:607667 Vega:OTTHUMG00000018334 UniprotKB:Q9UI47
NG_034072.1
PubMed|SNP Mapped
7   ANCO-SNPs
ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.249e-1 (AD)  7.402e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7069964chr10:67486714 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10997651chr10:67462712 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2394340chr10:67101514 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs9332406chr10:66910441 (GRCh38.p7)C>Anicotine dependenceSNV(Single Nucleotide Variation)
rs4142041chr10:66881193 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs1880046chr10:66878053 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs10997361chr10:66722696 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLCO1A20.927
MOBP0.916
PAIP2B0.907
LPAR10.896
ZFP570.896
ERMN0.891
ZEB20.882
ARHGEF370.882
BCAS10.879
RASSF20.878

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCDH8-0.612
CUX2-0.59
CDH22-0.568
POU3F1-0.563
KCNK3-0.554
ASB2-0.548
KCNQ4-0.544
SHROOM3-0.544
HCN4-0.54
IGSF3-0.534

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in decreased expression of CTNNA3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CTNNA3 gene27153756
C006780bisphenol Abisphenol A affects the expression of CTNNA3 mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of CTNNA3 protein28903499
D003471CuprizoneCuprizone results in decreased expression of CTNNA3 mRNA27523638
D003485CyanatesCTNNA3 SNP results in increased susceptibility to Cyanates22977168
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of CTNNA3 mRNA28962523
C008261lead acetatelead acetate results in increased expression of CTNNA3 mRNA22641619
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CTNNA3 mRNA"26251327
D009151Mustard GasMustard Gas results in decreased expression of CTNNA3 mRNA18988085
C028007nickel monoxidenickel monoxide results in decreased expression of CTNNA3 mRNA19167457
D010634PhenobarbitalPhenobarbital results in decreased expression of CTNNA3 mRNA19084549
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CTNNA3 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of CTNNA3 mRNA20813756
D011441PropylthiouracilPropylthiouracil results in decreased expression of CTNNA3 mRNA24780913
C017947sodium arsenitesodium arsenite affects the methylation of CTNNA3 gene28589171
D012969Sodium FluorideSodium Fluoride results in increased expression of CTNNA3 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CTNNA3 mRNA21570461
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CTNNA3 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of CTNNA3 mRNA22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11590244  22190034  23136403  
GO:0008013beta-catenin binding-IPI23136403  
GO:0045296cadherin binding-TAS11590244  
GO:0051015actin filament binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0086073bundle of His cell-Purkinje myocyte adhesion involved in cell communication-IMP23136403  
GO:0086091regulation of heart rate by cardiac conduction-IMP23136403  
GO:0098609cell-cell adhesion-IPI11590244  
GO:0098911regulation of ventricular cardiac muscle cell action potential-IMP23136403  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005856cytoskeleton-IEA-  
GO:0005916fascia adherens-IDA11590244  
GO:0030027lamellipodium-IEA-  
KEGG ID KEGG Term
hsa04520Adherens junction
hsa04530Tight junction
hsa04670Leukocyte transendothelial migration
hsa05100Bacterial invasion of epithelial cells
hsa05200Pathways in cancer
hsa05213Endometrial cancer
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24890784Exon microarray analysis of human dorsolateral prefrontal cortex in alcoholism. (2014 Jun)Manzardo AMAlcohol Clin Exp Res
27613936High Prevalence of Smoking in the Roma Population Seems to Have No Genetic Background. (2016 Dec)Fiatal SNicotine Tob Res
25781172Infection and inflammation in schizophrenia and bipolar disorder: a genome wide study for interactions with genetic variation. (2015)Avramopoulos DPLoS One
22977168CTNNA3 (alpha-catenin) gene variants are associated with diisocyanate asthma: a replication study in a Caucasian worker population. (2013 Jan)Bernstein DIToxicol Sci
20675872[Risk factors for Alzheimer's disease]. (2010 Jul)Ikeda TBrain Nerve