Gene info: ID 2913

Gene: GRM3

GENE ID: 2913

Synonyms: GLUR3|GPRC1C|MGLUR3|mGlu3

Description: glutamate metabotropic receptor 3

Gene type: protein-coding

Location: 7q21.11-q21.12

dbXrefs: Ensembl:ENSG00000198822 MIM:601115 Vega:OTTHUMG00000022884 UniprotKB:Q14832

RefSeq: NC_000007.14

Retrived from: PubMed|SNP Mapped

SNPs: 3 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 6

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.012e-1 (AD) 8.553e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs6465083	chr7:86732020 (GRCh38.p7)	C>T	nicotine dependence	SNV(Single Nucleotide Variation)
rs2237547	chr7:86718721 (GRCh38.p7)	A>C / A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs2189816	chr7:86712130 (GRCh38.p7)	T>C	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NLGN3	0.835
FAM171A1	0.816
NCAM1	0.813
PCCB	0.812
CTSF	0.812
GRID1	0.81
GNAO1	0.809
FUT9	0.801
TOM1L2	0.8
PTPRA	0.797

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.611
OR4F29	-0.576
TFPI2	-0.456
TNFAIP8	-0.439
SIX1	-0.434
SLAMF6	-0.427
FCER2	-0.427
CD48	-0.419
C19orf33	-0.412
C16orf54	-0.41

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB05096	LY2140023	Small Molecule	-	Investigational	Target

ID	Drug Name	Action	PubMed
C082313	2-(2,3-dicarboxycyclopropyl)glycine	"2-(2,3-dicarboxycyclopropyl)glycine results in increased activity of GRM3 protein"	17179862
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of GRM3 mRNA"	20638727
C009407	2,5,2',5'-tetrachlorobiphenyl	"2,5,2',5'-tetrachlorobiphenyl results in increased expression of GRM3 mRNA"	23829299
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GRM3 mRNA"	20816883
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRM3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRM3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRM3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRM3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRM3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRM3 mRNA"	27188386
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of GRM3 mRNA"	21346803
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRM3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRM3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRM3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRM3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRM3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRM3 mRNA"	27188386
D000111	Acetylcysteine	Acetylcysteine results in increased activity of GRM3 protein	19136971
D020106	Acrylamide	Acrylamide results in decreased expression of GRM3 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of GRM3 gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GRM3 mRNA	16483693
D001280	Atrazine	Atrazine results in decreased expression of GRM3 mRNA	25929836
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GRM3 mRNA	26001963
D004958	Estradiol	Estradiol results in increased activity of GRM3 protein	15901789
C006780	bisphenol A	bisphenol A results in decreased expression of GRM3 mRNA	25181051\|2581294
C006780	bisphenol A	bisphenol A results in increased expression of GRM3 mRNA	29097150
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of GRM3 protein	16845489
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRM3 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of GRM3 mRNA	26272509
D003042	Cocaine	Cocaine affects the expression of GRM3 protein	19105975
D003042	Cocaine	Cocaine results in increased activity of GRM3 protein	20416862
D003976	Diazinon	Diazinon results in decreased expression of GRM3 mRNA	19440498
D004159	Diphenylamine	GRM3 gene SNP affects the susceptibility to Diphenylamine analog	25622337
D000431	Ethanol	Ethanol results in decreased expression of GRM3 mRNA	20655511
D000431	Ethanol	"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of GRM3 mRNA]"	20655511
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of GRM3 mRNA	29097150
D011345	Fenofibrate	Fenofibrate results in increased expression of GRM3 mRNA	25572481
D019833	Genistein	[Genistein co-treated with Methoxychlor] results in decreased expression of GRM3 mRNA	21782745
C027172	isospaglumic acid	isospaglumic acid binds to and results in increased activity of GRM3 protein	19887067
D007649	Ketamine	Ketamine results in decreased expression of GRM3 mRNA	20080153
C114624	LY 341495	LY 341495 binds to and results in decreased activity of GRM3 protein	16675638
C114624	LY 341495	LY 341495 binds to and results in decreased activity of GRM3 protein	16000629\|1988706
C114624	LY 341495	LY 341495 results in decreased activity of GRM3 protein	16914679
C118218	LY 379268	LY 379268 binds to and results in increased activity of GRM3 protein	16675638
C118218	LY 379268	LY 379268 binds to and results in increased activity of GRM3 protein	15152032\|1689352
D008694	Methamphetamine	Methamphetamine results in decreased expression of GRM3 mRNA	15644446
D008694	Methamphetamine	Methamphetamine results in increased expression of GRM3 mRNA	18419818
D008731	Methoxychlor	[Genistein co-treated with Methoxychlor] results in decreased expression of GRM3 mRNA	21782745
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of GRM3 mRNA	28001369
C028007	nickel monoxide	nickel monoxide results in decreased expression of GRM3 mRNA	19167457
C520612	N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid	"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of GRM3 mRNA]"	20655511
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRM3 mRNA"	27188386
C496932	panobinostat	panobinostat results in decreased expression of GRM3 mRNA	26272509
C410127	PCB 180	PCB 180 results in increased expression of GRM3 mRNA	23829299
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRM3 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of GRM3 mRNA	26272509
D010862	Pilocarpine	Pilocarpine results in decreased expression of GRM3 mRNA	18585369\|1880409
D010862	Pilocarpine	Pilocarpine results in decreased expression of GRM3 protein	16793029\|1880409
D010936	Plant Extracts	Plant Extracts results in decreased expression of GRM3 mRNA	23557933
D014212	Tretinoin	Tretinoin results in decreased expression of GRM3 mRNA	21934132
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRM3 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of GRM3 mRNA	24935251\|2627250
C046488	trimethyltin	trimethyltin results in decreased expression of GRM3 mRNA	24002884
C057693	troglitazone	troglitazone results in increased expression of GRM3 mRNA	25572481
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRM3 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of GRM3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of GRM3 mRNA	26272509
D014635	Valproic Acid	Valproic Acid results in increased expression of GRM3 mRNA	23179753\|2718838
D014635	Valproic Acid	Valproic Acid affects the expression of GRM3 mRNA	17963808
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRM3 mRNA"	27188386
C111237	vorinostat	vorinostat results in decreased expression of GRM3 mRNA	26272509

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001641	group II metabotropic glutamate receptor activity	-	IEA	-
GO:0004930	G-protein coupled receptor activity	-	TAS	8840013
GO:0005246	calcium channel regulator activity	-	IEA	-
GO:0008066	glutamate receptor activity	-	IBA	21873635
GO:0008066	glutamate receptor activity	-	TAS	8840013

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007194	negative regulation of adenylate cyclase activity	-	TAS	8840013
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway	-	IEA	-
GO:0007216	G-protein coupled glutamate receptor signaling pathway	-	IBA	21873635
GO:0007268	chemical synaptic transmission	-	TAS	8840013
GO:0051966	regulation of synaptic transmission, glutamatergic	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	TAS	8840013
GO:0014069	postsynaptic density	-	IEA	-
GO:0030424	axon	-	IEA	-
GO:0042734	presynaptic membrane	-	IEA	-
GO:0043197	dendritic spine	-	IEA	-
GO:0045211	postsynaptic membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-420499	Class C/3 (Metabotropic glutamate/pheromone receptors)	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25262781	Expression of glutamatergic genes in healthy humans across 16 brain regions; altered expression in the hippocampus after chronic exposure to alcohol or cocaine. (2014 Nov)	Enoch MA	Genes Brain Behav
22511924	Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: functional and mechanistic implications. (2012)	Wolen AR	PLoS One
22909248	Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate levels and neurocognition in non-smoking, active alcoholics. (2012 Aug 21)	Xia Y	Behav Brain Funct
25046171	The functional GRM3 Kozak sequence variant rs148754219 affects the risk of schizophrenia and alcohol dependence as well as bipolar disorder. (2014 Dec)	O'Brien NL	Psychiatr Genet
24585043	Association of single-nucleotide polymorphisms in a metabotropic glutamate receptor GRM3 gene subunit to alcohol-dependent male subjects. (2014 May-Jun)	Xia Y	Alcohol Alcohol
24844177	Genetic risk prediction and neurobiological understanding of alcoholism. (2014 May 20)	Levey DF	Transl Psychiatry