Gene: LUZP2

338645
KFSP2566|PRO6246
leucine zipper protein 2
protein-coding
11p14.3
Ensembl:ENSG00000187398 MIM:608178 Vega:OTTHUMG00000166109 UniprotKB:Q86TE4
NG_030588.1
SNP Mapped
4   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.548e-1 (AD)  9.327e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10834489chr11:24816255 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs10834476chr11:24752960 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs11028019chr11:24562345 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs7927293chr11:24506412 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEMA5A0.778
LHFPL30.776
BCHE0.739
GRID20.708
PDGFRA0.707
BLM0.7
STK32A0.682
PCDH150.67
NXPH10.647
TMEM255A0.644

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.368
HSD11B2-0.317
OR4F29-0.309
MROH6-0.305
HES7-0.289
GPR35-0.287
GAS2L2-0.278
GPR55-0.275
NPC1L1-0.27
IL1RL1-0.269

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of LUZP2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LUZP2 mRNA22100608
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LUZP2 mRNA22228805
D003630DaunorubicinLUZP2 affects the susceptibility to Daunorubicin17545624
D016047Zalcitabine"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of LUZP2 mRNA"18606552
D002117CalcitriolCalcitriol results in decreased expression of LUZP2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of LUZP2 mRNA21592394
C514793gp120 protein, Human immunodeficiency virus 1"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of LUZP2 mRNA"18606552
D010069Oxadiazoles[Oxadiazoles analog co-treated with FGF2 protein] results in decreased expression of LUZP2 mRNA23212921
D011374ProgesteroneProgesterone results in decreased expression of LUZP2 mRNA19690047
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of LUZP2 mRNA25879800
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of LUZP2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of LUZP2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LUZP2 mRNA24680724
D001335Vehicle EmissionsVehicle Emissions affects the methylation of LUZP2 gene25560391
C025643vinclozolinvinclozolin affects the expression of LUZP2 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal