Gene: RYR3

6263
RYR-3
ryanodine receptor 3
protein-coding
15q13.3-q14
Ensembl:ENSG00000198838 MIM:180903 Vega:OTTHUMG00000172253 UniprotKB:Q15413
NG_047076.1
PubMed|SNP Mapped
6   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.862e-1 (AD)  4.627e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7172406chr15:33849304 (GRCh38.p7)G>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs1565937chr15:33603990 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs16973062chr15:33600096 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4144333chr15:33502351 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs2676029chr15:33430601 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs17236010chr15:33396486 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAPLN0.878
PRDM160.871
ATP13A40.87
DOCK70.866
ZNRF30.863
SPON10.846
NTRK20.843
SLC39A120.841
OPHN10.838
ELOVL20.837

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SULT2B1-0.39
SCARA5-0.353
GAL-0.351
QRFPR-0.342
TC2N-0.34
LGI2-0.333
GADL1-0.33
CRHBP-0.323
FER1L6-0.315
IBSP-0.31

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11093Calcium CitrateSmall Molecule813-94-5ApprovedTransporter
DB11348Calcium PhosphateSmall Molecule10103-46-5ApprovedTransporter
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RYR3 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of RYR3 mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA"27188386
C0051475'-adenylyl (beta,gamma-methylene)diphosphonate"5'-adenylyl (beta,gamma-methylene)diphosphonate affects the reaction [Dantrolene results in decreased activity of RYR3 protein]"11278295
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA"27188386
D020106AcrylamideAcrylamide affects the expression of RYR3 mRNA28606764
D001151ArsenicArsenic affects the methylation of RYR3 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of RYR3 protein15894607
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in increased expression of RYR3 protein15894607
C061387azumoleneazumolene results in decreased activity of RYR3 protein11278295
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of RYR3 gene25435355
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of RYR3 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of RYR3 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of RYR3 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of RYR3 mRNA22079614
D019256Cadmium ChlorideCadmium Chloride results in increased expression of RYR3 mRNA24982889
D002110CaffeineCaffeine results in decreased expression of RYR3 mRNA23774253
D002118CalciumCalcium affects the reaction [Dantrolene inhibits the reaction [Ryanodine binds to RYR3 protein]]11278295
D002118CalciumCalcium affects the reaction [Dantrolene results in decreased activity of RYR3 protein]11278295
D002220CarbamazepineCarbamazepine results in decreased expression of RYR3 mRNA23774253
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RYR3 mRNA12734012
D003042CocaineCocaine affects the expression of RYR3 mRNA20187946
D003471CuprizoneCuprizone results in decreased expression of RYR3 mRNA26577399
D003620Dantrolene"5'-adenylyl (beta,gamma-methylene)diphosphonate affects the reaction [Dantrolene results in decreased activity of RYR3 protein]"11278295
D003620DantroleneCalcium affects the reaction [Dantrolene inhibits the reaction [Ryanodine binds to RYR3 protein]]11278295
D003620DantroleneCalcium affects the reaction [Dantrolene results in decreased activity of RYR3 protein]11278295
D003620DantroleneDantrolene inhibits the reaction [Ryanodine binds to RYR3 protein]11278295
D003620DantroleneDantrolene results in decreased activity of RYR3 protein11278295
C118739entinostatentinostat results in decreased expression of RYR3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA"27188386
C069837fullerene C60fullerene C60 results in decreased expression of RYR3 mRNA19167457
C008261lead acetatelead acetate affects the expression of RYR3 mRNA21147602
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to RYR3 promoter]20348232
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RYR3 mRNA28001369
D009532NickelNickel results in decreased expression of RYR3 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in decreased expression of RYR3 mRNA19167457
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of RYR3 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of RYR3 mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in increased expression of RYR3 protein23718831
D011192Potassium DichromatePotassium Dichromate results in decreased expression of RYR3 mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of RYR3 mRNA20660070
C502851quinocetonequinocetone results in increased expression of RYR3 mRNA27046791
D012433RyanodineCalcium affects the reaction [Dantrolene inhibits the reaction [Ryanodine binds to RYR3 protein]]11278295
D012433RyanodineDantrolene inhibits the reaction [Ryanodine binds to RYR3 protein]11278295
D012433RyanodineRyanodine binds to RYR3 protein11278295
C017947sodium arsenitesodium arsenite affects the methylation of RYR3 gene28589171
D013749Tetrachlorodibenzodioxin[AHR protein affects the susceptibility to Tetrachlorodibenzodioxin] which affects the expression of RYR3 mRNA27163630
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of RYR3 mRNA25975270
D013849ThimerosalThimerosal results in increased expression of RYR3 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of RYR3 mRNA20133372
D014050TolueneToluene affects the expression of RYR3 mRNA21827849
D014212TretinoinTretinoin results in decreased expression of RYR3 mRNA23774253
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in increased expression of RYR3 protein15894607
D014212TretinoinTretinoin results in increased expression of RYR3 protein15894607
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of RYR3 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of RYR3 mRNA19042947
D014520UrethaneUrethane results in decreased expression of RYR3 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of RYR3 mRNA23774253
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of RYR3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of RYR3 mRNA23179753|2438349
C025643vinclozolinvinclozolin results in decreased expression of RYR3 mRNA23869203
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of RYR3 mRNA26272509|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005219ryanodine-sensitive calcium-release channel activity-IBA21873635  
GO:0005219ryanodine-sensitive calcium-release channel activity-ISS-  
GO:0005219ryanodine-sensitive calcium-release channel activity-TAS19095005  
GO:0005509calcium ion binding-IBA21873635  
GO:0005516calmodulin binding-IEA-  
GO:0015278calcium-release channel activity-IMP9395096  
GO:0048763calcium-induced calcium release activity-IBA21873635  
GO:0048763calcium-induced calcium release activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006816calcium ion transport-IMP9395096  
GO:0034220ion transmembrane transport-TAS-  
GO:0051209release of sequestered calcium ion into cytosol-IBA21873635  
GO:0051209release of sequestered calcium ion into cytosol-IEA-  
GO:0051289protein homotetramerization-ISS-  
GO:0051481negative regulation of cytosolic calcium ion concentration-IEA-  
GO:0070588calcium ion transmembrane transport-ISS-  
GO:0071277cellular response to calcium ion-ISS-  
GO:0071286cellular response to magnesium ion-ISS-  
GO:0071313cellular response to caffeine-ISS-  
GO:0071318cellular response to ATP-ISS-  
GO:1903779regulation of cardiac conduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005790smooth endoplasmic reticulum-IBA21873635  
GO:0005886plasma membrane-IBA21873635  
GO:0016021integral component of membrane-ISS-  
GO:0016529sarcoplasmic reticulum-ISS-  
GO:0030018Z disc-IBA21873635  
GO:0030659cytoplasmic vesicle membrane-IBA21873635  
GO:0033017sarcoplasmic reticulum membrane-IBA21873635  
GO:0033017sarcoplasmic reticulum membrane-ISS-  
GO:0033017sarcoplasmic reticulum membrane-TAS-  
GO:0034704calcium channel complex-IBA21873635  
GO:0042383sarcolemma-IBA21873635  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04970Salivary secretion
hsa05010Alzheimer's disease
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-397014Muscle contractionTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578775Ion homeostasisTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28226201Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms. (2017 May)Adkins AEAlcohol Clin Exp Res
21970977Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia. (2012 Feb)Stephens SHPsychiatr Genet