Gene: SNX16

64089
-
sorting nexin 16
protein-coding
8q21.13
Ensembl:ENSG00000104497 MIM:614903 Vega:OTTHUMG00000164727 UniprotKB:P57768
NC_000008.11
SNP Mapped
9   ANCO-SNPs
AD
0   
5.027e-1 (AD)  8.423e-1 (ND)   (Frontal_Cortex)
3.376e-2 (AD)  4.734e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1451995chr8:81833888 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4739627chr8:81822422 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs12544174chr8:81819242 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs13255262chr8:81815789 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs6473311chr8:81814447 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7825180chr8:81811756 (GRCh38.p7)T>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs10958045chr8:81810759 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs7846521chr8:81805872 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs1054078chr8:81799918 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07697082chr8:82753677SNX16Promoter4.124e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPS20.82
ZNF6540.807
UHMK10.804
TMTC30.801
DNAAF20.8
BUB30.799
PPP4R20.793
CGGBP10.793
RAB8B0.791
ETNK10.789

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.454
OR4F29-0.423
ASB4-0.338
NXNL1-0.308
ACOX2-0.289
HKDC1-0.289
CYP11A1-0.287
GLI1-0.286
COX4I2-0.282
HES5-0.279

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in increased expression of SNX16 mRNA"22101062
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of SNX16 mRNA"20453058
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SNX16 mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of SNX16 mRNA"23146750
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SNX16 mRNA"21346803
C0212962-ethoxyethanol2-ethoxyethanol results in increased expression of SNX16 mRNA19643169
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SNX16 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SNX16 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SNX16 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SNX16 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SNX16 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SNX16 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of SNX16 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of SNX16 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SNX16 mRNA20064835
C006780bisphenol Abisphenol A results in decreased expression of SNX16 mRNA23146750
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SNX16 mRNA27339419
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of SNX16 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of SNX16 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of SNX16 mRNA20106945|2556210
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SNX16 mRNA23640034
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of SNX16 mRNA"23811387
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SNX16 mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SNX16 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of SNX16 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of SNX16 mRNA23649840
C544151jinfukangjinfukang results in decreased expression of SNX16 mRNA27392435
D007649KetamineKetamine results in decreased expression of SNX16 mRNA20080153
C045463leflunomideleflunomide results in increased expression of SNX16 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of SNX16 mRNA"24972896
C005219methyl cellosolvemethyl cellosolve results in increased expression of SNX16 mRNA19643169
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SNX16 mRNA23458150
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SNX16 mRNA23649840
C523184mocetinostatmocetinostat results in increased expression of SNX16 mRNA27255383
C028473N-acetyl-4-benzoquinoneimineSNX16 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine21177773
D009285NaphthoquinonesNaphthoquinones results in increased expression of SNX16 mRNA23811387
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of SNX16 mRNA17616710
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of SNX16 mRNA20971185
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SNX16 mRNA27153767
D010634PhenobarbitalPhenobarbital affects the expression of SNX16 mRNA19159669
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of SNX16 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of SNX16 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of SNX16 mRNA19482888
D012834SilverSilver results in increased expression of SNX16 mRNA26014281
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of SNX16 mRNA"26680231
D013629TamoxifenTamoxifen affects the expression of SNX16 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SNX16 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SNX16 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SNX16 mRNA17942748
D013792ThalidomideThalidomide analog results in increased expression of SNX16 mRNA20525221
D013853ThioacetamideThioacetamide results in increased expression of SNX16 mRNA23411599
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SNX16 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of SNX16 mRNA26272509
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SNX16 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of SNX16 mRNA28973697
D014520UrethaneUrethane results in increased expression of SNX16 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of SNX16 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SNX16 mRNA24935251|2915479
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SNX16 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of SNX16 mRNA20566332

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0035091phosphatidylinositol binding-IDA12813048  
GO:0042802identical protein binding-IPI12813048  
GO ID GO Term Qualifier Evidence PubMed
GO:0006622protein targeting to lysosome-IMP12813048  
GO:0008333endosome to lysosome transport-IMP12813048  
GO:0032780negative regulation of ATPase activity-IBA21873635  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0043271negative regulation of ion transport-IBA21873635  
GO:0045022early endosome to late endosome transport-IMP12813048  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005764lysosome-IEA-  
GO:0005769early endosome-IDA12813048  
GO:0005770late endosome-IDA12813048  
GO:0005829cytosol-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0031313extrinsic component of endosome membrane-IDA12813048  
GO:0031901early endosome membrane-IEA-  
GO:0031902late endosome membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal