Gene: ZNF224

7767
BMZF-2|BMZF2|KOX22|ZNF233|ZNF255|ZNF27
zinc finger protein 224
protein-coding
19q13.31
Ensembl:ENSG00000267680 MIM:194555 Vega:OTTHUMG00000182313 UniprotKB:Q9NZL3
NG_051221.1
SNP Mapped
38   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.661e-1 (AD)  6.549e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2061333chr19:44110055 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2061332chr19:44109508 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6509141chr19:44108966 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3746319chr19:44108078 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs3200505chr19:44107861 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3746321chr19:44107852 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs4508518chr19:44107267 (GRCh38.p7)A>G / A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4239529chr19:44106645 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2068061chr19:44106512 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7250171chr19:44106152 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs7250076chr19:44106142 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7249834chr19:44105942 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7249827chr19:44105876 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs3172chr19:44105693 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)
rs8101657chr19:44105571 (GRCh38.p7)T>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs4803681chr19:44105332 (GRCh38.p7)G>A / G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4803680chr19:44105140 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4803679chr19:44105007 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4803678chr19:44104994 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4803677chr19:44104810 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs8113750chr19:44104636 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10420143chr19:44103929 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs28446946chr19:44103466 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs28539456chr19:44103394 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs8105860chr19:44102775 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs4803676chr19:44100970 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs62115526chr19:44100761 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs8108404chr19:44099822 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs8104573chr19:44099232 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7250004chr19:44098839 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7250005chr19:44098806 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10410306chr19:44097384 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4802207chr19:44096224 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4802206chr19:44096083 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4459653chr19:44095462 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4429390chr19:44094715 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs4802205chr19:44093276 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs4802204chr19:44093142 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF4400.859
TAF10.844
ATXN70.842
MASP20.842
RNPC30.84
GPATCH80.832
USP490.828
TSTD20.826
CHD60.823
NFATC2IP0.822

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.396
BCL7C-0.382
PLA2G5-0.378
AQP5-0.376
LYPD1-0.376
RBP1-0.372
SLC22A6-0.365
S100A14-0.352
HMX1-0.326
VAX2-0.32

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF224 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF224 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ZNF224 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ZNF224 gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of ZNF224 mRNA21757418
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in decreased expression of ZNF224 protein15894607
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ZNF224 mRNA22316170
C006780bisphenol Abisphenol A results in increased expression of ZNF224 mRNA29275510
C515564bromovaninbromovanin results in increased expression of ZNF224 protein21419150
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ZNF224 mRNA26314618
D019327Copper SulfateCopper Sulfate results in increased expression of ZNF224 mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of ZNF224 mRNA22077320
D016572CyclosporineCyclosporine results in decreased expression of ZNF224 mRNA25562108
D004726EndosulfanEndosulfan results in decreased expression of ZNF224 protein26722802
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of ZNF224 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of ZNF224 mRNA20655997
D008345ManganeseManganese results in increased expression of ZNF224 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of ZNF224 mRNA17175027
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ZNF224 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ZNF224 mRNA23649840
D010100OxygenOxygen deficiency results in increased expression of ZNF224 mRNA17175027
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ZNF224 mRNA27153767
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF224 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ZNF224 mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of ZNF224 mRNA23557933
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ZNF224 mRNA23806026
D018038Sodium SeleniteSodium Selenite results in decreased expression of ZNF224 mRNA18175754
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ZNF224 mRNA28065790
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in decreased expression of ZNF224 protein15894607
D014212TretinoinTretinoin results in decreased expression of ZNF224 protein15894607
C012589trichostatin Atrichostatin A results in increased expression of ZNF224 mRNA24935251
D014520UrethaneUrethane results in increased expression of ZNF224 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of ZNF224 mRNA28001369

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA12527367  
GO:0005515protein binding-IPI20587513  
GO:0043565sequence-specific DNA binding-IDA12527367  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA12527367  
GO:0006351transcription, DNA-templated-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IDA20587513  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA20587513  23665872  
GO:0017053transcriptional repressor complex-IDA20587513  
GO:0031965nuclear membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal