| SNP ID | Position | Alleles | Trait | Variation Type |
|---|---|---|---|---|
| rs16953047 | chr16:54096258 (GRCh38.p7) | G>T | alcohol dependence | SNV(Single Nucleotide Variation) |
| rs16952906 | chr16:54049255 (GRCh38.p7) | T>C | nicotine dependence | SNV(Single Nucleotide Variation) |
| rs2302673 | chr16:54034209 (GRCh38.p7) | T>C | nicotine dependence | SNV(Single Nucleotide Variation) |
| rs13331869 | chr16:54032082 (GRCh38.p7) | T>A | nicotine dependence | SNV(Single Nucleotide Variation) |
| rs1362571 | chr16:53877858 (GRCh38.p7) | G>A / G>T | alcohol dependence | SNV(Single Nucleotide Variation) |
| rs10521308 | chr16:53831214 (GRCh38.p7) | G>A | nicotine dependence | SNV(Single Nucleotide Variation) |
| Probe | Locus(GRCh37) | Gene | Region | p-val | Trait | PubMed ID |
| cg26580413 | chr16:54025348 | FTO | 1.020e-8 | Maternal smoking in pregnancy | 27040690 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| FBXO11 | 0.942 |
| IDH3A | 0.939 |
| PITPNB | 0.936 |
| NEU3 | 0.935 |
| SLC12A6 | 0.935 |
| USP32 | 0.935 |
| CDKL2 | 0.933 |
| SMAP1 | 0.932 |
| UBE4A | 0.922 |
| MTPN | 0.921 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| S100A1 | -0.444 |
| RAB13 | -0.438 |
| ROM1 | -0.428 |
| BCL7C | -0.423 |
| AKR1C3 | -0.418 |
| CSAG1 | -0.413 |
| HIST1H1C | -0.402 |
| COPZ2 | -0.4 |
| RARRES2 | -0.399 |
| PPP1R14B | -0.399 |
| ID | Drug Name | Drug Type | CAS Num | Status | Role |
|---|---|---|---|---|---|
| DB11638 | Artenimol | Small Molecule | 71939-50-9 | Approved|Investigational | Target |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| D016604 | Aflatoxin B1 | Aflatoxin B1 affects the expression of FTO protein | 20106945 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased methylation of FTO gene | 27153756 |
| D018501 | Antirheumatic Agents | Antirheumatic Agents results in increased expression of FTO mRNA | 24449571 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of FTO mRNA | 20106945|2163298 |
| D015123 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | "7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FTO mRNA" | 26238291 |
| C006780 | bisphenol A | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FTO mRNA | 28628672 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of FTO mRNA | 26063408 |
| C006780 | bisphenol A | bisphenol A results in increased expression of FTO mRNA | 26063408 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of FTO mRNA | 25181051 |
| C006780 | bisphenol A | bisphenol A results in increased methylation of FTO gene | 28505145 |
| C000611646 | bisphenol F | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FTO mRNA | 28628672 |
| C018475 | butyraldehyde | butyraldehyde results in decreased expression of FTO mRNA | 26079696 |
| D003907 | Dexamethasone | Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of FTO mRNA] | 27941970 |
| D003907 | Dexamethasone | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FTO mRNA | 28628672 |
| D003907 | Dexamethasone | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FTO mRNA | 28628672 |
| D002945 | Cisplatin | Cisplatin results in decreased expression of FTO mRNA | 19561079|2759478 |
| C000944 | dicrotophos | dicrotophos results in increased expression of FTO mRNA | 28302478 |
| D004041 | Dietary Fats | FTO polymorphism affects the susceptibility to Dietary Fats | 21798115 |
| D004041 | Dietary Fats | Dietary Fats results in decreased expression of FTO mRNA | 18042831 |
| C039060 | dihydroartemisinin | dihydroartemisinin analog binds to FTO protein | 26340163 |
| D004791 | Enzyme Inhibitors | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of FTO protein | 23301498 |
| D005557 | Formaldehyde | Formaldehyde results in decreased expression of FTO mRNA | 23649840 |
| D007213 | Indomethacin | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FTO mRNA | 28628672 |
| D007213 | Indomethacin | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FTO mRNA | 28628672 |
| D007213 | Indomethacin | Indomethacin results in increased expression of FTO mRNA | 28201806 |
| C051890 | irinotecan | irinotecan analog results in decreased expression of FTO mRNA | 18927307 |
| D015056 | 1-Methyl-3-isobutylxanthine | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FTO mRNA | 28628672 |
| D015056 | 1-Methyl-3-isobutylxanthine | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FTO mRNA | 28628672 |
| D007854 | Lead | Lead results in decreased expression of FTO mRNA | 19921347 |
| D008741 | Methyl Methanesulfonate | Methyl Methanesulfonate results in decreased expression of FTO mRNA | 26011545 |
| D018817 | N-Methyl-3,4-methylenedioxyamphetamine | "N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of FTO mRNA" | 20188158 |
| C030110 | oxaliplatin | [oxaliplatin co-treated with Topotecan] results in decreased expression of FTO mRNA | 25729387 |
| D000073878 | Palm Oil | Palm Oil results in decreased expression of FTO mRNA | 18042831 |
| C046012 | pentanal | pentanal results in decreased expression of FTO mRNA | 26079696 |
| C009277 | sodium arsenate | sodium arsenate results in increased expression of FTO mRNA | 21795629 |
| D012969 | Sodium Fluoride | Sodium Fluoride results in increased expression of FTO protein | 28918527 |
| D012999 | Soman | Soman results in decreased expression of FTO mRNA | 19281266 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin affects the expression of FTO mRNA | 21570461 |
| D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution results in increased expression of FTO mRNA | 28065790 |
| D019772 | Topotecan | [oxaliplatin co-treated with Topotecan] results in decreased expression of FTO mRNA | 25729387 |
| D014635 | Valproic Acid | Valproic Acid affects the expression of FTO mRNA | 25979313 |
| D014635 | Valproic Acid | Valproic Acid results in decreased methylation of FTO gene | 29154799 |
| D014635 | Valproic Acid | Valproic Acid results in increased expression of FTO mRNA | 23179753|2718838 |
| D014638 | Vanadates | Vanadates results in increased expression of FTO mRNA | 22714537 |
| D015034 | Zinc Oxide | Zinc Oxide analog results in increased expression of FTO mRNA | 27215404 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0008198 | ferrous iron binding | - | IDA | 20376003 |
| GO:0035515 | oxidative RNA demethylase activity | - | IDA | 18775698 22002720 |
| GO:0035515 | oxidative RNA demethylase activity | - | TAS | - |
| GO:0035516 | oxidative DNA demethylase activity | - | IDA | 18775698 20376003 |
| GO:0043734 | DNA-N1-methyladenine dioxygenase activity | - | IDA | 20376003 |
| GO:1990931 | RNA N6-methyladenosine dioxygenase activity | - | IMP | 26458103 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0001659 | temperature homeostasis | - | IEA | - |
| GO:0006307 | DNA dealkylation involved in DNA repair | - | IDA | 18775698 20376003 |
| GO:0006307 | DNA dealkylation involved in DNA repair | - | TAS | - |
| GO:0010883 | regulation of lipid storage | - | IMP | 26287746 |
| GO:0035552 | oxidative single-stranded DNA demethylation | - | IDA | 18775698 20376003 |
| GO:0035553 | oxidative single-stranded RNA demethylation | - | IDA | 18775698 22002720 |
| GO:0035553 | oxidative single-stranded RNA demethylation | - | IMP | 26458103 |
| GO:0040014 | regulation of multicellular organism growth | - | IEA | - |
| GO:0042245 | RNA repair | - | IDA | 18775698 |
| GO:0044065 | regulation of respiratory system process | - | IEA | - |
| GO:0060612 | adipose tissue development | - | IEA | - |
| GO:0070350 | regulation of white fat cell proliferation | - | IEA | - |
| GO:0070989 | oxidative demethylation | - | IDA | 18775698 |
| GO:0080111 | DNA demethylation | - | IDA | 18775698 |
| GO:0090335 | regulation of brown fat cell differentiation | - | IMP | 26287746 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005634 | nucleus | - | IDA | 26458103 |
| GO:0005634 | nucleus | - | ISS | 17991826 |
| GO:0005654 | nucleoplasm | - | TAS | - |
| GO:0016607 | nuclear speck | - | IDA | 22002720 |
| KEGG ID | KEGG Term |
|---|
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-HSA-73894 | DNA Repair | TAS |
| R-HSA-73942 | DNA Damage Reversal | TAS |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | TAS |
| PMID | Title (Year) | Author | Journal |
|---|---|---|---|
| 25101807 | Fat mass and obesity-associated obesity-risk genotype is associated with lower foetal growth: an effect that is reversed in the offspring of smoking mothers. (2012 Feb) | Marsh JA | J Dev Orig Health Dis |
| 21357378 | Body mass index and obesity- and diabetes-associated genotypes and risk for pancreatic cancer. (2011 May) | Tang H | Cancer Epidemiol Biomarkers Prev |
| 22235250 | Quantile-specific penetrance of genes affecting lipoproteins, adiposity and height. (2012) | Williams PT | PLoS One |
| 18833210 | The FTO gene and obesity in a large Eastern European population sample: the HAPIEE study. (2008 Dec) | Hubacek JA | Obesity (Silver Spring) |
| 25510251 | GNB3 and FTO Polymorphisms and Pregnancy Weight Gain in Black Women. (2015 Jul) | Groth SW | Biol Res Nurs |
| 25916125 | [Pancreatitis, pancreatic cancer and obesity: hypothesis and facts]. (2014) | Grigor'eva IN | Eksp Klin Gastroenterol |
| 27146691 | Risk of obesity and metabolic syndrome associated with FTO gene variants discloses clinically relevant gender difference among Turks. (2016 Jun) | Guclu-Geyik F | Mol Biol Rep |
| 19214238 | Fatness-associated FTO gene variant increases mortality independent of fatness--in cohorts of Danish men. (2009) | Zimmermann E | PLoS One |
| 18317470 | NYD-SP18 is associated with obesity in the NHLBI Family Heart Study. (2008 Jun) | Wilk JB | Int J Obes (Lond) |
| 23784909 | Risk factors and outcomes of maternal obesity and excessive weight gain during pregnancy. (2013 May) | Gaillard R | Obesity (Silver Spring) |
| 29375034 | Diet/lifestyle and risk of diabetes and glycemic traits: a Mendelian randomization study. (2018 Jan 29) | Ding R | Lipids Health Dis |
| 21989907 | Association of the FTO rs9939609 polymorphism with obesity in Roma/Gypsy population. (2012 Jan) | Macekova S | Am J Phys Anthropol |
| 25014319 | Candidate gene study for smoking, alcohol use, and body weight in a sample of pregnant women. (2015 May) | Wehby GL | J Matern Fetal Neonatal Med |
| 28167353 | Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants. (2017 Mar) | Shahid SU | Atherosclerosis |
| 23701534 | Genetic instrumental variable studies of effects of prenatal risk factors. (2013) | Wehby GL | Biodemography Soc Biol |
| 22157232 | Lack of an association between three tagging SNPs within the FTO gene and smoking behavior. (2012 Aug) | Hubacek JA | Nicotine Tob Res |
| 26555680 | The fat mass and obesity-associated (FTO) gene variant rs9939609 predicts long-term incidence of cardiovascular disease and related death independent of the traditional risk factors. (2015) | Aijala M | Ann Med |
| 23978819 | Generalization of adiposity genetic loci to US Hispanic women. (2013 Aug 26) | Graff M | Nutr Diabetes |
| 23835106 | Association between variations in the fat mass and obesity-associated gene and pancreatic cancer risk: a case-control study in Japan. (2013 Jul 8) | Lin Y | BMC Cancer |
| 23771786 | Genetic variants in the fat mass- and obesity-associated (FTO) gene are associated with alcohol dependence. (2013 Oct) | Wang L | J Mol Neurosci |
| 27905213 | Hepatic, lipid and genetic factors associated with obesity: crosstalk with alcohol dependence? (2017 Mar) | Goodyear K | World J Biol Psychiatry |
| 23512716 | Association between obesity-related gene FTO and ADHD. (2013 Dec) | Choudhry Z | Obesity (Silver Spring) |
| 24532085 | The fat mass and obesity-associated FTO rs9939609 polymorphism is associated with elevated homocysteine levels in patients with multiple sclerosis screened for vascular risk factors. (2014 Jun) | Davis W | Metab Brain Dis |
| 19020324 | Clinical risk factors, DNA variants, and the development of type 2 diabetes. (2008 Nov 20) | Lyssenko V | N Engl J Med |
| 26105235 | OS021. Risk factors and outcomes of maternal obesity and excessive weight gain during pregnancy. (2012 Jul) | Gaillard R | Pregnancy Hypertens |
| 25265168 | Inverse association between obesity predisposing FTO genotype and completed suicide. (2014) | Chojnicka I | PLoS One |
| 28384342 | Assessing gene-environment interaction effects of FTO, MC4R and lifestyle factors on obesity using an extreme phenotype sampling design: Results from the HUNT study. (2017) | Bjornland T | PLoS One |
| 23311614 | Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study. (2013 Jan 11) | Fesinmeyer MD | BMC Med Genet |
| 21182554 | Inverse association of the obesity predisposing FTO rs9939609 genotype with alcohol consumption and risk for alcohol dependence. (2011 Apr) | Sobczyk-Kopciol A | Addiction |
| 19329528 | Relation of age-related cataract with obesity and obesity genes in an Asian population. (2009 May 15) | Lim LS | Am J Epidemiol |
| 25155933 | Familial risk for alcohol dependence and developmental changes in BMI: the moderating influence of addiction and obesity genes. (2014 Jul) | Lichenstein SD | Pharmacogenomics |
| 22413044 | Interactions between the FTO rs9939609 polymorphism, body mass index, and lifestyle-related factors on metabolic syndrome risk. (2012 Feb) | Baik I | Nutr Res Pract |
| 27701175 | Evaluation of the Obesity Genes FTO and MC4R for Contribution to the Risk of Large Artery Atherosclerotic Stroke in a Chinese Population. (2016) | Song Z | Obes Facts |
| 29469022 | Obesity candidate genes, gestational weight gain, and body weight changes in pregnant women. (2018 Apr) | Groth SW | Nutrition |
| 20031593 | The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: a Genetics of Diabetes Audit and Research Study in Tayside Scotland (Go-DARTS) study. (2009 Jun) | Doney AS | Circ Cardiovasc Genet |
| 22829130 | Direct genetic effects and their estimation from matched case-control data. (2012 Sep) | Berzuini C | Genet Epidemiol |
| 18599522 | FTO variants are associated with obesity in the Chinese and Malay populations in Singapore. (2008 Oct) | Tan JT | Diabetes |