Gene: SLC37A3

84255
-
solute carrier family 37 member 3
protein-coding
7q34
Ensembl:ENSG00000157800 Vega:OTTHUMG00000157343 UniprotKB:Q8NCC5
NC_000007.14
SNP Mapped
5   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.152e-1 (AD)  4.049e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9640467chr7:140396403 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs9640465chr7:140396357 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6947516chr7:140380048 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs6955063chr7:140377628 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs7777468chr7:140371515 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRAPPC110.93
TMX30.929
PRKCI0.918
KPNA10.917
ATR0.916
PPIP5K20.916
SLC25A320.916
TCERG10.915
RINT10.914
TAB30.911

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.481
OR4F29-0.441
FXYD3-0.396
WDR38-0.357
FOXJ1-0.355
EVC2-0.354
S100A1-0.35
MTRNR2L6-0.349
EYA2-0.346
AKR1C3-0.345

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of SLC37A3 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of SLC37A3 mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SLC37A3 mRNA24449571
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of SLC37A3 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of SLC37A3 mRNA26496021
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SLC37A3 mRNA17484886
D003300CopperCopper results in increased expression of SLC37A3 mRNA16629173
D016572CyclosporineCyclosporine results in increased expression of SLC37A3 mRNA25562108
C000944dicrotophosdicrotophos results in decreased expression of SLC37A3 mRNA28302478
D004178DiquatDiquat affects the expression of SLC37A3 mRNA22814884
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of SLC37A3 mRNA"23811387
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of SLC37A3 mRNA22634610
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of SLC37A3 mRNA26846883
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of SLC37A3 mRNA"24972896
D009285NaphthoquinonesNaphthoquinones results in increased expression of SLC37A3 mRNA23811387
C029938nickel sulfatenickel sulfate results in decreased expression of SLC37A3 mRNA22714537
D010936Plant ExtractsPlant Extracts results in increased expression of SLC37A3 mRNA23557933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0061513glucose 6-phosphate:inorganic phosphate antiporter activityNOTIDA21949678  
GO ID GO Term Qualifier Evidence PubMed
GO:0008643carbohydrate transport-IEA-  
GO:0015760glucose-6-phosphate transportNOTIDA21949678  
GO:0035435phosphate ion transmembrane transportNOTIDA21949678  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0030176integral component of endoplasmic reticulum membrane-IDA21949678  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal