Gene: DCAF1

9730
RIP|VPRBP
DDB1 and CUL4 associated factor 1
protein-coding
3p21.2
Ensembl:ENSG00000145041 MIM:617259 Vega:OTTHUMG00000156895 UniprotKB:Q9Y4B6
NC_000003.12
SNP Mapped
7   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.602e-1 (AD)  6.853e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3762714chr3:51483637 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs4687610chr3:51449194 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs17712228chr3:51440166 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs3749317chr3:51419581 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2356261chr3:51407713 (GRCh38.p7)C>A / C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10510758chr3:51404233 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs3792408chr3:51400166 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of DCAF1 mRNA"20816883
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DCAF1 mRNA22316170
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DCAF1 mRNA"19150397
C006780bisphenol Abisphenol A results in decreased expression of DCAF1 mRNA26982218
C018475butyraldehydebutyraldehyde results in decreased expression of DCAF1 mRNA26079696
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DCAF1 mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of DCAF1 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of DCAF1 mRNA19167457
D008727MethotrexateMethotrexate results in decreased expression of DCAF1 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DCAF1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of DCAF1 mRNA"26251327
C046012pentanalpentanal results in decreased expression of DCAF1 mRNA26079696
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DCAF1 mRNA22574217
D014635Valproic AcidValproic Acid results in decreased expression of DCAF1 mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DCAF1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16949367  19264781  20178741  22157821  22190034  24336198  
24412650  25026211  
GO:0005524ATP binding-IEA-  
GO:0030331estrogen receptor binding-IBA21873635  
GO:0030331estrogen receptor binding-IPI28068668  
GO:1990244histone kinase activity (H2A-T120 specific)-IBA21873635  
GO:1990244histone kinase activity (H2A-T120 specific)-IDA24140421  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA24140421  
GO:0006351transcription, DNA-templated-IEA-  
GO:0016032viral process-IEA-  
GO:0016567protein ubiquitination-IEA-  
GO:0030183B cell differentiation-ISS-  
GO:0033151V(D)J recombination-ISS-  
GO:0035212cell competition in a multicellular organism-IMP20644714  
GO:1990245histone H2A-T120 phosphorylation-IBA21873635  
GO:1990245histone H2A-T120 phosphorylation-IDA24140421  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA20178741  
GO:0005737cytoplasm-IEA-  
GO:0008180COP9 signalosomecolocalizes_withIDA18850735  
GO:0080008Cul4-RING E3 ubiquitin ligase complex-IBA21873635  
GO:0080008Cul4-RING E3 ubiquitin ligase complex-IDA16949367  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal