DegronMD

Uniprot ID: A6NHP3

Source protein: Speedy protein E2B

Source gene: SPDYE2B

Class: DEG_ODPH_VHL_1

Location: 86:98

E3 ligase: VHL

DEGRON score: 0.9787

ASA_SCORE: 77.6615

COIL: 0.6176

CONS_SCORE: 0.6121

DSS_SCORE: 0.4331

HELIX: 0.2244

FCONS_SCORE: 1.4115

RIG_SCORE: 0.7882

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A87V	DO229213	THCA	ICGC	LAPEPEETWVVEM	DEG_ODPH_VHL_1	0.6936
p.D78E	DBTRG-05MG	central_nervous_system	COSMIC	LAPEPEETWVVEM	DEG_ODPH_VHL_1	0.1111
p.D78E	A431	skin	COSMIC	LAPEPEETWVVEM	DEG_ODPH_VHL_1	0.1111
p.D78E	RXF393	kidney	COSMIC	LAPEPEETWVVEM	DEG_ODPH_VHL_1	0.1111
p.D78E	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	LAPEPEETWVVEM	DEG_ODPH_VHL_1	0.1111
p.D78E	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	LAPEPEETWVVEM	DEG_ODPH_VHL_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NHP3	Speedy protein E2B	DEG_ODPH_VHL_1	86:98	LAPEPEETWVVEM	VHL	0.9787	More...
A6NIY4	Speedy protein E5	DEG_ODPH_VHL_1	86:98	LAPEPEETWVVEM	VHL	0.9466	More...
P0CI01	Speedy protein E6	DEG_ODPH_VHL_1	86:98	LAPEPEETWVVEM	VHL	0.9765	More...
Q495Y8	Speedy protein E2	DEG_ODPH_VHL_1	86:98	LAPEPEETWVVEM	VHL	0.9791	More...
A6NJR5	Putative speedy protein-like protein 3	DEG_ODPH_VHL_1	46:58	LAPEPEETWVVEM	VHL	0.8647	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons