DegronMD

Uniprot ID: A6NIY4

Source protein: Speedy protein E5

Source gene: SPDYE5

Class: DEG_ODPH_VHL_1

Location: 86:98

E3 ligase: VHL

DEGRON score: 0.9466

ASA_SCORE: 78.8692

COIL: 0.6252

CONS_SCORE: 0.3941

DSS_SCORE: 0.4125

HELIX: 0.2171

FCONS_SCORE: 1.0832

RIG_SCORE: 0.7882

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P82T	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	LAPEPEETWVVEM	DEG_ODPH_VHL_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NHP3	Speedy protein E2B	DEG_ODPH_VHL_1	86:98	LAPEPEETWVVEM	VHL	0.9787	More...
A6NIY4	Speedy protein E5	DEG_ODPH_VHL_1	86:98	LAPEPEETWVVEM	VHL	0.9466	More...
P0CI01	Speedy protein E6	DEG_ODPH_VHL_1	86:98	LAPEPEETWVVEM	VHL	0.9765	More...
Q495Y8	Speedy protein E2	DEG_ODPH_VHL_1	86:98	LAPEPEETWVVEM	VHL	0.9791	More...
A6NJR5	Putative speedy protein-like protein 3	DEG_ODPH_VHL_1	46:58	LAPEPEETWVVEM	VHL	0.8647	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons