DegronMD

Uniprot ID: Q495Y8

Source protein: Speedy protein E2

Source gene: SPDYE2

Class: DEG_ODPH_VHL_1

Location: 86:98

E3 ligase: VHL

DEGRON score: 0.9791

ASA_SCORE: 78.3

COIL: 0.6215

CONS_SCORE: 0.6542

DSS_SCORE: 0.4348

HELIX: 0.2105

FCONS_SCORE: 1.421

RIG_SCORE: 0.7829

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S78Y	TCGA-2W-A8YY	CESC	TCGA	LAPEPEETWVVEM	DEG_ODPH_VHL_1	0.1111
p.S78Y	SIDM01943	Colorectal Carcinoma	GDSC	LAPEPEETWVVEM	DEG_ODPH_VHL_1	0.1111
p.L86I	TCGA-AP-A051	UCEC	TCGA	LAPEPEETWVVEM	DEG_ODPH_VHL_1	0.6063
p.L86I	DO42673	UCEC	ICGC	LAPEPEETWVVEM	DEG_ODPH_VHL_1	0.6063
p.A87T	TCGA-EA-A3HU	CESC	TCGA	LAPEPEETWVVEM	DEG_ODPH_VHL_1	0.7139
p.A87T	DO6320	CESC	ICGC	LAPEPEETWVVEM	DEG_ODPH_VHL_1	0.7139
p.E92D	TCGA-EO-A3B0	UCEC	TCGA	LAPEPEETWVVEM	DEG_ODPH_VHL_1	0.5647
p.E92D	DO219773	UCEC	ICGC	LAPEPEETWVVEM	DEG_ODPH_VHL_1	0.5647
p.E91Q	TCGA-VS-A9UZ	CESC	TCGA	LAPEPEETWVVEM	DEG_ODPH_VHL_1	0.5633
p.E91Q	DO51646	CESC	ICGC	LAPEPEETWVVEM	DEG_ODPH_VHL_1	0.5633
p.K107R	DO227477	LAML	ICGC	LAPEPEETWVVEM	DEG_ODPH_VHL_1	0.1944
p.K107R	DO224558	LUSC	ICGC	LAPEPEETWVVEM	DEG_ODPH_VHL_1	0.1944
p.V96A	DO229058	LICA	ICGC	LAPEPEETWVVEM	DEG_ODPH_VHL_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NHP3	Speedy protein E2B	DEG_ODPH_VHL_1	86:98	LAPEPEETWVVEM	VHL	0.9787	More...
A6NIY4	Speedy protein E5	DEG_ODPH_VHL_1	86:98	LAPEPEETWVVEM	VHL	0.9466	More...
P0CI01	Speedy protein E6	DEG_ODPH_VHL_1	86:98	LAPEPEETWVVEM	VHL	0.9765	More...
Q495Y8	Speedy protein E2	DEG_ODPH_VHL_1	86:98	LAPEPEETWVVEM	VHL	0.9791	More...
A6NJR5	Putative speedy protein-like protein 3	DEG_ODPH_VHL_1	46:58	LAPEPEETWVVEM	VHL	0.8647	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons