DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LAPEPEETWVVEM
Uniprot ID:
P0CI01
Source protein:
Speedy protein E6
Source gene:
SPDYE6
Class:
DEG_ODPH_VHL_1
Location:
86:98
E3 ligase:
VHL
DEGRON score:
0.9765
ASA_SCORE:
79.9154
COIL:
0.5494
CONS_SCORE:
0.6121
DSS_SCORE:
0.4331
HELIX:
0.3593
FCONS_SCORE:
1.4115
RIG_SCORE:
0.7882
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with SPDYE6 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LAPEPEETWVVEM
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NHP3
Speedy protein E2B
DEG_ODPH_VHL_1
86:98
LAPEPEETWVVEM
VHL
0.9787
More...
A6NIY4
Speedy protein E5
DEG_ODPH_VHL_1
86:98
LAPEPEETWVVEM
VHL
0.9466
More...
P0CI01
Speedy protein E6
DEG_ODPH_VHL_1
86:98
LAPEPEETWVVEM
VHL
0.9765
More...
Q495Y8
Speedy protein E2
DEG_ODPH_VHL_1
86:98
LAPEPEETWVVEM
VHL
0.9791
More...
A6NJR5
Putative speedy protein-like protein 3
DEG_ODPH_VHL_1
46:58
LAPEPEETWVVEM
VHL
0.8647
More...