DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 2064:2071

E3 ligase: FBXW7

DEGRON score: 0.5678

ASA_SCORE: 90.75

COIL: 0.8806

CONS_SCORE: 0.5236

DSS_SCORE: 0.5959

HELIX: 0.0149

FCONS_SCORE: 1

RIG_SCORE: 0.7202

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V2069A	TCGA-A5-A0G2	UCEC	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.5825
p.V2069A	DO41235	UCEC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.5825
p.N2062T	TCGA-BR-8589	STAD	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.2778
p.N2062T	DO47813	STAD	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.2778
p.S2078Y	TCGA-E6-A1LX	UCEC	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.1389
p.S2078Y	DO41020	UCEC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1389
p.S2071F	TCGA-J4-A67K	PRAD	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.7982
p.S2071F	DO49828	PRAD	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.7982
p.S2078F	DO223000	BTCA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1389
p.S2078F	DO222843	MELA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1389
p.A2081D	DO229013	COCA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.0556
p.A2081D	DO229016	COCA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.0556
p.A2081D	DO234205	ESAD	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.0556
p.A2081D	DO52365	LUSC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.0556
p.E2060K	DO231207	LUSC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.2222
p.P2068T	DO231209	LUSC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.7031
p.S2071Y	SIDM00025	Head and Neck Carcinoma	GDSC	LSTTPVDS	DEG_SCF_FBW7_1	0.712
p.S2071Y	ACH-002391	Head and Neck Cancer	CCLE	LSTTPVDS	DEG_SCF_FBW7_1	0.712
p.S2071Y	UDSCC2	upper_aerodigestive_tract	COSMIC	LSTTPVDS	DEG_SCF_FBW7_1	0.712
p.N2077S	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	LSTTPVDS	DEG_SCF_FBW7_1	0.1667
p.N2077S	ACH-000809	Esophageal Cancer	CCLE	LSTTPVDS	DEG_SCF_FBW7_1	0.1667
p.N2077S	KYSE-410	oesophagus	COSMIC	LSTTPVDS	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons