DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 649:656

E3 ligase: FBXW7

DEGRON score: 0.877

ASA_SCORE: 93.825

COIL: 0.9216

CONS_SCORE: 0.5236

DSS_SCORE: 0.5676

HELIX: 0.0105

FCONS_SCORE: 0.8522

RIG_SCORE: 0.6822

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P653H	TCGA-AX-A2HC	UCEC	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.7694
p.P653H	TCGA-DU-6392	LGG	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.7694
p.P653H	DO22237	LGG	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.7694
p.P653H	DO41572	UCEC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.7694
p.P653S	TCGA-EE-A2A2	SKCM	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.6752
p.P653S	DO37583	SKCM	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.6752
p.S656T	DO228791	GACA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.6005
p.S656T	DO227496	LAML	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.6005
p.S656T	DO228905	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.6005
p.S656T	DO228926	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.6005
p.S656T	DO228941	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.6005
p.S656T	DO228950	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.6005
p.V654L	TCGA-33-4566	LUSC	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.5654
p.V654L	DO26790	LUSC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.5654
p.D655E	TCGA-90-7769	LUSC	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.5647
p.D655E	DO26822	LUSC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.5647
p.N657S	DO228905	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.3056
p.N657S	DO228926	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.3056
p.N657S	DO228338	MALY	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.3056
p.N657D	DO48701	LIRI	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.3056
p.T658A	TCGA-B5-A3FA	UCEC	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.2778
p.T658A	DO52402	UCEC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.2778
p.T658S	DO228950	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.2778
p.V660L	TCGA-86-7713	LUAD	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.2222
p.V660L	DO229052	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.2222

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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DegronMD: protein-targeted degradation, mutation and drug response to degrons