DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 649:656

E3 ligase: FBXW7

DEGRON score: 0.877

ASA_SCORE: 93.825

COIL: 0.9216

CONS_SCORE: 0.5236

DSS_SCORE: 0.5676

HELIX: 0.0105

FCONS_SCORE: 0.8522

RIG_SCORE: 0.6822

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V654L	TCGA-33-4566	LUSC	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.5654
p.V654L	DO26790	LUSC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.5654
p.T664N	TCGA-85-8288	LUSC	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.1111
p.T664N	DO26963	LUSC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1111
p.V660L	TCGA-86-7713	LUAD	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.2222
p.V660L	DO229052	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.2222
p.V660L	DO24712	LUAD	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.2222
p.D655E	TCGA-90-7769	LUSC	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.5647
p.D655E	DO26822	LUSC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.5647
p.P653H	TCGA-AX-A2HC	UCEC	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.7694
p.P653H	TCGA-DU-6392	LGG	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.7694
p.P653H	DO22237	LGG	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.7694
p.P653H	DO41572	UCEC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.7694
p.T658A	TCGA-B5-A3FA	UCEC	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.2778
p.T658A	DO52402	UCEC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.2778
p.E645Q	TCGA-CV-6936	HNSC	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.2222
p.E645Q	DO14210	HNSC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.2222
p.P653S	TCGA-EE-A2A2	SKCM	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.6752
p.P653S	DO37583	SKCM	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.6752
p.T661I	TCGA-EE-A2MR	SKCM	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.1944
p.T661I	DO37819	SKCM	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1944
p.E645K	TCGA-EE-A3AE	SKCM	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.2222
p.E645K	DO37802	SKCM	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.2222
p.E645K	SIDM00562	Breast Carcinoma	GDSC	LSTTPVDS	DEG_SCF_FBW7_1	0.2222
p.E645K	ACH-002163	Breast Cancer	CCLE	LSTTPVDS	DEG_SCF_FBW7_1	0.2222
p.E645K	MRK-nu-1	breast	COSMIC	LSTTPVDS	DEG_SCF_FBW7_1	0.2222
p.S643N	DO223140	ESCA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1667
p.S656T	DO228791	GACA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.6005
p.S656T	DO227496	LAML	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.6005
p.S656T	DO228905	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.6005
p.S656T	DO228926	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.6005
p.S656T	DO228941	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.6005
p.S656T	DO228950	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.6005
p.N657S	DO228905	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.3056
p.N657S	DO228926	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.3056
p.N657S	DO228338	MALY	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.3056
p.T658S	DO228950	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.2778
p.A642S	DO229019	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1389
p.N657D	DO48701	LIRI	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSTTPVDS

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of LSTTPVDS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	649:656	LSTTPVDS	FBXW7	0.877	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	826:833	LSTTPVDS	FBXW7	0.5625	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	2064:2071	LSTTPVDS	FBXW7	0.5678	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	3066:3073	LSTTPVDS	FBXW7	0.5685	More...