DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 826:833

E3 ligase: FBXW7

DEGRON score: 0.5625

ASA_SCORE: 94.9875

COIL: 0.926

CONS_SCORE: 0.5236

DSS_SCORE: 0.6317

HELIX: 0.013

FCONS_SCORE: 1

RIG_SCORE: 0.6563

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L826H	TCGA-21-1079	LUSC	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.7313
p.L826H	DO26846	LUSC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.7313
p.T825N	TCGA-33-AASB	LUSC	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.3056
p.T825N	DO219125	LUSC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.3056
p.T825N	SIDM00148	Breast Carcinoma	GDSC	LSTTPVDS	DEG_SCF_FBW7_1	0.3056
p.T825N	ACH-000019	Breast Cancer	CCLE	LSTTPVDS	DEG_SCF_FBW7_1	0.3056
p.T825N	ACH-000028	Breast Cancer	CCLE	LSTTPVDS	DEG_SCF_FBW7_1	0.3056
p.T825N	MCF7	breast	COSMIC	LSTTPVDS	DEG_SCF_FBW7_1	0.3056
p.S824G	TCGA-55-8092	LUAD	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.2778
p.S824G	DO26220	LUAD	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.2778
p.S833Y	TCGA-63-A5MW	LUSC	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.712
p.S833Y	DO219169	LUSC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.712
p.S840Y	TCGA-AG-A002	READ	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.1389
p.S840Y	TCGA-BS-A0UV	UCEC	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.1389
p.S840Y	DO42793	UCEC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1389
p.P830S	TCGA-BF-AAP2	SKCM	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.6752
p.P830S	DO225391	BRCA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.6752
p.P830S	DO219466	SKCM	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.6752
p.T838I	DO229016	COCA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1944
p.T838I	DO229348	LAML	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1944
p.T838I	DO228941	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1944
p.T838I	DO228943	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1944
p.T838I	DO228947	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1944
p.T838I	DO228950	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1944
p.T838I	DO224626	LUSC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1944
p.T838I	DO222494	MELA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1944
p.L826I	DO42673	UCEC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.6063
p.D832N	SIDM00995	Other Solid Cancers	GDSC	LSTTPVDS	DEG_SCF_FBW7_1	0.5821
p.D832N	ACH-001328	Skin Cancer	CCLE	LSTTPVDS	DEG_SCF_FBW7_1	0.5821
p.D832N	A431	skin	COSMIC	LSTTPVDS	DEG_SCF_FBW7_1	0.5821
p.P821L	SIDM00150	Colorectal Carcinoma	GDSC	LSTTPVDS	DEG_SCF_FBW7_1	0.1944
p.P821L	ACH-000969	Colon/Colorectal Cancer	CCLE	LSTTPVDS	DEG_SCF_FBW7_1	0.1944
p.P821L	KM12	large_intestine	COSMIC	LSTTPVDS	DEG_SCF_FBW7_1	0.1944
p.P817L	ACH-002256	Leukemia	CCLE	LSTTPVDS	DEG_SCF_FBW7_1	0.0833
p.P817L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LSTTPVDS	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSTTPVDS

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of LSTTPVDS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	649:656	LSTTPVDS	FBXW7	0.877	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	826:833	LSTTPVDS	FBXW7	0.5625	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	2064:2071	LSTTPVDS	FBXW7	0.5678	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	3066:3073	LSTTPVDS	FBXW7	0.5685	More...