DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 3066:3073

E3 ligase: FBXW7

DEGRON score: 0.5685

ASA_SCORE: 93.8625

COIL: 0.9268

CONS_SCORE: 0.5899

DSS_SCORE: 0.5648

HELIX: 0.0135

FCONS_SCORE: 0.9541

RIG_SCORE: 0.6762

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3061L	TCGA-17-Z020	LUAD	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.1944
p.P3061S	TCGA-24-1845	OV	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.1944
p.P3061S	DO29920	OV	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1944
p.S3075C	TCGA-44-2657	LUAD	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.2778
p.S3075C	DO25020	LUAD	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.2778
p.S3080Y	TCGA-AJ-A5DW	UCEC	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.1389
p.S3080Y	DO50075	UCEC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1389
p.S3080C	TCGA-BH-A0HK	BRCA	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.1389
p.S3080C	DO5717	BRCA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1389
p.A3059G	TCGA-E7-A4IJ	BLCA	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.1389
p.A3059G	DO453	BLCA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1389
p.P3076L	TCGA-EE-A2GR	SKCM	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.25
p.P3076L	DO37996	SKCM	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.25
p.D3072Y	TCGA-EE-A3AH	SKCM	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.6214
p.D3072Y	DO222635	MELA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.6214
p.D3072Y	DO37443	SKCM	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.6214
p.P3070H	TCGA-EO-A3B0	UCEC	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.7694
p.P3070H	DO219773	UCEC	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.7694
p.P3057L	TCGA-UY-A9PB	BLCA	TCGA	LSTTPVDS	DEG_SCF_FBW7_1	0.0833
p.P3057L	DO219041	BLCA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.0833
p.E3082K	DO48372	BLCA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.0833
p.S3064R	DO228264	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.2778
p.I3060S	DO229057	LICA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.1667
p.V3077L	DO49185	PACA	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.2222
p.V3083I	DO37659	SKCM	ICGC	LSTTPVDS	DEG_SCF_FBW7_1	0.0556
p.D3072V	MKN7	stomach	COSMIC	LSTTPVDS	DEG_SCF_FBW7_1	0.6674
p.D3072V	KON	upper_aerodigestive_tract	COSMIC	LSTTPVDS	DEG_SCF_FBW7_1	0.6674
p.D3072V	HSC-3	upper_aerodigestive_tract	COSMIC	LSTTPVDS	DEG_SCF_FBW7_1	0.6674
p.D3072V	SNU-C5	large_intestine	COSMIC	LSTTPVDS	DEG_SCF_FBW7_1	0.6674
p.D3072V	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	LSTTPVDS	DEG_SCF_FBW7_1	0.6674

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSTTPVDS

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of LSTTPVDS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	649:656	LSTTPVDS	FBXW7	0.877	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	826:833	LSTTPVDS	FBXW7	0.5625	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	2064:2071	LSTTPVDS	FBXW7	0.5678	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	3066:3073	LSTTPVDS	FBXW7	0.5685	More...