DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 2712:2719

E3 ligase: FBXW7

DEGRON score: 0.8413

ASA_SCORE: 95.3

COIL: 0.9061

CONS_SCORE: 0.5236

DSS_SCORE: 0.5815

HELIX: 0.0118

FCONS_SCORE: 1

RIG_SCORE: 0.6943

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2715A	TCGA-43-A56V	LUSC	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.7139
p.T2715A	DO45535	LUSC	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.7139
p.T2702M	TCGA-76-6286	GBM	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2702M	TCGA-B5-A11X	UCEC	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2702M	DO13552	GBM	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2702M	DO43130	UCEC	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.D2718E	TCGA-B5-A11O	UCEC	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.5647
p.D2718E	DO41650	UCEC	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.5647
p.A2705D	TCGA-NK-A5CR	LUSC	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.1389
p.A2705D	DO219207	LUSC	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.1389
p.P2716A	DO228761	GACA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.7503
p.A2727T	DO228349	MALY	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.1111
p.A2727T	SK-UT-1	soft_tissue	COSMIC	LSTTPVDT	DEG_SCF_FBW7_1	0.1111
p.T2702K	SIDM01126	Small Cell Lung Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2702K	SIDM01147	Gastric Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.L2703V	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0833
p.L2703V	ACH-000945	Lung Cancer	CCLE	LSTTPVDT	DEG_SCF_FBW7_1	0.0833
p.L2703V	NCI-H650	lung	COSMIC	LSTTPVDT	DEG_SCF_FBW7_1	0.0833
p.P2716S	SIDM00920	Breast Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons