DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 531:538

E3 ligase: FBXW7

DEGRON score: 0.9431

ASA_SCORE: 92.625

COIL: 0.8624

CONS_SCORE: 0.6534

DSS_SCORE: 0.621

HELIX: 0.0131

FCONS_SCORE: 1.032

RIG_SCORE: 0.6613

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T534I	TCGA-AJ-A3EL	UCEC	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.7078
p.T534I	DO41542	UCEC	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.7078
p.P535T	TCGA-AP-A059	UCEC	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.7031
p.P535T	DO41361	UCEC	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.7031
p.T533I	ACH-001853	Bile Duct Cancer	CCLE	LSTTPVDT	DEG_SCF_FBW7_1	0.5966
p.V536F	TCGA-55-8614	LUAD	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.5957
p.V536F	DO48885	LUAD	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.5957
p.S532P	TCGA-UF-A7J9	HNSC	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.5641
p.S532P	DO52111	HNSC	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.5641
p.T530A	TCGA-E7-A541	BLCA	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.3056
p.T530A	DO44037	BLCA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.3056
p.S526F	DO220877	MELA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.1944
p.A524T	TCGA-BR-7851	STAD	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.1389
p.A524T	DO38711	STAD	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.1389
p.S546T	DO228960	LICA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.1111
p.S546T	DO229055	LICA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.1111
p.P522L	TCGA-B5-A3FC	UCEC	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.0833
p.P522L	DO229058	LICA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.0833
p.P522L	DO41871	UCEC	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.0833
p.E547K	TCGA-QQ-A5VD	SARC	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.0833
p.E547K	DO222662	MELA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.0833
p.E547K	DO220252	SARC	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.0833
p.M521T	DO229051	LICA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.M521I	SIDM00670	Pancreatic Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.M521I	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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DegronMD: protein-targeted degradation, mutation and drug response to degrons