DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 2830:2837

E3 ligase: FBXW7

DEGRON score: 0.5635

ASA_SCORE: 94.8125

COIL: 0.9159

CONS_SCORE: 0.5236

DSS_SCORE: 0.6198

HELIX: 0.0114

FCONS_SCORE: 1

RIG_SCORE: 0.6759

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2834H	TCGA-AP-A1DV	UCEC	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.7694
p.P2834H	DO43186	UCEC	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.7694
p.P2834L	TCGA-EE-A3AE	SKCM	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.7582
p.P2834L	DO37802	SKCM	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.7582
p.S2831L	TCGA-B5-A11R	UCEC	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.6556
p.S2831L	DO43787	UCEC	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.6556
p.G2828S	DO227496	LAML	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2778
p.G2828S	DO228946	LICA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2778
p.G2828S	DO228960	LICA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2778
p.G2828S	DO229029	LICA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2778
p.G2828S	DO229051	LICA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2778
p.G2828S	DO229053	LICA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2778
p.G2828S	DO229056	LICA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2778
p.G2828S	DO45251	LIRI	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2778
p.G2828S	DO232656	PBCA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2778
p.E2826K	TCGA-GF-A6C9	SKCM	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.2222
p.E2826K	DO51254	SKCM	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2222
p.S2825Y	TCGA-GN-A266	SKCM	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.1944
p.S2825Y	DO37432	SKCM	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.1944
p.S2824T	SIDM00186	Kidney Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.1667
p.S2824T	SIDM01651	Non-Cancerous	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.1667
p.S2824T	ACH-002353	Non-Cancerous	CCLE	LSTTPVDT	DEG_SCF_FBW7_1	0.1667
p.S2824R	SIDM00410	Other Blood Cancers	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.1667
p.S2824R	ACH-002317	Leukemia	CCLE	LSTTPVDT	DEG_SCF_FBW7_1	0.1667
p.S2824R	YT	haematopoietic_and_lymphoid_tissue	COSMIC	LSTTPVDT	DEG_SCF_FBW7_1	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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DegronMD: protein-targeted degradation, mutation and drug response to degrons