DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 2830:2837

E3 ligase: FBXW7

DEGRON score: 0.5635

ASA_SCORE: 94.8125

COIL: 0.9159

CONS_SCORE: 0.5236

DSS_SCORE: 0.6198

HELIX: 0.0114

FCONS_SCORE: 1

RIG_SCORE: 0.6759

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2823V	TCGA-A5-A2K7	UCEC	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.1389
p.A2823V	DO41271	UCEC	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.1389
p.P2834H	TCGA-AP-A1DV	UCEC	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.7694
p.P2834H	DO43186	UCEC	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.7694
p.S2831L	TCGA-B5-A11R	UCEC	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.6556
p.S2831L	DO43787	UCEC	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.6556
p.A2847V	TCGA-CV-7568	HNSC	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.A2847V	DO14160	HNSC	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.P2834L	TCGA-EE-A3AE	SKCM	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.7582
p.P2834L	DO37802	SKCM	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.7582
p.V2822M	TCGA-FI-A2D5	UCEC	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.1111
p.V2822M	DO41331	UCEC	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.1111
p.E2826K	TCGA-GF-A6C9	SKCM	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.2222
p.E2826K	DO51254	SKCM	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2222
p.S2825Y	TCGA-GN-A266	SKCM	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.1944
p.S2825Y	DO37432	SKCM	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.1944
p.P2821S	DO8264	COAD	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.0833
p.G2828S	DO227496	LAML	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2778
p.G2828S	DO228946	LICA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2778
p.G2828S	DO228960	LICA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2778
p.G2828S	DO229029	LICA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2778
p.G2828S	DO229051	LICA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2778
p.G2828S	DO229053	LICA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2778
p.G2828S	DO229056	LICA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2778
p.G2828S	DO45251	LIRI	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2778
p.G2828S	DO232656	PBCA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2778
p.A2847S	DO229018	LICA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	DO27833	MALY	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM00773	Non-Cancerous	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM00967	Ovarian Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM00454	Rhabdomyosarcoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM00656	Burkitt's Lymphoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM00690	Head and Neck Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM01112	Osteosarcoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM00529	Breast Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM00844	Burkitt's Lymphoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM01133	Other Solid Cancers	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM00863	Burkitt's Lymphoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM00721	Small Cell Lung Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM00118	Colorectal Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM00774	Breast Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM00257	Neuroblastoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM00673	Breast Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM00641	Burkitt's Lymphoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM01664	Prostate Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.T2820M	SIDM01752	Pancreatic Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.S2824T	SIDM00186	Kidney Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.1667
p.S2824T	SIDM01651	Non-Cancerous	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.1667
p.S2824T	ACH-002353	Non-Cancerous	CCLE	LSTTPVDT	DEG_SCF_FBW7_1	0.1667
p.S2824R	SIDM00410	Other Blood Cancers	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.1667
p.S2824R	ACH-002317	Leukemia	CCLE	LSTTPVDT	DEG_SCF_FBW7_1	0.1667
p.S2824R	YT	haematopoietic_and_lymphoid_tissue	COSMIC	LSTTPVDT	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSTTPVDT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of LSTTPVDT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	531:538	LSTTPVDT	FBXW7	0.9431	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	708:715	LSTTPVDT	FBXW7	0.5952	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	2712:2719	LSTTPVDT	FBXW7	0.8413	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	2830:2837	LSTTPVDT	FBXW7	0.5635	More...