DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 708:715

E3 ligase: FBXW7

DEGRON score: 0.5952

ASA_SCORE: 95.65

COIL: 0.9288

CONS_SCORE: 0.5236

DSS_SCORE: 0.5948

HELIX: 0.0118

FCONS_SCORE: 1

RIG_SCORE: 0.6835

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E704G	TCGA-A4-A57E	KIRP	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.2222
p.E704G	DO44517	KIRP	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2222
p.A725V	TCGA-A5-A0G2	UCEC	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.A725V	DO41235	UCEC	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.0556
p.P718L	TCGA-AN-A0AM	BRCA	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.25
p.P718L	DO4191	BRCA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.25
p.T715I	TCGA-BR-4184	STAD	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.7078
p.T715I	DO38328	STAD	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.7078
p.S703Y	TCGA-EO-A3B0	UCEC	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.1944
p.S703Y	DO219773	UCEC	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.1944
p.V719M	TCGA-HU-A4G8	STAD	TCGA	LSTTPVDT	DEG_SCF_FBW7_1	0.2222
p.V719M	DO47819	STAD	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.2222
p.P712S	DO217844	BRCA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.6752
p.P712S	DO220893	MELA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.6752
p.S702I	DO233857	GACA	ICGC	LSTTPVDT	DEG_SCF_FBW7_1	0.1667
p.T723N	SIDM01520	Oral Cavity Carcinoma	GDSC	LSTTPVDT	DEG_SCF_FBW7_1	0.1111
p.S709L	ACH-001973	Metastasis	CCLE	LSTTPVDT	DEG_SCF_FBW7_1	0.6556

DegronMD: protein-targeted degradation, mutation and drug response to degrons