DegronMD

Uniprot ID: Q8TAX7

Source protein: Mucin-7

Source gene: MUC7

Class: DEG_SCF_FBW7_1

Location: 169:175

E3 ligase: FBXW7

DEGRON score: 0.9903

ASA_SCORE: 90.7429

COIL: 0.9684

CONS_SCORE: 0.9643

DSS_SCORE: 0.7866

HELIX: 0.0117

FCONS_SCORE: 1.0794

RIG_SCORE: 0.5295

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T171I	TCGA-17-Z062	LUAD	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.7078
p.T171I	TCGA-D3-A8GL	SKCM	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.7078
p.T171I	DO50287	SKCM	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.7078
p.T165A	TCGA-64-5781	LUAD	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.2222
p.T165A	DO23740	LUAD	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.2222
p.P170H	TCGA-92-7340	LUSC	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.6583
p.P170H	DO26775	LUSC	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.6583
p.T175A	TCGA-CG-5721	STAD	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.7139
p.T175A	DO38192	STAD	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.7139
p.T175S	TCGA-FX-A3RE	SARC	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.6005
p.T175S	DO220122	SARC	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.6005
p.P177Q	DO222874	COCA	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.2778
p.P177Q	DO229051	LICA	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.2778
p.P177Q	DO229053	LICA	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.2778
p.P177Q	DO22804	LICA	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.2778
p.P177Q	DO230545	LUSC	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.2778
p.S173P	DO228905	LICA	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.5641
p.S173P	DO230535	LUSC	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.5641
p.S173P	DO231040	LUSC	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.5641
p.P160S	DO228944	LICA	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.0833
p.P169T	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PPTPSAT	DEG_SCF_FBW7_1	0.7031
p.P169T	SIDM00032	Bladder Carcinoma	GDSC	PPTPSAT	DEG_SCF_FBW7_1	0.7031
p.P169T	SIDM01147	Gastric Carcinoma	GDSC	PPTPSAT	DEG_SCF_FBW7_1	0.7031
p.T176S	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PPTPSAT	DEG_SCF_FBW7_1	0.3056
p.T176S	SIDM00032	Bladder Carcinoma	GDSC	PPTPSAT	DEG_SCF_FBW7_1	0.3056
p.T176S	SIDM01147	Gastric Carcinoma	GDSC	PPTPSAT	DEG_SCF_FBW7_1	0.3056
p.T166A	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	PPTPSAT	DEG_SCF_FBW7_1	0.25
p.T166A	ACH-002337	Lung Cancer	CCLE	PPTPSAT	DEG_SCF_FBW7_1	0.25
p.A178S	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	PPTPSAT	DEG_SCF_FBW7_1	0.25
p.A178S	ACH-000869	Lung Cancer	CCLE	PPTPSAT	DEG_SCF_FBW7_1	0.25
p.A178S	NCI-H1568	lung	COSMIC	PPTPSAT	DEG_SCF_FBW7_1	0.25
p.P169Q	ACH-001172	Brain Cancer	CCLE	PPTPSAT	DEG_SCF_FBW7_1	0.7035

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTPSAT

Degron related mutations and impact score

Drug responses associated with MUC7 mutations

All proteins holding degron of PPTPSAT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	169:175	PPTPSAT	FBXW7	0.9903	More...
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	192:198	PPTPSAT	FBXW7	0.8107	More...
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	238:244	PPTPSAT	FBXW7	0.7808	More...
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	284:290	PPTPSAT	FBXW7	0.9447	More...