DegronMD

Uniprot ID: Q8TAX7

Source protein: Mucin-7

Source gene: MUC7

Class: DEG_SCF_FBW7_1

Location: 284:290

E3 ligase: FBXW7

DEGRON score: 0.9447

ASA_SCORE: 93.0286

COIL: 0.9721

CONS_SCORE: 0.8881

DSS_SCORE: 0.8164

HELIX: 0.0123

FCONS_SCORE: 1.0328

RIG_SCORE: 0.5105

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A274T	TCGA-29-1702	OV	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.0556
p.A274T	DO11441	GBM	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.0556
p.A274T	DO29528	OV	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.0556
p.A274T	DO33084	PACA	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.0556
p.A274T	SIDM02057	Colorectal Carcinoma	GDSC	PPTPSAT	DEG_SCF_FBW7_1	0.0556
p.P292S	TCGA-33-A5GW	LUSC	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.2778
p.P292S	TCGA-AX-A2HD	UCEC	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.2778
p.P292S	DO219122	LUSC	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.2778
p.P292S	DO42608	UCEC	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.2778
p.A283P	TCGA-53-7626	LUAD	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.3056
p.A283P	DO23774	LUAD	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.3056
p.S297Y	TCGA-61-2104	OV	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.1389
p.S297Y	DO31849	OV	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.1389
p.A293V	TCGA-69-7979	LUAD	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.25
p.A293V	TCGA-A5-A1OF	UCEC	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.25
p.A293V	DO23874	LUAD	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.25
p.A293V	DO42568	UCEC	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.25
p.S288F	TCGA-DK-A3IU	BLCA	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.6871
p.S288F	DO612	BLCA	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.6871
p.P285H	TCGA-E2-A1L7	BRCA	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.6583
p.P285H	DO1937	BRCA	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.6583
p.S297F	TCGA-EE-A2GO	SKCM	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.1389
p.S297F	TCGA-EE-A2MR	SKCM	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.1389
p.S297F	DO37819	SKCM	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.1389
p.S297F	DO37823	SKCM	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.1389
p.P277L	TCGA-FS-A4FC	SKCM	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.1389
p.P277L	DO23158	LINC	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.1389
p.P277L	DO37762	SKCM	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.1389
p.P298S	DO225336	BRCA	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.1111
p.E279D	DO227501	LAML	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.1944
p.T291I	DO230993	LUSC	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.3056
p.T291I	DO230990	LUSC	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.3056
p.T281R	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPTPSAT	DEG_SCF_FBW7_1	0.25
p.T281R	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPSAT	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTPSAT

Degron related mutations and impact score

Drug responses associated with MUC7 mutations

All proteins holding degron of PPTPSAT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	169:175	PPTPSAT	FBXW7	0.9903	More...
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	192:198	PPTPSAT	FBXW7	0.8107	More...
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	238:244	PPTPSAT	FBXW7	0.7808	More...
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	284:290	PPTPSAT	FBXW7	0.9447	More...