DegronMD

Uniprot ID: Q8TAX7

Source protein: Mucin-7

Source gene: MUC7

Class: DEG_SCF_FBW7_1

Location: 238:244

E3 ligase: FBXW7

DEGRON score: 0.7808

ASA_SCORE: 91.2

COIL: 0.9651

CONS_SCORE: 0.4139

DSS_SCORE: 0.7667

HELIX: 0.0133

FCONS_SCORE: 0.7312

RIG_SCORE: 0.5213

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P232Q	TCGA-91-6828	LUAD	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.1667
p.P232Q	DO26150	LUAD	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.1667
p.P254Q	TCGA-A8-A07J	BRCA	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.0556
p.A236V	TCGA-B9-A69E	KIRP	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.2778
p.A236V	DO44513	KIRP	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.2778
p.E233K	TCGA-DA-A1IC	SKCM	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.1944
p.E233K	DO37430	SKCM	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.1944
p.A230T	TCGA-EB-A4XL	SKCM	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.1111
p.A230T	DO47401	SKCM	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.1111
p.A253T	TCGA-HQ-A5ND	BLCA	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.0833
p.A253T	DO51899	BLCA	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.0833
p.T245S	TCGA-VS-A8QC	CESC	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.3056
p.T245S	DO51628	CESC	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.3056
p.A237V	DO229346	LAML	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.3056
p.A237V	DO50995	LAML	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.3056
p.A237V	DO225404	LAML	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.3056
p.A237V	DO228941	LICA	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.3056
p.A237V	DO229012	LICA	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.3056
p.A237V	DO52365	LUSC	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.3056
p.A237V	DO52366	LUSC	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.3056
p.S242P	DO229346	LAML	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.5641
p.S242P	DO225404	LAML	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.5641
p.S242P	DO51020	LAML	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.5641
p.S242P	DO228941	LICA	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.5641
p.S242P	DO229024	LICA	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.5641
p.S242P	DO52364	LUSC	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.5641
p.S242P	DO52365	LUSC	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.5641
p.P254S	DO222550	MELA	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.0556
p.A237D	SIDM02064	Colorectal Carcinoma	GDSC	PPTPSAT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	169:175	PPTPSAT	FBXW7	0.9903	More...
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	192:198	PPTPSAT	FBXW7	0.8107	More...
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	238:244	PPTPSAT	FBXW7	0.7808	More...
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	284:290	PPTPSAT	FBXW7	0.9447	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTPSAT

Degron related mutations and impact score

Drug responses associated with MUC7 mutations

All proteins holding degron of PPTPSAT