DegronMD

Uniprot ID: Q8TAX7

Source protein: Mucin-7

Source gene: MUC7

Class: DEG_SCF_FBW7_1

Location: 192:198

E3 ligase: FBXW7

DEGRON score: 0.8107

ASA_SCORE: 89.3

COIL: 0.9733

CONS_SCORE: 0.893

DSS_SCORE: 0.8313

HELIX: 0.0114

FCONS_SCORE: 0.9921

RIG_SCORE: 0.5076

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E187Q	TCGA-49-6742	LUAD	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.1944
p.E187Q	DO25622	LUAD	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.1944
p.T189S	TCGA-55-5899	LUAD	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.25
p.T189S	DO26042	LUAD	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.25
p.T188A	TCGA-A5-A1OF	UCEC	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.2222
p.T188A	DO42568	UCEC	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.2222
p.P192S	TCGA-AB-2808	LAML	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.6752
p.P192S	DO21487	LAML	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.6752
p.E187K	TCGA-BH-A1F8	BRCA	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.1944
p.E187K	DO1512	BRCA	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.1944
p.A191S	TCGA-CC-A123	LIHC	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.3056
p.A191S	DO23038	LIHC	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.3056
p.A190T	TCGA-EA-A410	CESC	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.2778
p.A190T	DO49929	CESC	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.2778
p.P195L	TCGA-EE-A181	SKCM	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.7582
p.P195L	TCGA-EE-A2GJ	SKCM	TCGA	PPTPSAT	DEG_SCF_FBW7_1	0.7582
p.P195L	DO37746	SKCM	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.7582
p.P195L	DO37444	SKCM	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.7582
p.P186Q	DO227504	LAML	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.1667
p.P186Q	ACH-002693	Sarcoma	CCLE	PPTPSAT	DEG_SCF_FBW7_1	0.1667
p.A191V	DO230937	LUSC	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.3056
p.A207V	DO222521	MELA	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.0833
p.P195S	DO222875	MELA	ICGC	PPTPSAT	DEG_SCF_FBW7_1	0.6752
p.A197T	SIDM00620	Glioblastoma	GDSC	PPTPSAT	DEG_SCF_FBW7_1	0.6028
p.A197T	SIDM00953	Small Cell Lung Carcinoma	GDSC	PPTPSAT	DEG_SCF_FBW7_1	0.6028
p.A197T	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	PPTPSAT	DEG_SCF_FBW7_1	0.6028
p.A197T	SIDM01721	Non-Cancerous	GDSC	PPTPSAT	DEG_SCF_FBW7_1	0.6028
p.A197T	SIDM00191	Kidney Carcinoma	GDSC	PPTPSAT	DEG_SCF_FBW7_1	0.6028
p.A197T	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPTPSAT	DEG_SCF_FBW7_1	0.6028
p.Q200E	SIDM01009	Neuroblastoma	GDSC	PPTPSAT	DEG_SCF_FBW7_1	0.2778
p.Q200E	ACH-000259	Neuroblastoma	CCLE	PPTPSAT	DEG_SCF_FBW7_1	0.2778
p.Q200E	KELLY	autonomic_ganglia	COSMIC	PPTPSAT	DEG_SCF_FBW7_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTPSAT

Degron related mutations and impact score

Drug responses associated with MUC7 mutations

All proteins holding degron of PPTPSAT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	169:175	PPTPSAT	FBXW7	0.9903	More...
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	192:198	PPTPSAT	FBXW7	0.8107	More...
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	238:244	PPTPSAT	FBXW7	0.7808	More...
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	284:290	PPTPSAT	FBXW7	0.9447	More...