DegronMD

Uniprot ID: A6NNL0

Source protein: NUT family member 2B

Source gene: NUTM2B

Class: DEG_SCF_FBW7_1

Location: 182:188

E3 ligase: FBXW7

DEGRON score: 0.963

ASA_SCORE: 52.8714

COIL: 0.7493

CONS_SCORE: 0.4619

DSS_SCORE: 0.4981

HELIX: 0.0471

FCONS_SCORE: 1.0251

RIG_SCORE: 0.7475

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G197R	DO50879	LICA	ICGC	PSTPLVT	DEG_SCF_FBW7_1	0.0833
p.F181L	DO218857	SKCA	ICGC	PSTPLVT	DEG_SCF_FBW7_1	0.3056
p.G192D	ACH-000939	Sarcoma	CCLE	PSTPLVT	DEG_SCF_FBW7_1	0.2222
p.S183R	MFE-319	endometrium	COSMIC	PSTPLVT	DEG_SCF_FBW7_1	0.6316
p.S183C	MFE-319	endometrium	COSMIC	PSTPLVT	DEG_SCF_FBW7_1	0.643
p.T188I	MFE-319	endometrium	COSMIC	PSTPLVT	DEG_SCF_FBW7_1	0.7078

DegronMD: protein-targeted degradation, mutation and drug response to degrons