DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PSTPLVT
Uniprot ID:
B1AL46
Source protein:
NUT family member 2E
Source gene:
NUTM2E
Class:
DEG_SCF_FBW7_1
Location:
182:188
E3 ligase:
FBXW7
DEGRON score:
0.9833
ASA_SCORE:
56.8
COIL:
0.8023
CONS_SCORE:
0.4625
DSS_SCORE:
0.4936
HELIX:
0.0386
FCONS_SCORE:
1.043
RIG_SCORE:
0.7424
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with NUTM2E mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PSTPLVT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NNL0
NUT family member 2B
DEG_SCF_FBW7_1
182:188
PSTPLVT
FBXW7
0.963
More...
B1AL46
NUT family member 2E
DEG_SCF_FBW7_1
182:188
PSTPLVT
FBXW7
0.9833
More...
Q5VT03
NUT family member 2D
DEG_SCF_FBW7_1
110:116
PSTPLVT
FBXW7
0.9598
More...