DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PSTPLVT
Uniprot ID:
Q5VT03
Source protein:
NUT family member 2D
Source gene:
NUTM2D
Class:
DEG_SCF_FBW7_1
Location:
110:116
E3 ligase:
FBXW7
DEGRON score:
0.9598
ASA_SCORE:
46.8
COIL:
0.7359
CONS_SCORE:
0.3354
DSS_SCORE:
0.4929
HELIX:
0.0647
FCONS_SCORE:
1.0248
RIG_SCORE:
0.737
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G102C
TCGA-09-2044
OV
TCGA
PSTPLVT
DEG_SCF_FBW7_1
0.1111
p.G102C
DO28923
OV
ICGC
PSTPLVT
DEG_SCF_FBW7_1
0.1111
Drug responses associated with NUTM2D mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PSTPLVT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NNL0
NUT family member 2B
DEG_SCF_FBW7_1
182:188
PSTPLVT
FBXW7
0.963
More...
B1AL46
NUT family member 2E
DEG_SCF_FBW7_1
182:188
PSTPLVT
FBXW7
0.9833
More...
Q5VT03
NUT family member 2D
DEG_SCF_FBW7_1
110:116
PSTPLVT
FBXW7
0.9598
More...