DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PSTPLVT
Uniprot ID:
Q5VT03
Source protein:
NUT family member 2D
Source gene:
NUTM2D
Class:
DEG_SCF_FBW7_1
Location:
110:116
E3 ligase:
FBXW7
DEGRON score:
0.9598
ASA_SCORE:
46.8
COIL:
0.7359
CONS_SCORE:
0.3354
DSS_SCORE:
0.4929
HELIX:
0.0647
FCONS_SCORE:
1.0248
RIG_SCORE:
0.737
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G102C
TCGA-09-2044
OV
TCGA
PSTPLVT
DEG_SCF_FBW7_1
0.1111
p.G102C
DO28923
OV
ICGC
PSTPLVT
DEG_SCF_FBW7_1
0.1111
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Drug responses associated with NUTM2D mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of PSTPLVT
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NNL0
NUT family member 2B
DEG_SCF_FBW7_1
182:188
PSTPLVT
FBXW7
0.963
More...
Q5VT03
NUT family member 2D
DEG_SCF_FBW7_1
110:116
PSTPLVT
FBXW7
0.9598
More...
B1AL46
NUT family member 2E
DEG_SCF_FBW7_1
182:188
PSTPLVT
FBXW7
0.9833
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