DegronMD

Uniprot ID: P62263

Source protein: 40S ribosomal protein S14

Source gene: RPS14

Class: DEG_SCF_FBW7_1

Location: 132:137

E3 ligase: FBXW7

DEGRON score: 0.9991

ASA_SCORE: 49.8833

COIL: 0.833

CONS_SCORE: 0.8606

DSS_SCORE: 0.6471

HELIX: 0.011

FCONS_SCORE: 1.1756

RIG_SCORE: 0.7077

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P136S	TCGA-FR-A726	SKCM	TCGA	VTPIPS	DEG_SCF_FBW7_1	0.5641
p.P136S	DO48665	SKCM	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.5641
p.P136S	SIDM00545	Melanoma	GDSC	VTPIPS	DEG_SCF_FBW7_1	0.5641
p.P136S	ACH-000987	Skin Cancer	CCLE	VTPIPS	DEG_SCF_FBW7_1	0.5641
p.P136S	Mewo	skin	COSMIC	VTPIPS	DEG_SCF_FBW7_1	0.5641
p.R128W	TCGA-VS-A9UJ	CESC	TCGA	VTPIPS	DEG_SCF_FBW7_1	0.2222
p.R128W	DO219735	CESC	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.2222
p.R128W	DO230323	COCA	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.2222
p.V132D	DO27831	MALY	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.7785
p.R141H	DO49138	PACA	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.2222
p.R147C	SIDM00777	Colorectal Carcinoma	GDSC	VTPIPS	DEG_SCF_FBW7_1	0.0556
p.R147C	ACH-000360	Colon/Colorectal Cancer	CCLE	VTPIPS	DEG_SCF_FBW7_1	0.0556
p.R147C	NCI-H508	large_intestine	COSMIC	VTPIPS	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons