DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 1980:1985

E3 ligase: FBXW7

DEGRON score: 0.7694

ASA_SCORE: 90.6667

COIL: 0.9167

CONS_SCORE: 0.2049

DSS_SCORE: 0.5687

HELIX: 0.0148

FCONS_SCORE: 0.9725

RIG_SCORE: 0.712

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1987F	TCGA-55-6983	LUAD	TCGA	VTPIPS	DEG_SCF_FBW7_1	0.2778
p.S1970G	TCGA-85-8580	LUSC	TCGA	VTPIPS	DEG_SCF_FBW7_1	0.0556
p.T1974K	TCGA-AJ-A3OK	UCEC	TCGA	VTPIPS	DEG_SCF_FBW7_1	0.1667
p.T1974K	TCGA-L7-A6VZ	ESCA	TCGA	VTPIPS	DEG_SCF_FBW7_1	0.1667
p.P1975S	TCGA-AJ-A3OK	UCEC	TCGA	VTPIPS	DEG_SCF_FBW7_1	0.1944
p.V1980I	TCGA-BJ-A0ZB	THCA	TCGA	VTPIPS	DEG_SCF_FBW7_1	0.5965
p.S1990F	DO23643	LUAD	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.1944
p.S1973G	DO45549	LUSC	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.1389
p.V1983I	DO39363	THCA	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.7076
p.P1978S	DO43602	UCEC	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.2778
p.T1977K	DO43602	UCEC	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.25
p.T1991A	SIDM00136	Colorectal Carcinoma	GDSC	VTPIPS	DEG_SCF_FBW7_1	0.1667
p.T1991A	SIDM00793	Burkitt's Lymphoma	GDSC	VTPIPS	DEG_SCF_FBW7_1	0.1667
p.A1977V	SIDM01045	Endometrial Carcinoma	GDSC	VTPIPS	DEG_SCF_FBW7_1	0.25
p.A1977V	ACH-000978	Endometrial/Uterine Cancer	CCLE	VTPIPS	DEG_SCF_FBW7_1	0.25
p.A1977V	EN	endometrium	COSMIC	VTPIPS	DEG_SCF_FBW7_1	0.25
p.R1994H	SIDM00793	Burkitt's Lymphoma	GDSC	VTPIPS	DEG_SCF_FBW7_1	0.0833
p.L1988P	SIDM01133	Other Solid Cancers	GDSC	VTPIPS	DEG_SCF_FBW7_1	0.25
p.T1981A	SIDM01619	Endometrial Carcinoma	GDSC	VTPIPS	DEG_SCF_FBW7_1	0.7139
p.S1986P	ACH-000105	Leukemia	CCLE	VTPIPS	DEG_SCF_FBW7_1	0.3056
p.S1986P	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	VTPIPS	DEG_SCF_FBW7_1	0.3056
p.P1982A	CHSA0108	bone	COSMIC	VTPIPS	DEG_SCF_FBW7_1	0.7503
p.P1982A	OE19	oesophagus	COSMIC	VTPIPS	DEG_SCF_FBW7_1	0.7503

DegronMD: protein-targeted degradation, mutation and drug response to degrons