DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 4323:4328

E3 ligase: FBXW7

DEGRON score: 0.992

ASA_SCORE: 96.05

COIL: 0.9473

CONS_SCORE: 0.2715

DSS_SCORE: 0.554

HELIX: 0.0113

FCONS_SCORE: 0.8743

RIG_SCORE: 0.7132

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T4321N	TCGA-44-2668	LUAD	TCGA	VTPIPS	DEG_SCF_FBW7_1	0.2778
p.L4331H	TCGA-49-AARQ	LUAD	TCGA	VTPIPS	DEG_SCF_FBW7_1	0.25
p.S4318Y	TCGA-91-6848	LUAD	TCGA	VTPIPS	DEG_SCF_FBW7_1	0.6389
p.S4318F	TCGA-EE-A29E	SKCM	TCGA	VTPIPS	DEG_SCF_FBW7_1	0.6389
p.A4315T	TCGA-EE-A3JD	SKCM	TCGA	VTPIPS	DEG_SCF_FBW7_1	0.1111
p.P4325A	TCGA-F1-6177	STAD	TCGA	VTPIPS	DEG_SCF_FBW7_1	0.7503
p.P4338S	TCGA-FR-A7U9	SKCM	TCGA	VTPIPS	DEG_SCF_FBW7_1	0.0556
p.V4326F	DO48371	BLCA	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.7068
p.V4326F	DO229221	THCA	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.7068
p.S4316I	DO52707	CLLE	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.5833
p.A4323V	DO234153	ESAD	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.6936
p.T4324N	DO25232	LUAD	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.7055
p.S4321Y	DO23846	LUAD	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.2778
p.L4334H	DO51189	LUAD	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.1667
p.S4316G	DO30310	OV	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.5833
p.S4321F	DO37831	SKCM	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.2778
p.A4318T	DO50299	SKCM	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.6389
p.P4328A	DO38727	STAD	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.7503
p.T4315A	DO41109	UCEC	ICGC	VTPIPS	DEG_SCF_FBW7_1	0.1111
p.P4325T	SIDM02015	Colorectal Carcinoma	GDSC	VTPIPS	DEG_SCF_FBW7_1	0.7031
p.S4322N	SIDM00607	Glioblastoma	GDSC	VTPIPS	DEG_SCF_FBW7_1	0.3056
p.S4322N	KNS-42	central_nervous_system	COSMIC	VTPIPS	DEG_SCF_FBW7_1	0.3056
p.S4329C	ACH-000839	Bladder Cancer	CCLE	VTPIPS	DEG_SCF_FBW7_1	0.3056
p.K4317T	U-118-MG	central_nervous_system	COSMIC	VTPIPS	DEG_SCF_FBW7_1	0.2778
p.K4317T	HCC202	breast	COSMIC	VTPIPS	DEG_SCF_FBW7_1	0.2778
p.K4317T	TOV-21G	ovary	COSMIC	VTPIPS	DEG_SCF_FBW7_1	0.2778
p.K4317T	BICR78	upper_aerodigestive_tract	COSMIC	VTPIPS	DEG_SCF_FBW7_1	0.2778
p.K4317T	HCT-15	large_intestine	COSMIC	VTPIPS	DEG_SCF_FBW7_1	0.2778
p.K4317T	GCT	soft_tissue	COSMIC	VTPIPS	DEG_SCF_FBW7_1	0.2778
p.S4318P	HCC202	breast	COSMIC	VTPIPS	DEG_SCF_FBW7_1	0.6389
p.S4318P	TOV-21G	ovary	COSMIC	VTPIPS	DEG_SCF_FBW7_1	0.6389
p.S4318P	M14	skin	COSMIC	VTPIPS	DEG_SCF_FBW7_1	0.6389
p.S4318P	U-118-MG	central_nervous_system	COSMIC	VTPIPS	DEG_SCF_FBW7_1	0.6389
p.S4318P	BICR78	upper_aerodigestive_tract	COSMIC	VTPIPS	DEG_SCF_FBW7_1	0.6389
p.S4318P	HCT-15	large_intestine	COSMIC	VTPIPS	DEG_SCF_FBW7_1	0.6389
p.S4318P	RPMI-2650	upper_aerodigestive_tract	COSMIC	VTPIPS	DEG_SCF_FBW7_1	0.6389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTPIPS

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of VTPIPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P62263	40S ribosomal protein S14	DEG_SCF_FBW7_1	132:137	VTPIPS	FBXW7	0.9991	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	1980:1985	VTPIPS	FBXW7	0.7694	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4323:4328	VTPIPS	FBXW7	0.992	More...